Association of hematological indices with prediabetes: A cross-sectional study

Abstract

BackgroundPrediabetes is a condition that occurs when blood glucose levels are higher than normal, but not high enough to be classified as diabetes. Prediabetic people have an increased risk of developing type 2 diabetes and cardiovascular disease. Moreover Hyperglycemia has multiple effects on the hematological parameters.ObjectiveTo examine the association between hematological indices and anthropometric measurement, with prediabetes.MethodsThis cross-sectional study was conducted on 125 diabetics and 259 prediabetics in the 20–70 age range. They were selected by a convenience sampling method at the Taban Diabetes Center in 2015. An oral glucose tolerance test was performed for each participant who had never been diagnosed with diabetes. Participants were characterized as having prediabetes or diabetes according to American Diabetes Association criteria. The hematologic parameters were measured by using Sysmex-KX 21N analyzers. Data were analyzed by IBM-SPSS version 22 using independent-samples t-test, Mann-Whitney U test, and Pearson’s correlation coefficient at p<0.05.ResultsThere was significant difference in mean corpuscular hemoglobin concentration (MCVH) (33.81±0.92 g/dL vs. 34.06±1.05 g/dL) between prediabetes patients and diabetes. There was not a statistically significant difference in the prediabetics’ hematological parameters, compared with the diabetics. In the prediabetic group, only the mean corpuscular hemoglobin concentration was found to be negatively correlated with diastolic blood pressure (p=0.013) and FBS (p=0.026).ConclusionHematological indices are important markers for the assessment of variations in size, number, and maturity of different blood cells. Hematological indices could be utile indicators of vascular complication and glycemic control in type 2 DM patients. Thus, they are important for the evaluation and early management of patients with per diabetes.

Basic Coagulation Profiles and Platelet Parameters Among Adult Type 1 and Type 2 Diabetes Patients at Dessie Referral Hospital, Northeast Ethiopia: Comparative Cross-Sectional Study

“…A similar finding was reported in Iran which found that no statistically significant correlation between FBG and platelet count in DM patients. 43 The contrary finding was reported in China which found a significant positive correlation between FBG and platelet count, PDW, and MPV in T2DM patients, 40 and in Nigeria reported a significant positive correlation between FBG and platelet count in T1DM. 38 The reason for this variation might be due to variation in the population, variation sample size, and variation in automated hematology analyzer.…”

Relationship between hematological parameters and glycemic control in type 2 diabetes mellitus patients

“…Blood is classified as a connective tissue, with cellular elements suspended in plasma. Elevated blood glucose level in T2DM contributes to disturbance ofblood cells and its indices ( 3 ). Good glycemic control is the main recommendation in the prevention of the development of diabetic complications.…”

Lycopene improves on basic hematological and immunological parameters in diabetes mellitus

“…No changes in the mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration (Table 1), demonstrating the safety of Lycopene at varying concentrations on blood. In diabetes, these hematological indices are often high [8], thus the use of Lycopene in integrative medicine would help lessen side effects and toxicities associated with conventional therapies in diabetes.…”

“…Hematological indices i.e. mean corpuscular hemoglobin concentration (MCVH) has been shown to be higher in diabetic patients and the mean corpuscular hemoglobin concentration negatively correlated with blood pressure demonstrating the importance of hematological indices in diabetes [8]. In severe diabetic human patients, anemia has been associated with low hemoglobin (Hb) levels [9] demonstrating its importance as a clinical marker in this regard.…”