Association of Genetic Marker HLA-B27 with Spondyloarthritis In A Tertiary Care Centre In South India

Thulukanam, Jayaprakash; Muthamilan, Om Lokesh; Leela, K.V.; Rajendran, C. P.; Murugan, Arul Raja; Ravi, Sujith

doi:10.22207/jpam.16.2.10

Cited by 3 publications

(5 citation statements)

References 22 publications

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“…Additionally, it has gradually come to be known that symptoms often persist for years before a disease is identified. [3][4][5] The disease occurs in the second or third decade of life and affects men more frequently than women (ranging from 2.6:1 to 5:1). 4,6 SpA was shown to be 12% more common among first-degree relatives of the affected patients.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] The disease occurs in the second or third decade of life and affects men more frequently than women (ranging from 2.6:1 to 5:1). 4,6 SpA was shown to be 12% more common among first-degree relatives of the affected patients. 5,7 In the pathogenesis of the disease, HLA-B27 plays an important role.…”

Section: Introductionmentioning

confidence: 99%

“…10,11,14 In seronegative spondylarthritis (SSpA) patients, the association of HLA-B27 ranges from 19 to 94%, while it is 1.4 to 8% in the general Indian population. 4,15,16 Seronegative spondylarthritis is characterized by the rheumatoid factor (RF), anti-cyclic citrullinated peptide (Anti-CCP), HLA-B27, or sacroiliitis on a scan in a patient with rheumatoid arthritislike clinical symptoms. In the South Indian population, B*27:05 and B*27:04 subtypes of SpA are the most often seen.…”

Section: Introductionmentioning

confidence: 99%

“…In the South Indian population, B*27:05 and B*27:04 subtypes of SpA are the most often seen. 4,17,18 Due to numerous genetic and environmental factors that affect the disease, there may be variations in the clinical features of AS in different populations, along with variations in the frequency of HLA-B27. It has been suggested that in countries with lower incomes, AS may manifest earlier in life and with more frequent involvement of peripheral joints.…”

Section: Introductionmentioning

confidence: 99%

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Frequent Cases of Spondylarthritis and Hereditary Propensity (HLA-B27) in the Same Family Name Relatives from the Keda Region of Ajara, Georgia

Tsintsadze,

Tsivadze,

Kakhidze

et al. 2023

Georgian Biomedical News

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Background: Typical clinical characteristics of spondyloarthropathies (SpA) include inflammatory back pain (caused by sacroiliitis and peripheral oligoarthritis), enteropathy, anterior uveitis, and an association with HLA-B27. The disease begins in the second or third decade of life and affects more men than women. The prevalence of SpA among first-degree relatives of the affected patients was found to be 12%. Ankylosing spondylitis (AS) is the most common subgroup of SpA, with a crucial role for HLA-B27 in the pathogenesis. HLA-B27 presents in 88-90% of AS patients, compared to 4-8% among the general population. Objectives: In this study, we explored the relationship and hereditary propensity of the same family name relatives from the Keda region of Ajara, Georgia, where we frequently encountered cases of ankylosing spondylitis. Methods: The study was conducted at the Clinic "SoloMed" and "Merlab" Laboratory Services from 05.01-10.03, 2023, using real-time polymerase chain reaction (PCR). Results: Among the 105 evaluated participants included in this study (average age of 40.5 [15-60] years), 53.33% (n=56) were females, and 46.67% (n=49) were males. The highly HLA-B27-positive individuals were six males aged ≥56 years and two women between the ages of 26 and 35. In the relatives with the same family names, 14.29% (n=15) were HLA-B27 positive. Conclusions: The same family name relatives from the Keda region of Ajara, Georgia, showed a considerably higher risk of the distribution of ankylosing spondylitis (14.29).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Frequent Cases of Spondylarthritis and Hereditary Propensity (HLA-B27) in the Same Family Name Relatives from the Keda Region of Ajara, Georgia

Tsintsadze,

Tsivadze,

Kakhidze

et al. 2023

Georgian Biomedical News

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“…6,7 Identification of HLA-B27 has been considered a genetic marker that significantly aids in detecting illness. [8][9][10] The correlation between ankylosing spondylitis and HLA B27 was initially noted in 1973 11 and subsequently proven to be connected to different forms of spondyloarthritis by many researchers. 12 Moreover, having a solid interrelation with AS and spondyloarthritis, HLA-B27 is critical to the pathophysiology of the illness.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Interleukin-17 and 23 Inflammatory Markers with Genetically Transmitted Spondyloarthritis Patients at a Tertiary Care Facility, South India

