Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants

Kroll, Caroline; Mastroeni, Silmara S. B. S.; Veugelers, Paul J.; Mastroeni, Marco Fábio

doi:10.1002/ajhb.22893

Cited by 10 publications

(4 citation statements)

References 44 publications

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“…However, the findings of studies regarding the risk allele are controversial. Some authors suggest that the G-allele is the risk allele for developing excess body weight [26,27,43], while others indicate the A-allele to be associated with excess body weight [23,28,44]. These controversial results are not well elucidated in the literature.…”

Section: Discussionmentioning

confidence: 99%

Associations of ADIPOQ and LEP Gene Variants with Energy Intake: A Systematic Review

et al. 2019

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This systematic review aims to evaluate the association of adiponectin (ADIPOQ) and leptin (LEP) gene variants with energy intake. Cross-sectional, cohort, and case–control studies that reported an association of leptin and/or adiponectin gene variants with energy intake were included in this review. Human studies without any age restrictions were considered eligible. Detailed individual search strategies were developed for each of the following bibliographic databases: Cochrane, Latin American and Caribbean Center on Health Sciences Information (LILACS), PubMed/MEDLINE, Scopus, and Web of Science. Risk of bias assessment was adapted from the Downs and Black scale and was used to evaluate the methodology of the included studies. Seven studies with a pooled population of 2343 subjects were included. The LEP and ADIPOQ gene variants studied were LEP-rs2167270 (k = 1), LEP-rs7799039 (k = 5), ADIPOQ-rs2241766 (k = 2), ADIPOQ-rs17300539 (k = 1), and ADIPOQ marker D3S1262 (k = 1). Two of the seven studies reviewed demonstrated a positive association between the LEP-rs7799039 polymorphism and energy intake. Two other studies—one involving a marker of the ADIPOQ gene and one examining the ADIPOQ-rs17300539 polymorphism—also reported associations with energy intake. More research is needed to further elucidate the contributions of genetic variants to energy metabolism.

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Section: Discussionmentioning

confidence: 99%

Associations of ADIPOQ and LEP Gene Variants with Energy Intake: A Systematic Review

et al. 2019

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“…An in-depth description of the PREDI Study has been published previously (28)(29)(30)(31) . Briefly, all women over 18 years of age who gave birth to a full-term singleton (between 37 and 42 weeks of gestation) admitted to a public maternity hospital in Joinville (Brazil) from 14 January to 16 February 2012 were invited to participate.…”

Section: Study Design and Populationmentioning

confidence: 99%

“…The genotyping method has been described previously (28) . Approximately 10 ml of blood were collected from the newborn at the time of delivery by aspiration of the umbilical vein close to the placenta up to 10 min after clamping to prevent coagulation (39) .…”

Section: Genotypingmentioning

confidence: 99%

Adiponectin and leptin gene variants and their effects on body weight trajectories in children from birth to 6 years of age: the PREDI Study

Kroll¹,

Farias²,

Kac³

et al. 2020

Br J Nutr

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Excess body weight confers a high risk to human health. Body weight variation between subjects can be partially explained by genetic differences. The aim of this study was to investigate the association of genetic variants in the ADIPOQ (rs2241766) and LEP (rs7799039) genes with body weight trajectories in children from birth to six years of age. This was a prospective cohort (PREDI Study). Socioeconomic, biological and anthropometric data were collected at four time points: at birth in the maternity unit; 1-2 years old, 4-5 years old, and 6 years old at the participant’s home. Genotyping was performed by PCR-RFLP. Poisson regression and linear mixed-effect regression models were used to address the association of ADIPOQ and LEP genotypes with BMI. Excessive body weight at pre-pregnancy (β=0.339, p=0.01) and excessive gestational weight gain (β=0.51, p<0.001) were associated with children’s BMI trajectory from birth to six years. The ADIPOQ-rs2241766 TG or GG genotype was associated with a higher risk of excess body weight in the first six years of life (both sexes: RR=1.25, 95%CI: 1.01-1.56; female: RR=1.67, 95%CI: 1.20-2.31). BMI increased over the years according to the presence of the TG or GG genotype (β=0.01, 95%CI: 0.01-0.02), particularly in females (β=0.02, 95%CI: 0.01-0.04). The ADIPOQ-rs2241766 TG and GG genotypes increased the risk of excess body weight in children from birth to six years of age and had a positive effect on body weight trajectories in girls. The LEP-rs7799039 genetic variant was not associated with body weight trajectory in children.

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“…The genotyping method has been described previously (Kroll et al, ). Blood samples were collected by nurses in the pre‐delivery room or immediately after delivery at the maternity unit and transferred to an FTA CloneSaver card (GE Healthcare, UK).…”

Section: Methodsmentioning

confidence: 99%

Association between FTO gene polymorphism and excess body weight in women from before to after pregnancy: A cohort study

Kroll

França

Mastroeni

2018

American J Hum Biol

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Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants

Abstract: This study showed that the GG genotype of the LEP polymorphism rs7799039 is a risk factor for LGA infants. The exact role and mechanism of action of the GG genotype of this polymorphism in weight status control remain to be elucidated, and more studies are needed.

Cited by 10 publications

References 44 publications

Associations of ADIPOQ and LEP Gene Variants with Energy Intake: A Systematic Review

Associations of ADIPOQ and LEP Gene Variants with Energy Intake: A Systematic Review

Adiponectin and leptin gene variants and their effects on body weight trajectories in children from birth to 6 years of age: the PREDI Study

Association between FTO gene polymorphism and excess body weight in women from before to after pregnancy: A cohort study

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