The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression

Wang, Zeyu; Wang, Xing; Zou, Hecun; Dai, Ziyu; Feng, Shi Ting; Zhang, Mingyu; Xiao, Gelei; Zhi-xiong, Liu; Cheng, Quan

doi:10.3389/fimmu.2020.01757

Cited by 50 publications

(56 citation statements)

References 137 publications

(147 reference statements)

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“…In addition, EphA3 is highly expressed in tumors, but not in normal tissues, which, together with antitumor properties of anti-EphA3mAb (chIIIA4), defined EphA3 as a potential target for antibody-based anticancer therapies (23). PTX3 is secreted by dendritic cells, macrophages, and fibroblasts and is actively involved in the regulation of inflammation, tissue remodeling, and cancer (24). PTX3 interacts with the PI3K/AKT/mTOR signaling pathway or the fibroblast growth factor-2/receptor system to regulate tumor cell proliferation, apoptosis, and metastasis in lung cancer, breast cancer, melanoma, prostate cancer, and multiple myeloma (24,25).…”

Section: Discussionmentioning

confidence: 99%

International Prognostic Index-Based Immune Prognostic Model for Diffuse Large B-Cell Lymphoma

Shi

et al. 2021

Front. Immunol.

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BackgroundThe International Prognostic Index (IPI) is widely used to discriminate the prognosis of patients with diffuse large B-cell lymphoma (DLBCL). However, there is a significant need to identify novel valuable biomarkers in the context of targeted therapy, such as immune checkpoint blockade (ICB).MethodsGene expression data and clinical DLBCL information were obtained from The Cancer Genome Atlas and Gene Expression Omnibus datasets. A total of 371 immune-related genes in DLBCL patients associated with different IPI risk groups were identified by weighted gene co-expression network analysis, and eight genes were selected to construct an IPI-based immune prognostic model (IPI-IPM). Subsequently, we analyzed the somatic mutation and transcription profiles of the IPI-IPM subgroups as well as the potential clinical response to immune checkpoint blockade (ICB) in IPI-IPM subgroups.ResultsThe IPI-IPM was constructed based on the expression of CMBL, TLCD3B, SYNDIG1, ESM1, EPHA3, HUNK, PTX3, and IL12A, where high-risk patients had worse overall survival than low-risk patients, consistent with the results in the independent validation cohorts. The comprehensive results showed that high IPI-IPM risk scores were correlated with immune-related signaling pathways, high KMT2D and CD79B mutation rates, and upregulation of inhibitory immune checkpoints, including PD-L1, BTLA, and SIGLEC7, indicating a greater potential response to ICB therapy.ConclusionThe IPI-IPM has independent prognostic significance for DLBCL patients, which provides an immunological perspective to elucidate the mechanisms of tumor progression and sheds light on the development of immunotherapy for DLBCL.

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Section: Discussionmentioning

confidence: 99%

International Prognostic Index-Based Immune Prognostic Model for Diffuse Large B-Cell Lymphoma

Shi

et al. 2021

Front. Immunol.

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“…Also, EphA3 high expression in tumors but not in normal tissues, together with antitumor properties of anti-EphA3mAb (chIIIA4), defined EphA3 as a potential target for antibody-based anticancer therapies 61 . PTX3 is secreted by dendritic cells, macrophages, and fibroblasts, and actively involved in regulation of inflammation, tissue remodeling and cancer 62 . PTX3 interacts with the PI3K/AKT/mTOR signaling pathway or the fibroblast growth factor-2 (FGF2) / FGF receptor (FGFR) system to regulate tumor cell proliferation, apoptosis and metastasis in lung cancer, breast cancer, melanoma, prostate cancer and multiple myeloma 62, 63 .…”

Section: Discussionmentioning

confidence: 99%

“…PTX3 is secreted by dendritic cells, macrophages, and fibroblasts, and actively involved in regulation of inflammation, tissue remodeling and cancer 62 . PTX3 interacts with the PI3K/AKT/mTOR signaling pathway or the fibroblast growth factor-2 (FGF2) / FGF receptor (FGFR) system to regulate tumor cell proliferation, apoptosis and metastasis in lung cancer, breast cancer, melanoma, prostate cancer and multiple myeloma 62, 63 . IL12A is a potent immune suppressive cytokine produced by regulatory B (Breg) cells, Treg cells, macrophages, dendritic cells and tumor cells, which suppresses the effector functions of CD4 + and CD8 + T cells but strongly favors Tregs proliferation 64 .…”

