Association of G197 Polymorphism of IL-17A Gene with Myocardial Remodeling and Aerobic Performance in Athletes

Abstract

We studied the relationship between G197A polymorphism of IL-17A gene and changes in morphometric echocardiography parameters and physiological parameters in skiers (19 examinees). Genotyping was performed by restriction fragment length polymorphism analysis and echocardiography using a Nemio MX ultrasound scanner (Toshiba). Association of 197A allele of IL-17A gene with low myocardial growth and high aerobic performance of athletes was demonstrated.

Association between interleukin 17A gene polymorphisms and risk of coronary artery disease

“…Recently, many studies have assessed the association between IL17A and susceptibility to many cardiovascular diseases (Zeng et al, 2013;Erbel et al, 2014;Lifanov et al, 2014;VargasAlarcón et al, 2015;Mormile, 2015;Wang et al, 2015). Based on an experimental investigation, Vargas-Alarcón et al (2015) reported that the IL17A gene is involved in inflammatory immune responses and neuronal damage, including premature coronary diseases.…”

“…Based on an experimental investigation, Vargas-Alarcón et al (2015) reported that the IL17A gene is involved in inflammatory immune responses and neuronal damage, including premature coronary diseases. In addition, Lifanov et al (2014) reported an association between the 197A allele of the IL17A gene and low myocardial growth in athletes, suggesting that they have a pathogenetic function in this disease. Erbel et al (2014) reported that functional blockade of IL17A prevents atherosclerotic lesion.…”