Association of VDR polymorphisms (Taq I and Bsm I) with prostate cancer: a new meta-analysis

Abstract

ObjectiveProstate cancer is a malignant tumour that poses a serious risk to human health. Epidemiological studies suggest that it may be associated with vitamin D receptor gene (VDR) polymorphisms. Previous work investigated potential risks between Taq I (rs731236) and Bsm I (rs1544410) VDR polymorphisms with prostate cancer in humans; however, results are inconsistent.MethodsWe conducted a meta-analysis to retrieve genetic association analyses of rs731236 and rs1544410 polymorphisms with prostate cancer from studies published between 2006–2016. Pooled odds ratios with 95% confidence intervals were used to assess genetic associations, and heterogeneity was assessed by Q and I2statistics.ResultsOur findings suggest a significant association between rs731236 and prostate cancer risk in Asians and African Americans, but rs1544410 was not associated with prostate cancer under three genetic models.ConclusionFuture studies including larger sample sizes and the analysis of gene functions are needed to help develop prostate cancer treatment.

Vitamin D deficiency accelerates ageing and age‐related diseases: a novel hypothesis

“…In the case of cancer, polymorphisms of the vitamin D receptor (VDR) have been linked to the onset of prostate cancer (Liu et al . ). The fact that the ability of the skin to make vitamin D declines as ageing progresses is one reason why cognition tends to decline during ageing (MacLaughlin & Holick, ; Kennel et al .…”

DHPLC Elution Patterns of VDR PCR Products Can Predict Prostate Cancer Susceptibility in African American Men

“…A previous publication has reported that the Taq I (rs731236) polymorphism affects VDR transcriptional activity and mRNA stability, thus altering the abundance of VDR protein, and in turn affecting vitamin D levels (39). Liu S. and colleagues (40) have conducted a meta-analysis to retrieve genetic association analyses of rs731236 and rs1544410 polymorphisms with PCa from studies published between 2006 and 2016. Their findings suggest a significant association between rs731236 and PCa risk in Asians and African Americans, but rs1544410 was not associated with PCa under three genetic models.…”

Vitamin D receptorTaqI polymorphism and the risk of prostate cancer: a meta-analysis

“…However, these results have been disputable [ 20 – 22 ]. Previous meta-analyses were reported by Yin et al in 2009, Fei et al in 2016 and Liu et al in 2017 [ 10 , 23 , 24 ], in which the number of included studies was 23, 27 and 8, respectively. However, some new data was reported, which is not consistent with the results of the former three studies [ 17 , 25 – 27 ].…”

“…Taq I polymorphism (rs731236) is one of the most widely-studied SNPs. It is a synonymous mutation located in exon 9 of VDR gene [ 10 ]. This mutation could reduce the mRNA stability and therefore decrease the mRNA levels of VDR gene [ 11 ].…”

“…The difference might be due to under-power for individual study. Moreover, previous meta-analyses [ 10 , 23 , 24 ] seem to be outdated since new data appeared [ 17 , 25 – 27 ]. Therefore, we conduct this meta-analysis to get more accurate results.…”