Association of CYP11B2 gene polymorphism with ischemic stroke in the north Chinese Han population

Yan, Guanhua; Wang, Yan

doi:10.4103/0028-3886.103196

Cited by 11 publications

(10 citation statements)

References 25 publications

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“…The publication of Tu et al [14] presented two separate case-control studies, each study in one publication was considered separately for pooling analysis. Therefore, eleven publications including 12 studies were involved in this meta-analysis, involving 3,620 ischemic stroke cases and 4,090 controls [1], [2], [6], [9], [12], [13], [14], [15], [16], [17], [18]. The main characteristics of the studies were summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Aldosterone, one of the main effectors of the RAAS, affects sodium balance, intravascular volume, and blood pressure [2], [3]. Aldosterone synthase (CYP11B2) is a key enzyme in the biosynthesis of aldosterone, the CYP11B2 gene located in 8q22 spans approximately 7 kb and contains 9 exons and 8 introns [4], [5].…”

Section: Introductionmentioning

confidence: 99%

“…The C-344T polymorphism has been reported to associate with higher aldosterone synthase activity and enhanced aldosterone production [7], which in turn induces sodium and water retention, resulting in increased peripheral vascular resistance, and precipitation of adverse vascular remodeling, vasoconstriction, thrombosis, and vessel wall damage, and ultimately affects the odds of stroke development [9], [10], [11]. As for ischemic stroke, a variety of epidemiological studies have evaluated the role of CYP11B2 C-344T polymorphism, however, there were apparent discrepancies among the results of these association studies [1], [2],[6],[9],[12],[13],[14],[15],[16],[17],[18]. It is likely that CYP11B2 C-344T polymorphism may influence the susceptibility of ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

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Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects

Zhang

Chang

et al. 2013

PLoS ONE

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BackgroundThe association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed.MethodsBased on comprehensive searches of Medline, Embase, Web of Science, CNKI and CBM databases, we identified and abstracted outcome data from all articles to evaluate the association between CYP11B2 polymorphism and ischemic stroke. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed in all genetic models. Fixed or random effects model was separately used depending on the heterogeneity between studies. Publication bias was tested by Begg's funnel plot and Egger's regression test.ResultsA total of 12 studies including 3,620 ischemic stroke cases and 4,090 controls were identified. There was no statistical evidence of association between CYP11B2 C-344T polymorphism and ischemic stroke in all genetic models (allelic model: OR = 1.19, 95% CI = 0.95–1.49; additive model: OR = 1.43, 95% CI = 0.91–2.27; dominant model: OR = 1.30, 95% CI = 0.89–1.89; and recessive model: OR = 1.24, 95% CI = 0.96–1.60). On subgroup analysis by ethnicity, similarly results were found in both Asians and non-Asians. For Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.07, 95% CI = 0.87–1.32; additive model: OR = 1.15, 95% CI = 0.77–1.71; dominant model: OR = 1.13, 95% CI = 0.92–1.38; and recessive model: OR = 1.09, 95% CI = 0.84–1.40). For none-Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.58, 95% CI = 0.90–2.76; additive model: OR = 2.37, 95% CI = 0.79–7.05; dominant model: OR = 1.79, 95% CI = 0.77–4.19; and recessive model: OR = 1.80, 95% CI = 0.96–3.36).ConclusionThe present meta-analysis suggested that CYP11B2 C-344T polymorphism was unlikely contribute to ischemic stroke susceptibility.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects

Zhang

Chang

et al. 2013

PLoS ONE

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“…Важную роль в развитии ЭД играет РААС [4,5]. Одним из ее компонентов, приводящим к ЭД, является альдостеронсинтаза (CYP11B2) -ключевой энзим для синтеза минералокортикоида альдостерона, выделяемого секреторными клетками в адреналовой зоне надпочечников [6].…”

Section: Introductionunclassified

“…Эти же механизмы играют важную роль в развитии фиброза предсердий, который ассоциируется с фибрилляцией предсердий (ФП) [3][4][5]7]. Orenes-Piñero E. с соавт.…”

Section: Introductionunclassified

Associations of aldosterone synthase gene polymorphism and atrial fibrillation affected by coronary heart disease in elderly and senile patients

Кудрявцева

Филиппов

2019

Medicinskij sovet

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Given the significant increase in the frequency of atrial fibrillation (AF) in elderly and senile patients with confirmed coronary heart disease (CHD), the study of the relationship between the polymorphisms responsible for the functioning of the renin-angiotensinaldosterone system and the presence of this disease becomes relevant. Purpose of the study. To study the genetic polymorphism of the CYP11B2 gene in elderly patients with ischemic heart disease, as well as to identify the role of aldosterone synthetase in the development of AF in this category of patients. Materials and methods. The study included 140 patients of both sexes (54,3% – men), over the age of 60 years, with confirmed coronary artery disease and any form of AF (the last episode no later than 12 months from the date of inclusion in the study). 84 patients agreed to participate in the study of aldosterone synthase polymorphisms. The control group consisted of 34 patients who had no diagnosed non-infectious diseases at the time of the survey. Both groups were comparable in age and sex characteristics. Results. Comparative evaluation of the distribution of genotypes and alleles – C344/T of the aldosterone synthase gene among patients with AF+CHD and relatively healthy individuals revealed that in the first group, most patients had the CYP11B2 T/T genotype in 38,1% of cases, the incidence was higher, than in patients of the comparison group – 14,7% (OR = 3.44, CI 1.07-11.07, p = 0.038). The frequency of detection of genotypes of CYP11B2 С/T and CYP11B2 С/С did not significantly differ in the compared groups. In the group with AF+CHD, the T allele was significantly more common (53,6% vs. 35,3%; p<0,05), while the frequency of occurrence of allele C was significantly higher in the group of relatively healthy individuals (64,3% vs. 47,1%; p<0,05). Conclusion. AF in elderly and senile patients with CHD is associated with the presence of CYP11B2 T/T genotype (OR = 3,44, DI 1,07–11,07, p = 0,038) and is not associated with myocardial echocardiographic parameters, including the size of left atrium.

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Genetic Risk Factors of Intracranial Atherosclerosis

Liu

Gutierrez

2020

Curr Atheroscler Rep

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Association of CYP11B2 gene polymorphism with ischemic stroke in the north Chinese Han population

Abstract: Our findings suggest a significant association of CYP11B2 (-344C/T) polymorphism with stroke but intron 2 polymorphism is not associated with increased stroke susceptibility.

Cited by 11 publications

References 25 publications

Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects

Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects

Associations of aldosterone synthase gene polymorphism and atrial fibrillation affected by coronary heart disease in elderly and senile patients

Genetic Risk Factors of Intracranial Atherosclerosis

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