2023
DOI: 10.1001/jamanetworkopen.2023.0034
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Association of Hypertensive Disorders of Pregnancy With Future Cardiovascular Disease

Abstract: ImportanceHypertensive disorders in pregnancy (HDPs) are major causes of maternal and fetal morbidity and are observationally associated with future maternal risk of cardiovascular disease. However, observational results may be subject to residual confounding and bias.ObjectiveTo investigate the association of HDPs with multiple cardiovascular diseases.Design, Setting, and ParticipantsA genome-wide genetic association study using mendelian randomization (MR) was performed from February 16 to March 4, 2022. Pri… Show more

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Cited by 40 publications
(38 citation statements)
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“…19 In addition, a recent MR analysis, which only included women for genetic associations with HDPs, showed genetically proxied HDPs to be related to a higher risk of coronary artery disease or ischaemic stroke. 11 Furthermore, genetically proxied pre-eclampsia and gestational hypertension were associated with a higher risk of coronary artery disease but not with risk of ischaemic stroke. 11 This is not in line with the results of the present study, in which we did find a significantly higher risk for ischaemic stroke for genetically proxied pre-eclampsia/eclampsia in women.…”
Section: Discussionmentioning
confidence: 98%
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“…19 In addition, a recent MR analysis, which only included women for genetic associations with HDPs, showed genetically proxied HDPs to be related to a higher risk of coronary artery disease or ischaemic stroke. 11 Furthermore, genetically proxied pre-eclampsia and gestational hypertension were associated with a higher risk of coronary artery disease but not with risk of ischaemic stroke. 11 This is not in line with the results of the present study, in which we did find a significantly higher risk for ischaemic stroke for genetically proxied pre-eclampsia/eclampsia in women.…”
Section: Discussionmentioning
confidence: 98%
“…11 Furthermore, genetically proxied pre-eclampsia and gestational hypertension were associated with a higher risk of coronary artery disease but not with risk of ischaemic stroke. 11 This is not in line with the results of the present study, in which we did find a significantly higher risk for ischaemic stroke for genetically proxied pre-eclampsia/eclampsia in women.…”
Section: Findings From Previous Studiesmentioning
confidence: 98%
See 3 more Smart Citations