Association of High Serum Homocysteine Levels and Severe Chronic Venous Disease

Gao, Hongxia; Xu, Huimin; Zhang, Jiantao; Premaratne, Shyamal; Su, Xudong; Zhang, Wenpei; Wang, Shengquan; Sun, Lei; Yao, Jie; Hao, Bin; Yang, Tao

doi:10.1016/j.avsg.2020.12.036

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…Furthermore, the increase in the formation of free radicals and reactive oxygen species (ROS), the majority of which are unpaired electron species that target important biomolecules in their search for electrons, is triggered by the accumulation of homocysteine in the body. Although these ROS have certain positive functions, mostly as signaling molecules, their negative consequences are more common when they are created in large amounts (Gao et al, 2021). Our findings demonstrate a redox imbalance in rats fed with a vitamin B12deficit diet, advancing our understanding of the mechanism of oxidative damage in this condition.…”

Section: Discussionmentioning

confidence: 64%

CONSUMPTION OF Hibiscus sabdariffa DRIED CALYX ETHANOL EXTRACT IMPROVED REDOX IMBALANCE AND GLUCOSE PLASMA IN VITAMIN B12 RESTRICTION DIET IN RATS

Ujianti

Sianipar

Prijanti

et al. 2022

MABJ

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This study aimed to evaluate the effect of Hibiscus sabdariffa L. dried calyx ethanolic (HSE) extract on the redox imbalance and glucose plasma of vitamin B12 restriction Sprague-Dawley rats. The rat was fed a Vitamin B12 Restriction Diet for 16 weeks and treated with HSE as the treatment group. One group was fed a restriction diet not treated with HSE as a positive control group, and another was fed a control chow diet not treated with HSE as a negative control group. Vitamin B12, MDA, SOD activity enzyme, and glucose levels were evaluated in this study. The extract had a significant antioxidant capacity in terms of reducing the production of free radical scavenging activity. The HSE can repair the skewed redox imbalance and oxidative damage generated by a vitamin B12-deficient diet in the rat liver. The result of fasting glucose plasma levels, in 16 weeks showed both significantly different in all groups. In Sprague-Dawley rats with vitamin B12 restriction treated with HSE, a decrease in the glucose plasma in week sixteen was observed, together with a reduction of hepatic redox imbalance. Treatment with HSE protected hepatocytes from oxidative damage caused by vitamin B12 deficiency.

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Section: Discussionmentioning

confidence: 64%

CONSUMPTION OF Hibiscus sabdariffa DRIED CALYX ETHANOL EXTRACT IMPROVED REDOX IMBALANCE AND GLUCOSE PLASMA IN VITAMIN B12 RESTRICTION DIET IN RATS

Ujianti

Sianipar

Prijanti

et al. 2022

MABJ

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“…Excessive consumption of these diets high in saturated fats and sugars lead to obesity, metabolic syndrome, and impairment of cardiac functions; however, the underlying mechanisms are not fully understood [ 16 ]. TMAO is a primary gut microbiota-dependent metabolite of specific dietary nutrients and known as a key contributor to cardiovascular disease pathogenesis.…”

Section: High Fat-high Sugar Dietmentioning

confidence: 99%

“…While hepcidin released from the liver could be sequestering iron systemically, the hepcidin from dendritic cells could potentially be working through a means of nutritional immunity by keeping a tight control on local iron and its availability to pathogenic bacteria to promote intestinal homeostasis by starving them of their food source. This ultimately allows tissue repair in the lumen at a much more localized level, analogous to a “first responder” to the area of inflammation directly [ 16 ]. Embracing their role, dendritic cells in the gut also function to sample luminal content to monitor for pathogens and enhance effector responses in response to infection and disease.…”

Section: Dendritic Cell Derived Hepcidinmentioning

confidence: 99%

The Prevention of Inflammation and the Maintenance of Iron and Hepcidin Homeostasis in the Gut, Liver, and Brain Pathologies

Kania

Sotelo

et al. 2023

JAD

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The human gut microbiome consists of a variety of microorganisms that inhabit the intestinal tract. This flora has recently been shown to play an important role in human disease. The crosstalk between the gut and brain axis has been investigated through hepcidin, derived from both hepatocytes and dendritic cells. Hepcidin could potentially play an anti-inflammatory role in the process of gut dysbiosis through a means of either a localized approach of nutritional immunity, or a systemic approach. Like hepcidin, mBDNF and IL-6 are part of the gut-brain axis: gut microbiota affects their levels of expression, and this relationship is thought to play a role in cognitive function and decline, which could ultimately lead to a number of neurodegenerative diseases such as Alzheimer’s disease. This review will focus on the interplay between gut dysbiosis and the crosstalk between the gut, liver, and brain and how this is mediated by hepcidin through different mechanisms including the vagus nerve and several different biomolecules. This overview will also focus on the gut microbiota-induced dysbiotic state on a systemic level, and how gut dysbiosis can contribute to beginnings and the progression of Alzheimer’s disease and neuroinflammation.

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The characteristics of arterial risk factors and ankle-brachial index in patients with lower extremity chronic venous diseases: results from the BEST study

JIANG,

LIU,

LIU

et al. 2024

Int Angiol

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Association of High Serum Homocysteine Levels and Severe Chronic Venous Disease

Cited by 3 publications

References 19 publications

CONSUMPTION OF Hibiscus sabdariffa DRIED CALYX ETHANOL EXTRACT IMPROVED REDOX IMBALANCE AND GLUCOSE PLASMA IN VITAMIN B12 RESTRICTION DIET IN RATS

CONSUMPTION OF Hibiscus sabdariffa DRIED CALYX ETHANOL EXTRACT IMPROVED REDOX IMBALANCE AND GLUCOSE PLASMA IN VITAMIN B12 RESTRICTION DIET IN RATS

The Prevention of Inflammation and the Maintenance of Iron and Hepcidin Homeostasis in the Gut, Liver, and Brain Pathologies

The characteristics of arterial risk factors and ankle-brachial index in patients with lower extremity chronic venous diseases: results from the BEST study

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