Association of elevated levels of C-reactive protein with breast cancer, breast cancer subtypes, and poor outcome

Kaur, Raman Preet; Rubal,; Banipal, Raja Paramjeet Singh; Vashistha, Rajesh; Dhiman, Monisha; Munshi, Anjana

doi:10.1016/j.currproblcancer.2018.05.003

Cited by 24 publications

(21 citation statements)

References 20 publications

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“…Multiple studies have, therefore, confirmed that CRP could be used as a prognosis factor ( 36 – 38 ). This has been reported in different tumors including breast cancer ( 39 ), prostate cancer ( 40 ), non-small cell lung cancer ( 41 ), hepatocellular carcinoma ( 42 ), cervical cancer ( 43 ), head and neck squamous cell carcinoma ( 44 ), diffuse large B-cell lymphoma ( 45 ) and osteosarcoma ( 46 ). The specific mechanisms involved are still lacking.…”

Section: C-reactive Proteinmentioning

confidence: 89%

The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression

Wang

Zou

et al. 2020

Front. Immunol.

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The pentraxin is a superfamily of proteins with the same domain known as the pentraxin domain at C-terminal. This family has two subgroups, namely; short pentraxins (C-reactive protein and serum amyloid P component) and long pentraxins (neuronal pentraxin 1, neuronal pentraxin 2, neuronal pentraxin receptor, pentraxin 3 and pentraxin 4). Each group shares a similar structure with the pentameric complexes arranged in a discoid shape. Previous studies revealed the functions of different pentraxin family members. Most of them are associated with human innate immunity. Inflammation has commonly been associated with tumor progression, implying that the pentraxin family might also participate in tumor progression. Therefore, we reviewed the basic characteristics and functions of the pentraxin family and their role in tumor progression.

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Section: C-reactive Proteinmentioning

confidence: 89%

The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression

Wang

Zou

et al. 2020

Front. Immunol.

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“…Particularly, a significant association of state of inflammation with stage of BC was previously described [ 32 ]. A recent study found that elevated serum levels of CRP were associated considerably with a high risk of BC and poor outcome, including metastasis and recurrence [ 33 ]. In addition, the concentrations of SAA4 increased gradually with tumor progression and the severity of BC stages [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Protein Corona Gold Nanoparticles Fingerprinting Reveals a Profile of Blood Coagulation Proteins in the Serum of HER2-Overexpressing Breast Cancer Patients

Chantada-Vázquez

López

García-Vence

et al. 2020

IJMS

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Breast cancer (BC) is a molecularly heterogeneous disease that encompasses five major molecular subtypes (luminal A (LA), luminal B HER2 negative (LB-), luminal B HER2 positive (LB+), HER2 positive (HER2+) and triple negative breast cancer (TNBC)). BC treatment mainly depends on the identification of the specific subtype. Despite the correct identification, therapies could fail in some patients. Thus, further insights into the genetic and molecular status of the different BC subtypes could be very useful to improve the response of BC patients to the range of available therapies. In this way, we used gold nanoparticles (AuNPs, 12.96 ± 0.72 nm) as a scavenging tool in combination with Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH-MS) to quantitatively analyze the serum proteome alterations in the different breast cancer intrinsic subtypes. The differentially regulated proteins specific of each subtype were further analyzed with the bioinformatic tools STRING and PANTHER to identify the major molecular function, biological processes, cellular origin, protein class and biological pathways altered due to the heterogeneity in proteome of the different BC subtypes. Importantly, a profile of blood coagulation proteins was identified in the serum of HER2-overexpressing BC patients.

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“…Chronic inflammation is critically linked with clinical outcomes such as mortality in those diagnosed with breast cancer ( Pierce et al , 2009 ). Circulating markers of peripheral inflammation, such as C-reactive protein (CRP), are considered important prognostic markers tied to a variety of cancer-related outcomes in breast cancer survivors, including fatigue, tumor progression, cancer recurrence and overall mortality ( Pierce et al , 2009 ; Orre et al , 2011 ; Kaur et al , 2019 ). Experiences of both acute and chronic psychological stress have been shown to be related to elevated levels of circulating markers of inflammation ( Danese et al , 2007 ; Steptoe et al , 2007 ).…”

Section: Introductionmentioning

confidence: 99%

“…For example, CRP has been linked with various outcomes related to breast cancer, the most prevalent cancer in women worldwide. Elevated CRP is associated with cancer metastasis ( Kaur et al , 2019 ), as well as increased overall mortality ( Pierce et al , 2009 ), in those diagnosed with breast cancer. Even within breast cancer survivors who are considered disease-free, CRP remains linked with cancer-related clinical and behavioral outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…Even within breast cancer survivors who are considered disease-free, CRP remains linked with cancer-related clinical and behavioral outcomes. Elevated CRP is associated with increased likelihood of cancer recurrence ( Pierce et al , 2009 ; Kaur et al , 2019 ), as well as greater levels of fatigue ( Orre et al , 2011 ). Thus, CRP is associated with a variety of outcomes related to breast cancer, particularly post-treatment, and is thus an important prognostic marker for breast cancer survivors in particular.…”

Section: Introductionmentioning

confidence: 99%

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Associations between amygdala reactivity to social threat, perceived stress and C-reactive protein in breast cancer survivors

Leschak

Dutcher

Haltom

et al. 2020

Social Cognitive and Affective Neuroscience

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Abstract Chronic inflammation in women diagnosed with breast cancer is critically linked with tumor progression, metastasis and survival. C-reactive protein (CRP)—a circulating marker of inflammation—is an important prognostic marker for cancer-related outcomes in breast cancer survivors (e.g. recurrence, fatigue). Psychological stress, which increases circulating markers of inflammation following sympathetic nervous system (SNS) activation, may modulate tumor-relevant inflammatory processes. However, little is known about neural mechanisms that might link stress and downstream SNS-initiated proinflammatory processes, such as elevated CRP. Past work suggests that threat-related neural regions, such as the amygdala, may be key in translating psychological stress into SNS activity and subsequent peripheral inflammation. Thus, we examined amygdala reactivity to socially threatening stimuli in association with perceived stress and plasma CRP levels to further elucidate neuro-immune pathways of social threat processing within breast cancer survivors (N = 37). Significant positive correlations were found between left amygdala reactivity in response to socially threatening stimuli (e.g. angry/fearful faces vs happy faces) and perceived stress in the previous month (r = 0.32, P = 0.025) and between left amygdala reactivity and CRP (r = 0.33, P = 0.025). This work builds on prior research implicating the amygdala as a key structure in crosstalk between threat-related neural circuitries and peripheral inflammation, particularly within cancer survivors.

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Association of elevated levels of C-reactive protein with breast cancer, breast cancer subtypes, and poor outcome

Cited by 24 publications

References 20 publications

The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression

The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression

Protein Corona Gold Nanoparticles Fingerprinting Reveals a Profile of Blood Coagulation Proteins in the Serum of HER2-Overexpressing Breast Cancer Patients

Associations between amygdala reactivity to social threat, perceived stress and C-reactive protein in breast cancer survivors

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