Thulukanam¹,

Leela²,

Venkatesan³

et al. 2023

J. Pure Appl. Microbiol.

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Human leukocyte antigens (HLA) are genetically derived proteins in the major histocompatibility complex. They help distinguish “self” and “non-self” antigens and are essential in interacting with the immune cells inside the body. The present research work examines the prevalence of HLA-B27 among patients suspected of Spondyloarthritis (SpA), which has also been correlated with Interleukin-17/23 Inflammatory Markers and other clinical manifestations and was carried out between August 2017 to January 2021. The patient’s blood samples were collected and tested for HLA-B27 and Interleukin-17/23 inflammatory markers. Among 289 SpA patients, 60% (172) were males, and 40% (117) were females, with a ratio of 1.5:1. Ankylosing Spondylitis (65.1%) was found to be the most prevalent subgroup of SpA among the patients, closely followed by reactive arthritis (21%), psoriatic arthritis (10.7%), undifferentiated spondyloarthritis (2.1%), and inflammatory bowel disease with associated arthritis (1%). HLA-B27 was found to be positive in 54% (156) out of 289 patients. Normal IL-17 ranges were seen in 42% of HLA-B27- positive patients, while increased IL-17 was seen in 58% of the population with positive HLA-B27 cases. IL-23 was found within normal ranges in 40% of positive HLA-B27 cases, while it was found to be increased in 60% of the positive HLA-B27 positive subjects. We concluded that HLA-B27 was found to be positive among more than half of the patient population with SpA. The early detection of HLA-B27 may aid in changing lifestyle to prevent Spondyloarthritides.

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To study magnetic resonance imaging findings and inflammatory markers in inflammatory sacroiliitis

Singh,

Arora,

Arora

et al. 2023

IJMSR

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Objectives: The objectives of the study are to determine magnetic resonance imaging (MRI) findings in inflammatory sacroiliitis and assign scores and grades to it and to determine and correlate erythrocyte sedimentation rate, C-reactive protein (CRP), and human leukocyte antigen-B27 (HLA-B27) in various grades of sacroiliitis. Material and Methods: An observational cross-sectional study was conducted on 30 patients who clinically presented with features of sacroiliitis and underwent an MRI of sacroiliac joint (SIJ). Various inflammatory and structural findings on MRI were used to do Spondyloarthritis Research Consortium of Canada scoring and grading. Then inflammatory markers including erythrocyte sedimentation rate, CRP, and HLA-B27 were studied in various grades of sacroiliitis. Results: Inflammatory sacroiliitis affects commonly the age group of 21–40 years. Periarticular edema was the most common finding seen with the iliac aspect more commonly involved. The majority of the subjects were graded moderate (50%). Values of erythrocyte sedimentation rate and CRP levels were raised whereas HLA-B27 was positive in 9 patients (30%) of inflammatory sacroiliitis. Conclusion: Inflammatory sacroiliitis presents with a chief complaint of low back ache. MRI helps to grade it into mild, moderate, and severe. STIR is the most sensitive sequence for the detection of bone marrow edema with bilateral symmetrical involvement but the iliac bone of SIJ is more involved than the sacral side. Contrast-enhanced sequences and diffusion images add no significant statistical role in the diagnosis of bone marrow edema. Inflammatory laboratory parameters were increased in higher grades of sacroiliitis. HLA-B27, although not specific to inflammatory sacroiliitis, increases in higher grades of sacroiliitis.

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Association of Genetic Marker HLA-B27 with Spondyloarthritis In A Tertiary Care Centre In South India

Cited by 3 publications

References 22 publications

Frequent Cases of Spondylarthritis and Hereditary Propensity (HLA-B27) in the Same Family Name Relatives from the Keda Region of Ajara, Georgia

Frequent Cases of Spondylarthritis and Hereditary Propensity (HLA-B27) in the Same Family Name Relatives from the Keda Region of Ajara, Georgia

Correlation of Interleukin-17 and 23 Inflammatory Markers with Genetically Transmitted Spondyloarthritis Patients at a Tertiary Care Facility, South India

To study magnetic resonance imaging findings and inflammatory markers in inflammatory sacroiliitis

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