Association of Genetic Polymorphisms at 1q22 but not 10q23 with Gastric Cancer in a Southern Chinese Population

Abstract

Objective: Data from a recent genome-wide association studiesy of gastric cancer (GC) and oesophageal squamous cell carcinoma in Chinese living in the Taihang Mountains of north-central China suggest that 1q22 and 10q23 are susceptibility-associated regions for GC. However, this has not been confirmed in southern Chinese populations. The aim of this study was to investigate whether these polymorphisms at 1q22 and 10q23 are associated with the risk of GC in a southern Chinese population. Methods: We selected seven top significant associated single nucleotide polymorphisms (SNPs) at 1q22 and 10q23 and conducted a population-based casecontrol study in a southern Chinese population. Genotypes were determined using MassARRAYTM system (Sequenome, San Diego, CA). Results: Two SNPs at 1q22, rs4072037 and rs4460629, were significantly associated with a reduced risk of GC, best fitting the dominant genetic model. Logistic regression models adjusted for age and sex showed that rs4072037 AG and GG (OR=0.64, P=0.017, compared with AA) and rs4460629 CT and TT (OR=0.54, P=0.0016, compared with TT) significantly reduced the risk of GC. However, no significant results for the five SNPs at 10q23 were obtained in this study. Conclusion: These outcomes indicate that 1q22 is associated with GC susceptibility in this southern Chinese population, while an association for the locus at 10q23 was not confirmed.

Helicobacter pylori Infection Synergizes with Three Inflammation-Related Genetic Variants in the GWASs to Increase Risk of Gastric Cancer in a Chinese Population

“…pylori serology in an independent case–control study of 335 GC cases and 334 controls in a Chinese population. The results were consistent with the association in the three GWASs [7–9] and other recently published independent replication studies in China [19–21]. However, these studies all lacked data about H.…”

Two novel polymorphisms inPLCE1are associated with the susceptibility to esophageal squamous cell carcinoma in Chinese population

“…Whereas for gastric cancer and ESCC, no significant association was found in some researches. 23,24 The Genome-wide association studies conducted by Abnet et al found that the nonsynonymous variants rs3765524 of PLCE1 gene was associated with increased risk of ESCC. 14 Nevertheless the present study showed no association between rs3765524 and ESCC risk among Chinese Han population.…”

MUC1 rs4072037 Polymorphism is Associated with Decreased Risk of Gastric Cancer: A Meta-analysis

“…Risk allele A at the rs4072037 polymorphism has been reported to be associated with a decreased physiological function of MUC1 (33). Recently, many studies (4,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)21) have reported the association between MUC1 rs4072037 polymorphism and GC susceptibility, but their findings were conflicting. And these studies may have had inadequate statistical power due to relatively small samples, clinical heterogeneity and different ethnic populations.…”