Section: Discussionmentioning

confidence: 99%

An IPI based immune prognostic model for diffuse large B-cell lymphoma

Shi

et al. 2021

Preprint

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Background: An enhanced International Prognostic Index (NCCN-IPI) was built to better discriminate diffuse large B-cell lymphoma (DLBCL) patients in the rituximab era. However, there is an urgent need to identify novel valuable biomarkers in the context of targeted therapies, such as immune checkpoint blockade (ICB) therapy. Methods: Gene expression data and clinical information were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. 73 immune-related hub genes in DLBCL patients with different IPI levels were identified by weighted gene co-expression network analysis (WGCNA), and 4 genes were selected to construct an IPI-based immune-related prognostic model (IPI-IPM). Afterward, the genetic, somatic mutational and molecular profiles of IPI-IPM subgroups were analyzed, as well as the potential clinical response of ICB in different IPI-IPM subgroups. Results: The IPI-IPM was constructed base on the expression of LCN2, CD5L, NLRP11 and SERPINB2, where high-risk patients had shorter overall survival (OS) than low-risk patients, consistent with the results in the GEO cohorts. The comprehensive results showed that a high IPI-IPM risk score was correlated with immune-related signaling pathways, high KMT2D and CD79B mutation rates, high infiltration of CD8+ T cells and macrophages (M1, M2), as well as up-regulation of inhibitory immune checkpoints including PD-L1, LAG3 and BTLA, indicating more potential response to ICB therapy. Conclusion: The IPI-IPM has independent prognostic significance for DLBCL patients, which provides an immunological perspective to elucidate the mechanisms on tumor progression and drug resistance, also sheds a light on developing immunotherapy for DLBCL.

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“…PTX4 is reported to be widely expressed at low levels, with the highest levels in the liver in mice, and the small intestine and testes in humans [49], however, expression in sheep has been detected primarily in the cerebellum, at low levels [37,50]. PTX4 belongs to the pentraxin (PTX) superfamily of multifunctional conserved proteins; some PTXs are part of the humoral arm of innate immunity and behave as functional ancestors of antibodies by medi-ating agglutination and complement activation, however, PTX4 mRNA expression is distinct from other PTX family members [49], and there is no current evidence supporting the function of PTX4 in innate immunity [51].…”

Section: Discussionmentioning

confidence: 99%

Genomic Tools for the Identification of Loci Associated with Facial Eczema in New Zealand Sheep

McRae

Rowe

Johnson

et al. 2021

Genes

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Facial eczema (FE) is a significant metabolic disease that affects New Zealand ruminants. Ingestion of the mycotoxin sporidesmin leads to liver and bile duct damage, which can result in photosensitisation, reduced productivity and death. Strategies used to manage the incidence and severity of the disease include breeding. In sheep, there is considerable genetic variation in the response to FE. A commercial testing program is available for ram breeders who aim to increase tolerance, determined by the concentration of the serum enzyme, γ-glutamyltransferase 21 days after a measured sporidesmin challenge (GGT21). Genome-wide association studies were carried out to determine regions of the genome associated with GGT21. Two regions on chromosomes 15 and 24 are reported, which explain 5% and 1% of the phenotypic variance in the response to FE, respectively. The region on chromosome 15 contains the β-globin locus. Of the significant SNPs in the region, one is a missense variant within the haemoglobin subunit β (HBB) gene. Mass spectrometry of haemoglobin from animals with differing genotypes at this locus indicated that genotypes are associated with different forms of adult β-globin. Haemoglobin haplotypes have previously been associated with variation in several health-related traits in sheep and warrant further investigation regarding their role in tolerance to FE in sheep. We show a strategic approach to the identification of regions of importance for commercial breeding programs with a combination of discovery, statistical and biological validation. This study highlights the power of using increased density genotyping for the identification of influential genomic regions, combined with subsequent inclusion on lower density genotyping platforms.

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The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression

Cited by 50 publications

References 137 publications

International Prognostic Index-Based Immune Prognostic Model for Diffuse Large B-Cell Lymphoma

International Prognostic Index-Based Immune Prognostic Model for Diffuse Large B-Cell Lymphoma

An IPI based immune prognostic model for diffuse large B-cell lymphoma

Genomic Tools for the Identification of Loci Associated with Facial Eczema in New Zealand Sheep

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