Association of herpesviruses in the aqueous humor of patients with serpiginous choroiditis: a polymerase chain reaction-based study

Kannian, Priya; Madhavan, H. N.; Reiser, Bibiana J.; Biswas, Jyothirmay; Rambhatla, Saptagirish; Narayana, K.; Rao, Narsing A.

doi:10.1076/ocii.10.4.253.15585

Cited by 48 publications

(19 citation statements)

References 12 publications

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“…17,72,73 Similarly, serpiginous choroiditis is described in association with tuberculosis, varicella zoster virus, and herpes simplex virus. 74 Interestingly, antiviral treatments do not improve the clinical outcomes of patients with serpiginous choroiditis, suggesting that infections may trigger disease onset but are not the underlying cause of retinal damage. 75 Other pathogenic mechanisms have been proposed for WDS.…”

Section: Pathogenesis Of White Dot Syndromementioning

confidence: 99%

OCT and Fundus Autofluorescence Enhances Visualization of White Dot Syndromes

Wong¹,

Nivison‐Smith²,

Assaad

et al. 2015

Optometry and Vision Science

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Section: Pathogenesis Of White Dot Syndromementioning

confidence: 99%

OCT and Fundus Autofluorescence Enhances Visualization of White Dot Syndromes

Wong¹,

Nivison‐Smith²,

Assaad

et al. 2015

Optometry and Vision Science

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“…Association of herpes viruses in the aqueous humor of patients with serpiginous choroiditis have been studied based on PCR results by Priya et al 24 In our patients, antiviral drugs were given in cases that were PCR positive for herpes viruses from the aqueous aspirate, along with systemic steroids. We suggest anterior chamber tap for PCR for viruses in those patients who have cells in the anterior chamber.…”

Section: Serpiginous Choroiditismentioning

confidence: 99%

Clinical Profile, Treatment, and Visual Outcome of Serpiginous Choroiditis

Abrez

Biswas

Sridharan

2007

Ocular Immunology and Inflammation

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The purpose of this study was to report the clinical profile and management of patients with serpiginous choroiditis in a tertiary care referral center in India. In a retrospective cohort study, 107 eyes of 70 patients with serpiginous choroiditis seen between January 1995 and December 2002 were analyzed. Systemic steroids and immunosuppressives were the mainstay of therapy. Antituberculous and antiviral drugs were used in selected cases. There was male preponderance (7:3). Age at presentation ranged from 11 years to 52 years (mean 30.3 +/- 9 years); 52.9% had bilateral involvement. Vision improved or maintained in 86% eyes and deteriorated in 15 eyes (14%). The main cause of decrease of vision was macular involvement. Improvement in vision and resolution of lesions in patients with serpiginous choroiditis can occur with combination therapy of systemic steroids and immunosuppressive agents. Serial examination at regular intervals is needed to monitor the disease progression, recurrences, and involvement of the other eye.

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“…4e7 Although several infectious or noninfectious causes of MSC have been recognized, 8 laboratory evidence for Mycobacterium tuberculosis or other causative agents is lacking. There are isolated reports of patients with serpiginous choroiditis with evidence of M. tuberculosis, 2,9,10 herpes, 11 or toxoplasmosis 12 that has been shown using molecular techniques such as polymerase chain reaction (PCR).…”

mentioning

confidence: 99%