Association of genetic polymorphisms in the <i>Matrix Gla Protein (MGP)</i> gene with coronary artery disease and serum mgp levels

Karslı-Çeppioğlu, Seher; Yazar, Selma; Keskin, Yaşar; Karaca, Mujdegul Zayifoglu; Ne, Luleci; Yurdun, Türkan

doi:10.2478/bjmg-2019-0020

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…Hladiny MGP v séru pacientů, u kterých je na koronárních tepnách přítomná kalcifikace, vykazují souvislost s polymorfismy rs4326 a rs1800802 (cit. 29,30 ). Bylo popsáno, že tepny postižené aterosklerózou obsahovaly v intimě uc-MGP a u Monckebergovy mediokalcinózy byl uc-MGP v médii.…”

Section: Vztah Hladiny Mgp K Metabolismu Cévunclassified

Biochemical Significance of Matrix Gla Protein and Its Potential Use as a Marker in Clinical Biochemistry

Barna,

Čepová,

Dunovská

et al. 2024

Chem. Listy

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The aim of this work was to present an overview on the biochemical significance of the matrix γ‑carboxyglutamate (Gla) protein (MGP). According to the literature, the MGP is associated with vascular, bone, and kidney metabolisms, as well asvitamin K levels. The relationship of MGP to Keutel's syndrome, Pseudoxanthoma elasticum, colitis, and dental calculus is described. The information published so far suggests that MGP protein levels could have potential as a biochemical marker in these serious diseases.

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Section: Vztah Hladiny Mgp K Metabolismu Cévunclassified

Biochemical Significance of Matrix Gla Protein and Its Potential Use as a Marker in Clinical Biochemistry

Barna,

Čepová,

Dunovská

et al. 2024

Chem. Listy

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Matrix Gla protein polymorphism rs1800802 is associated with atheroma plaque progression and with cardiovascular events in a chronic kidney disease cohort

Cambray,

Bermúdez-López,

Garcia-Carrasco

et al. 2023

Clinical Kidney Journal

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Background Chronic kidney disease (CKD) is associated with increased atherosclerotic burden and higher risk for cardiovascular events (CVE). Atherosclerosis has a significant genetic component and, in CKD, it is influenced by mineral metabolism alterations. Therefore, genetic modifications of mineral metabolism–related proteins could affect atherosclerosis in CKD patients. In the present study we investigated the role of single nucleotide polymorphisms (SNPs) of the matrix gamma-carboxy glutamic acid protein (MGP) on atherosclerosis progression and CVE in a CKD cohort. Methods A total of 2187 CKD patients from the Observatorio Nacional de Aterosclerosis en Nefrologia (NEFRONA) study were genotyped for SNPs present in the matrix gamma-carboxy glutamic acid (Gla) protein (MGP) gene. Atheromatosis was detected by vascular ultrasound. Progression of atheromatosis, defined as an increase in territories with plaque, was assessed after 24 months. Patients were followed for 48 months for CVE. Association of SNPs with plaque progression was assessed by logistic regression and their capacity to predict CVE by Cox regression. Results Three SNPs of the MGP gene were analyzed. No association of the rs4236 or the rs1800801 SNPs was detected with any of the outcomes. However, patients homozygotes for the minor allele of the rs1800802 SNP showed higher adjusted risk for plaque progression [odds ratio 2.3 (95% confidence interval 1.06–4.9)] and higher risk of suffering a CVE [hazard ratio 2.16 (95% confidence interval 1.13–4.12)] compared with the rest of genotypes. No association of the SNP with total or dp-ucMGP levels was found in a subsample. Conclusions The rs1800802 polymorphism of MGP is associated with plaque progression and CVE in CKD patients.

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Vitamin K₂—a neglected player in cardiovascular health: a narrative review

et al. 2021

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Vitamin K2 serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the cardiovascular system are mediated through activation of the anti-calcific protein known as matrix Gla protein. In its inactive form, this protein is associated with various markers of cardiovascular disease including increased arterial stiffness, vascular and valvular calcification, insulin resistance and heart failure indices which ultimately increase cardiovascular mortality. Supplementation of vitamin K2 has been strongly associated with improved cardiovascular outcomes through its modification of systemic calcification and arterial stiffness. Although its direct effects on delaying the progression of vascular and valvular calcification is currently the subject of multiple randomised clinical trials, prior reports suggest potential improved survival among cardiac patients with vitamin K2 supplementation. Strengthened by its affordability and Food and Drug Adminstration (FDA)-proven safety, vitamin K2 supplementation is a viable and promising option to improve cardiovascular outcomes.

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Association of genetic polymorphisms in the Matrix Gla Protein (MGP) gene with coronary artery disease and serum mgp levels

Cited by 3 publications

References 25 publications

Biochemical Significance of Matrix Gla Protein and Its Potential Use as a Marker in Clinical Biochemistry

Biochemical Significance of Matrix Gla Protein and Its Potential Use as a Marker in Clinical Biochemistry

Matrix Gla protein polymorphism rs1800802 is associated with atheroma plaque progression and with cardiovascular events in a chronic kidney disease cohort

Vitamin K₂—a neglected player in cardiovascular health: a narrative review

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Association of genetic polymorphisms in the Matrix Gla Protein (MGP) gene with coronary artery disease and serum mgp levels

Cited by 3 publications

References 25 publications

Biochemical Significance of Matrix Gla Protein and Its Potential Use as a Marker in Clinical Biochemistry

Biochemical Significance of Matrix Gla Protein and Its Potential Use as a Marker in Clinical Biochemistry

Matrix Gla protein polymorphism rs1800802 is associated with atheroma plaque progression and with cardiovascular events in a chronic kidney disease cohort

Vitamin K2—a neglected player in cardiovascular health: a narrative review

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Vitamin K₂—a neglected player in cardiovascular health: a narrative review