Association of human leukocyte antigen class II alleles with response to immunosuppressive therapy in Korean aplastic anemia patients

Diagnosis of acquired aplastic anemia

“…29 In a recent study on 37 Korean patients with severe AA, responders to immunosuppressive treatment had a significantly higher HLA-DR15 and lower DR4 frequency compared with nonresponders. 30 The response rates in the best (DR15( þ )/DR4( À )), intermediate, and poor response groups (DR15( À )/DR4( þ )) were 88.9%, 38.5% and 0%, respectively (P ¼ 0.00001). At the allelic level, DRB1*1501 and closely linked DQB1*0602 were associated with a good response and DRB1*0405 and closely linked DQB1*0401 with a poor response to IST.…”

Correlation analysis of severe aplastic anemia immunosuppressive therapy and human leukocyte antigen alleles in pediatric patients

“…However, Song et al detected no association between DR4 or HLA-DR4-Ala74β and AA susceptibility (10). Furthermore, Song et al (11) investigated the association between IST efficacy and HLA-II in 37 cases of SAA in Korean patients, and the results suggested that although DR4 was not associated with AA susceptibility, DR4 was associated with a poor response to IST. In particular, the IST reactivities in DRB1*04:05 + , DR4-Ala74β + and HLA-DR4 + patients were significantly reduced compared with those of DR4 -patients (5.9 vs. 60.0%).…”

“…AA has also been reported to be associated with HLA (10). Previous studies that have investigated the correlation between HLA and AA have observed that certain specific HLA alleles or genes are genetic factors that mediate the immunopathogenesis of AA (11), and are associated with IST efficacy, since Chapuis et al (12) initially proposed the correlation of HLA-DR2 with AA in 1985. Studies have demonstrated that HLA-DRB1*15 (a HLA-DR2 subtype) is among the genotypes that predisposes a child to develop AA (2)(3)(4).…”

“…Studies have demonstrated that HLA-DRB1*15 (a HLA-DR2 subtype) is among the genotypes that predisposes a child to develop AA (2)(3)(4). In addition, it has been shown that HLA-DRB1*15 is associated with the immunosuppressive therapy of children with AA (11,13,14); children who were positive for HLA-DRB1*15 exhibited a good response to the simple cyclosporine A (CsA) treatment and enhanced immunosuppressive therapy. However, previous studies concerning the association of HLA with AA in different provinces of China have yielded inconsistent results (15,16), and IST-related studies of HLA are limited.…”

Correlations between HLA-A, HLA-B and HLA-DRB1 Allele Polymorphisms and Childhood Susceptibility to Acquired Aplastic Anemia

“…Researchers from Turkey, South Korea, Pakistan and China found that DRB1*15 is one of the susceptibility genes of childhood AA [8,9,10,11]. Further studies revealed that DRB1*1501 is a susceptibility gene of AA [11,12,13,14,15,16]. The expression of DRB1*1501 and DRB1*1502 among AA patients is notably higher than in the general population [13].…”