Association of elevated insulin‐like growth factor binding protein‐1 with insulin resistance in hyperthyroidism

Jenkins, Richard C.; Valcavi, Roberto; Zini, Michele; Frasoldati, Andrea; Heller, Simon; Camacho‐Hübner, Cecilia; Gibson, John M.; Westwood, Melissa; Ross, R. J. M.

doi:10.1046/j.1365-2265.2000.00924.x

Cited by 26 publications

(21 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Smaller studies supported this and showed an increased glucose but also insulin response to an oral glucose tolerance test in patients with subclinical and overt hyperthyroidism [76,77]. When an oral glucose tolerance test is repeated in patients with subclinical or overt hypothyroidism interestingly again glucose and particularly insulin levels are raised supporting insulin resistance under hyperthyroid and hypothyroid conditions.…”

Section: Human Datamentioning

confidence: 71%

Thyroid Hormones and the Metabolic Syndrome

2013

View full text Add to dashboard Cite

Background: Clustering of various metabolic parameters including abdominal obesity, hyperglycaemia, low high-density lipoprotein cholesterol, elevated triglycerides and hypertension have been used worldwide as metabolic syndrome to predict cardiometabolic risk. Thyroid dysfunction impacts on various levels of these components. Objectives: The purpose of the present review is to summarize available data on thyroid hormone-dependent action on components of the metabolic syndrome. Methods: A PubMed search for any combination of hyperthyroidism, thyrotoxicosis or hypothyroidism and metabolic syndrome, blood pressure, hypertension, hyperlipidaemia, cholesterol, high-density lipoprotein cholesterol, glucose, diabetes mellitus, body weight or visceral fat was performed. We included papers and reviews published between 2000 and today but accepted also frequently cited papers before 2000. Results: There is convincing evidence for a major impact of thyroid function on all components of the metabolic syndrome, reflecting profound alterations of energy homeostasis at many levels. Conclusion: Even though the interactions shown in animal models and man are complex, it is evident that insulin sensitivity is highest and adverse thyroid effects on the metabolic system are lowest in euthyroid conditions.

show abstract

Section: Human Datamentioning

confidence: 71%

Thyroid Hormones and the Metabolic Syndrome

2013

View full text Add to dashboard Cite

show abstract

“…There have been a number of studies examining the effects of thyroid status on serum concentrations of IGF-1 and its binding proteins in patients with thyroid dysfunction (1)(2)(3)(4)6,(19)(20)(21)(22). Main results of these in vivo investigations suggest that there is an increase in serum levels of IGF-1 in patients with hyperthyroidism (1,5,19,21,23), and a decrease of these values in patients with hypothyroidism (1,2,3,6).…”

Section: Introductionmentioning

confidence: 92%

Serum Insulin-Like Growth Factor Type 1, Insulin-Like Growth Factor-Binding Protein-1, and Insulin-Like Growth Factor-Binding Protein-3 Concentrations in Patients with Thyroid Dysfunction

Iglesias

Bayón

Méndez

et al. 2001

Thyroid

View full text Add to dashboard Cite

Thyroid hormones play a role in the regulation of insulin-like growth factor type 1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) expression, and both IGF-1 and IGFBPs have been shown to be related to the function and growth of the thyroid. Our aim was to evaluate serum concentrations of IGF-1, IGFBP-1, and IGFBP-3 in patients with thyroid dysfunction before and after normalization of thyroid function. The study was performed in 86 patients with thyroid dysfunction (43 hyperthyroid and 43 hypothyroid patients) and 17 euthyroid subjects. Serum growth hormone (GH), insulin, IGF-1, IGFBP-1, and IGFBP-3 were measured in all patients before and after normalizing serum thyroid hormone concentrations. Hyperthyroid patients showed IGF-1 (198.8 +/- 17.0 microg/L) and IGFBP-3 levels (4.2 +/- 0.2 mg/L) similar to those found in the control group (217.9 +/- 20.3 microg/L and 4.2 +/- 0.3 mg/L, respectively). After therapy these levels significantly decreased to 156.6 + 11.1 microg/L (p < 0.01) and 3.3 +/- 0.1 mg/L (p < 0.001), respectively. IGFBP-1 concentrations were clearly higher than those found in controls (22.7+/- 2.6 vs. 5.7 +/- 1.5 microg/L, p < 0.001) and exhibited a significant reduction after therapy for thyroid hyperfunction (11.0 +/- 1.7 microg/L, p < 0.001). Patients with hypothyroidism showed serum concentrations of IGF-1 (161.5 +/- 13.1 microg/L, p < 0.05) and IGFBP-3 (3.2 +/- 0.3 microg/L, p < 0.05) significantly lower than those found in healthy volunteers. However, replacement therapy with levothyroxine did not induce any significant modification of these concentrations (152.6 +/- 10.6 microg/L and 3.2 +/- 0.2 mg/L, respectively). Similarly, patients with thyroid hypofunction exhibited raised levels of IGFBP-1 (15.5 +/- 0.9 microg/L, p < 0.05 vs. control group) that were significantly decreased after therapy (8.8 +/- 1.4 microg/L, p < 0.01). The results of the present study show that thyroid status affects GH/IGF axis. Hypothyroidism is associated with significant reductions of IGF-1 and IGFBP-3, and IGFBP-1 is elevated in both hypothyroidism and hyperthyroidism.

show abstract

“…There have been a number of studies examining the effects of thyroid status on serum concentrations of IGF-I and its binding proteins in patients with thyroid dysfunction [8][9][10][11][12][13][14][15][16]. Main results of these in vivo investigations suggest that there is an increase in serum levels of IGF-I in patients with hyperthyroidism [8,13,15,17,18], and a decrease of these values in patients with hypothyroidism [8][9][10]12].…”

Section: Introductionmentioning

confidence: 93%

Growth hormone/insulin-like growth factor axis in patients with subclinical thyroid dysfunction

Akın

Yaylalı

Turgut

et al. 2009

Growth Hormone & IGF Research

View full text Add to dashboard Cite

Association of elevated insulin‐like growth factor binding protein‐1 with insulin resistance in hyperthyroidism

Abstract: We conclude that in hyperthyroidism thyroid hormones directly increase fasting IGFBP-1 concentration but acute regulation of IGFBP-1 by insulin is normal and that elevated fasting phosphorylated IGFBP-1 concentration is associated with insulin resistance.

Cited by 26 publications

References 38 publications

Thyroid Hormones and the Metabolic Syndrome

Thyroid Hormones and the Metabolic Syndrome

Serum Insulin-Like Growth Factor Type 1, Insulin-Like Growth Factor-Binding Protein-1, and Insulin-Like Growth Factor-Binding Protein-3 Concentrations in Patients with Thyroid Dysfunction

Growth hormone/insulin-like growth factor axis in patients with subclinical thyroid dysfunction

Contact Info

Product

Resources

About