Association of Fetuin-B with Subclinical Atherosclerosis in Obese Chinese Adults

Li, Zhibin; Cai, He; Liu, Yongwen; Wang, Dongmei; Lin, Mingzhu; Liu, Changqin; Shi, Xiulin; Chen, Zheng; Li, Xuejun; Yang, Shuyu; Li, Weihua

doi:10.5551/jat.49619

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…FBLN1 is abundant in the plasma and arterial walls of patients with type 2 diabetes and can be used as a predictor of cardiovascular mortality in patients with type 2 diabetes [41]. An independent risk factor for type 2 diabetes is the plasma levels of AHSG, which is an insulin receptor inhibitor secreted by the liver and, along with FETUB [42,43], thought to be an important factor in insulin resistance in obesity [44,45]. GPLD1 serves as a biomarker that effectively differentiates latent autoimmune diabetes in adults from type 2 diabetes in the early stage [46], and it was shown that the circulating GPLD1 concentration in diabetic rats could be restored to normal levels by exercise training [47].…”

Section: Discussionmentioning

confidence: 99%

DIA-Based Proteomic Analysis of Plasma Protein Profiles in Patients with Severe Acute Pancreatitis

Zhou

et al. 2022

Molecules

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Acute pancreatitis (AP) is a pancreatic inflammatory disease that varies greatly in course and severity. To further the understanding of the pathology of AP, we carried out data-independent acquisition-based proteomic analyses using proteins extracted from the plasma of patients with severe acute pancreatitis (SAP) (experimental group) and healthy volunteers (control group). Compared to the control group, there were 35 differentially expressed proteins (DEPs) in the plasma of patients with SAP. Of those, the expression levels for 6 proteins were significantly increased, and 29 proteins were significantly decreased. Moreover, six candidate biomarkers—VWF, ORM2, CD5L, CAT, IGLV3-10, and LTF—were matched as candidate biomarkers of the disease severity of AP. The area under the receiver operating characteristic of 0.903 (95% CI: 0.839, 0.967) indicated that this combination of these six candidate biomarkers had a good prediction accuracy for predicting the severity of AP. Our study provides specific DEPs that may be useful in the diagnosis and prognosis of SAP, which suggests new theoretical bases for the occurrence and development of SAP and offers potential novel treatment strategies for SAP.

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Section: Discussionmentioning

confidence: 99%

DIA-Based Proteomic Analysis of Plasma Protein Profiles in Patients with Severe Acute Pancreatitis

Zhou

et al. 2022

Molecules

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“…In the present study, we found that CIMT was increased in PCOS subjects compared to controls. Growing evidence suggest that there is a link between fetuin-B and cardiovascular disorders [9,24]. Moreover, fetuin-B increases inflammation in vascular plaque and also causes vascular plaque vulnerable [10].…”

Section: Discussionmentioning

confidence: 99%

Increased fetuin-B levels are associated with carotid intima media thickness and hormonal-metabolic disturbances in women with polycystic ovary syndrome

Bayındır¹,

Ünal²,

İmamoğlu³

et al. 2020

Zeynep Kamil Tıp Bülteni

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Objective: Fetuin-B is a novel peptide hormone involves in energy metabolism, atherosclerosis and reproductive system. Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder associated with increased cardiovascular risk factors. We aimed to ascertain whether circulating fetuin-B levels were altered in women with PCOS and whether there was any association between fetuin-B and hormonal-metabolic parameters as well as carotid intima media thickness (CIMT). Material and Methods: Eighty women with PCOS and 80 ageand BMI-matched controls without PCOS were recruited to this cross-sectional study. Circulating fetuin-B levels were measured by ELISA. Metabolic-hormonal parameters and CIMT of recruited subjects were also determined. Results: Circulating fetuin-B levels were significantly elevated in women with PCOS compared to controls (409.54 ± 32.51 vs. 325.53 ± 26.86 ng/ml, P<0.001). PCOS subjects with insulin resistance showed significantly elevated circulating fetuin-B levels compared to those PCOS subjects without insulin resistance (416.03 ± 30.41 vs. 399.27 ± 33.56 ng/ml, P = 0.024). Overweight/obese women had significantly higher circulating fetuin-B levels than lean subjects in PCOS groups (416.32 ± 30.99 vs. 400.82 ± 32.77 ng/ml, P = 0.033). Fetuin-B levels positively correlated with BMI, homeostasis model assessment of insulin resistance (HOMA-IR), free-androgen index (FAI), high sensitivity C-reactive protein (hs-CRP), triglycerides and CIMT in PCOS subjects whereas fetuin-B negatively correlated with high density lipoprotein cholesterol (HDL-C). Moreover, binary logistic regression analysis revealed that the risk of having PCOS was increased in parallel with elevation of fetuin-B levels. Conclusion: Circulating fetuin-B levels were significantly increased in PCOS subjects and fetuin-B levels were closely related to cardiovascular risk and hormonal-metabolic disturbances in women with PCOS.

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“…In patients with OSA, the risk of hypertension [ 2 ], treatment resistance [ 3 ], ischemic heart disease [ 4 ], cardiovascular events, arrhythmias, heart failure [ 2 ], stroke [ 5 ], neurodegenerative diseases, and poor cognitive performance [ 6 ] is increased. One of the agents known to be involved in atherogenesis is Fetuin-A (Fet-A) [ 7 , 8 ]. Produced in the liver, Fet-A is a glycoprotein that limits the calcification of the vessels [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Level of Serum Fetuin-A Correlates with Heart Rate in Obstructive Sleep Apnea Patients without Metabolic and Cardiovascular Comorbidities

Reichert¹,

Mosiewicz

Myśliński

et al. 2022

IJERPH

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Obstructive sleep apnea (OSA) is the most common type of sleep-induced breathing disorder in the adult population and significantly affects the condition of the cardiovascular system. Fetuin-A (Fet-A) is a hepato- and adipokine, which prevents vessel calcification, and its level correlates with atherogenesis and metabolic disorders. The associations of cardiovascular diseases (CVD) both with OSA, which increases CVD risk, and Fet-A, which prevents CVD, justify the question of their mutual interactions in patients with OSA. Therefore, we sought to analyze Fet-A as an early biomarker of CVD risk in OSA patients without metabolic and cardiovascular comorbidities except for properly controlled arterial hypertension. We have found that in these patients, OSA does not appear to directly affect Fet-A levels. However, high Fet-A levels were more common in the group of patients with OSA, and the hypopnea index was significantly higher among subjects with the highest Fet-A levels. The level of Fet-A in OSA patients positively correlates with pulse rate, and it does not correlate with pulse pressure in this group unlike in the control group, where such a relationship exists. To our best knowledge, this is the first study to analyze this relationship in OSA patients without any significant cardiovascular comorbidities.

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Association of Fetuin-B with Subclinical Atherosclerosis in Obese Chinese Adults

Cited by 8 publications

References 25 publications

DIA-Based Proteomic Analysis of Plasma Protein Profiles in Patients with Severe Acute Pancreatitis

DIA-Based Proteomic Analysis of Plasma Protein Profiles in Patients with Severe Acute Pancreatitis

Increased fetuin-B levels are associated with carotid intima media thickness and hormonal-metabolic disturbances in women with polycystic ovary syndrome

Level of Serum Fetuin-A Correlates with Heart Rate in Obstructive Sleep Apnea Patients without Metabolic and Cardiovascular Comorbidities

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