Association of Gc-globulin variation with susceptibility to COPD and diffuse panbronchiolitis

Ishii, Takashi; Keicho, Naoto; Teramoto, Shinji; Azuma, Arata; Kudoh, Shoji; Fukuchi, Yoshinosuke; Ouchi, Yasuyoshi; Matsuse, Takeshi

doi:10.1183/09031936.01.00094401

Cited by 60 publications

(57 citation statements)

References 30 publications

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“…GC*1F, GC*1S and GC*2 are not alleles as such, but haplotypes composed of combinations of the SNPs at these loci, so an individual may be homozygous or heterozygous for each variant, depending on the two haplotypes present. The role of GC polymorphisms in COPD has been explored in a number of studies by investigating the association of GC variants and susceptibility of COPD (9,10,(19)(20)(21)(22)(23)(24)(25). However, the results of these studies were inconclusive and may not be powerful enough due to the limited sample size.…”

Section: Introductionmentioning

confidence: 76%

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Vitamin D-binding protein gene polymorphisms and chronic obstructive pulmonary disease susceptibility: A meta-analysis

et al. 2014

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Section: Introductionmentioning

confidence: 76%

“…1). As for ethnicity, seven studies investigated the Caucasian population (21,(23)(24)(25)31,32) and five studies investigated the Asian population (9,10,19,20,22). The qualities of these studies were considered accessible for the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Vitamin D-binding protein gene polymorphisms and chronic obstructive pulmonary disease susceptibility: A meta-analysis

et al. 2014

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“…There are some studies in the literature investigating the association of VDBP polymorphisms with the development of COPD; however, contradictory results have been reported for COPD patients of different ethnicities or even within the same ethnic group [8,[17][18][19][20][21]. Individuals who have one or two copies of allele 2 have been shown to be protected against to COPD [17,19,20], whereas the 1F-1F genotype has been associated with increased risk [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

“…Individuals who have one or two copies of allele 2 have been shown to be protected against to COPD [17,19,20], whereas the 1F-1F genotype has been associated with increased risk [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

VDBP Gene Polymorphism in COPD

Soyyiğit¹,

Baykara²,

Buyru³

et al. 2013

Med-Science

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“…Horne et al (1990) first reported that GC gene polymorphisms are associated with chronic bronchitis and emphysema in Caucasians. Associations between GC gene polymorphisms and chronic obstructive pulmonary disorder (COPD) have been established over the past decade (Ishii et al, 2001;Laufs et al, 2004;Ito et al, 2004;Lu et al, 2004;Korytina et al, 2006;Shen et al, 2010). However, the GC gene was not identified as a candidate gene for COPD in recent genome-wide association studies (GWAS) (Artigas et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis

et al. 2015

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ABSTRACT. Vitamin D-binding protein (DBP), a highly polymorphic serum protein, encoded by GC gene, is important in the development of chronic obstructive pulmonary disease (COPD). This meta-analysis was performed to assess the association between GC polymorphisms (1F, 1S, and 2 alleles) and COPD susceptibility. Published case-control studies were retrieved from the Pubmed, Embase, and China National Knowledge Infrastructure databases. After data extraction, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Seven case-control studies were included. Pooled effect size showed that GC polymorphisms were not significantly associated with COPD susceptibility. According to ethnicity, the 1F allele was significantly correlated with COPD susceptibility in Asians (1F vs 1S, OR: 1.52, 95%CI: 1.16-2.00 and 1F vs 2, OR: 1.87, 95%CI: 1.42-2.44), indicating that individuals with the 1F allele have an increased risk of COPD compared to those with the 1S or 2 allele. However, the 1F allele was associated with a lower, insignificant risk of COPD than the 1S and 2 alleles in Caucasians (1F vs 1S, OR: 0.83, 95%CI: 0.64-1.08 and 1F vs 2, OR: 0.73, 95%CI: 0.54-0.98). Moreover, no significant association was found for the 1S and 2 alleles in Asians (OR: 1.23, 95%CI: 0.90-1.69) and Caucasians (OR: 0.89, 95%CI: 0.70-1.13). After excluding each study, the pooled results were robust and no publication bias was observed. We found that the GC 1F allele confers a risk of COPD in Asians, whereas the 1F allele may protect against COPD in Caucasians.

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Association of Gc-globulin variation with susceptibility to COPD and diffuse panbronchiolitis

Cited by 60 publications

References 30 publications

Vitamin D-binding protein gene polymorphisms and chronic obstructive pulmonary disease susceptibility: A meta-analysis

Vitamin D-binding protein gene polymorphisms and chronic obstructive pulmonary disease susceptibility: A meta-analysis

VDBP Gene Polymorphism in COPD

Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis

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