Association of Fut1 and Slc11a1 gene polymorphisms with productivity traits of Large White pigs

Abstract

The purpose of our work was to study the polymorphism of genes associated with disease resistance and to search for their associations with productive traits in the population of the Ukrainian Large White pigs. For this study, 50 pigs were used, observations and measurements were carried out at the age from birth to 180 days. Genetic studies were carried out in a certified laboratory of the Institute of Pig Breeding and Agroindustrial Production. In the study of fucosyltransferase 1 and solute carrier family 11 member 1 genes, polymorphism was found in three of the five analyzed loci. In the Ukrainian Large White subpopulation of pigs the informativeness of these gene polymorphisms was at the optimal level for associative analysis, Polymorphism Information Content was greater than 0.3 in two loci. A sufficiently high level of Polymorphism Information Content indicates the value of this breed to preserve the biodiversity of pigs. The distribution of genotypes at some loci of the solute carrier family 11 member 1 gene was characterized by a deviation from the theoretically expected one due to the increase in the frequency of the heterozygous genotype. There was also a statistically confirmed deviation of the genotypes’ distribution from the normal and polymorphism fucosyltransferase 1 gene, but in this case in the direction of increasing the frequency of both homozygous variants. These results indicate the presence of a certain selection pressure on the mentioned polymorphisms and their possible impact on productive traits. The influence of solute carrier family 11 member 1 gene polymorphism on the weight of pigs at the age of 120 and 180 days, the average daily gain recorded in the period 28–120 days and from birth to 180 days, as well as on the backfat thickness, was established. The preferred genotype is TT, which can be used in breeding to obtain more productive animals with increased disease resistance, but in the selection of animals at this locus, it is necessary to control the backfat thickness and prevent breeding of pigs that may worsen this trait.

Оцінка Молодняку Свиней Різних Генотипів За Селекційними Індексами Та Показниками Росту

“…Генетичні фактори можуть досліджуватись як вплив сумарного (адитивного) генотипу тварин в межах певної генетичної групи, таких як порода, лінія тощо [12][13][14][15]. Проте, більш правильним, на думку ряду науковців [16][17][18] є дослідження впливу генетичних факторів за окремими генами та ДНК-маркерами. Серед генетичних маркерів, що представляють інтерес для галузі свинарства досить добре дослідженим є MC4R c.1426 G>A SNP (ген рецептора меланокортина 4), який асоціюється із харчовою поведінкою, величиною середньодобових приростів та товщиною шпику свиней [19,20].…”

The influence of feeding level on the growth of pigs depending on their genotype

“…One of the peculiarities of the metabolism of pigs of Ukrainian selection is their propensity for significantly greater accumulation of backfat compared to pigs of the same breeds of European origin (Vashchenko et al, 2019;Sukhno et al, 2022;Vashchenko et al, 2022). Both nongenetic factors, such as pig feeding system (Lebret, 2008;Bankovska et al, 2020) or environmental temperature (Vashchenko & Berezovskyi, 2021) and genetic factors, such as MC4R genotype (Kim et al, 2000;Fan et al, 2009;Loos & Yeo, 2022), influence the intensity of growth and deposition of backfat.…”

Signs of Feeding and Meat Qualities of Young Pigs of Diverse Interbreed Differentiation According to the Eurosomy Index and Their Level of Discretion

“…The maximum increase in additional production was obtained from young pigs of the 1st experimental group -+2.35%, and its value are +162.47 hryvnias or 4.11 US dollars. Інтенсифікація виробництва високоякісної свинини в Україні передбачає, поряд з покращенням умов годівлі та утримання тварин, впровадження інноваційних методів оцінки племінної цінності, відбір високопродуктивних тварин та інтенсивне їх використання (Topchii, 2007;Kovalenko, 2011;Voloshchuk et al, 2020;Lykhach et al, 2021;Verbych & Bratkovska, 2022). Зазначене лежить в основі селекційно-племінної роботи з вітчизняними породами та тваринами, які одержані шляхом внутрішньопородного поєднання свиноматок української селекції з кнурами зарубіжного походження.…”