Association of IL-6 polymorphisms with gastric cancer risk: Evidences from a meta-analysis

Wang, Junli; He, Wenjun; Liu, Jinxin; Li, Nong; Wei, Ye‐Sheng; Yang, Fenglian

doi:10.1016/j.cyto.2012.03.032

Cited by 26 publications

(4 citation statements)

References 37 publications

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“…A further meta-analysis that included 39 case–control studies, showed statistically significant associations between the IL1RN*22 genotype and both intestinal-type and diffuse-type GC, showing ORs of 1.83 and 1.72, respectively (78). Further examples of polymorphisms in pro-inflammatory cytokines/chemokines that play an essential role promoting inflammation in the context of gastrointestinal carcinogenesis are IL-4 ( IL4 -590C/T and -168T/C) (79), IL-6 ( IL6 -174 G/C) (80–82), IL-8 ( IL8 -251 A/T, +396 T/G, and +781 C/T) (79, 83), IL-10 ( IL10 -1082 A/G, −819 C/T, and −592 C/A) (84–86), IL-12 ( IL12A -701 C/A, −798 T/A, +277 G/A, and −504 T/G) (87), IL-17 ( IL17 -197 G/A and +7488 T/C) (79), IL-18 ( IL18 -137 G/C) (88), and TNF-α ( TNFA −238 G/A, −308 G/A, and −857 C/T) (89). In addition to this, a recent comprehensive review on this topic recommended the investigation of other polymorphisms in IL1B (3954 C/T and −1473G/C), IL4 (–168T/C), IL6 (572 G/C and 597 G/A), and IL17 (+7488A/G and −197G/A), given their potential relevance in GC (79).…”

Section: Inflammation In Gastric Cancermentioning

confidence: 99%

Pattern-Recognition Receptors and Gastric Cancer

2014

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Chronic inflammation has been associated with an increased risk of several human malignancies, a classic example being gastric adenocarcinoma (GC). Development of GC is known to result from infection of the gastric mucosa by Helicobacter pylori, which initially induces acute inflammation and, in a subset of patients, progresses over time to chronic inflammation, gastric atrophy, intestinal metaplasia, dysplasia, and finally intestinal-type GC. Germ-line encoded receptors known as pattern-recognition receptors (PRRs) are critical for generating mature pro-inflammatory cytokines that are crucial for both Th1 and Th2 responses. Given that H. pylori is initially targeted by PRRs, it is conceivable that dysfunction within genes of this arm of the immune system could modulate the host response against H. pylori infection, and subsequently influence the emergence of GC. Current evidence suggests that Toll-like receptors (TLRs) (TLR2, TLR3, TLR4, TLR5, and TLR9), nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) (NOD1, NOD2, and NLRP3), a C-type lectin receptor (DC-SIGN), and retinoic acid-inducible gene (RIG)-I-like receptors (RIG-I and MDA-5), are involved in both the recognition of H. pylori and gastric carcinogenesis. In addition, polymorphisms in genes involved in the TLR (TLR1, TLR2, TLR4, TLR5, TLR9, and CD14) and NLR (NOD1, NOD2, NLRP3, NLRP12, NLRX1, CASP1, ASC, and CARD8) signaling pathways have been shown to modulate the risk of H. pylori infection, gastric precancerous lesions, and/or GC. Further, the modulation of PRRs has been suggested to suppress H. pylori-induced inflammation and enhance GC cell apoptosis, highlighting their potential relevance in GC therapeutics. In this review, we present current advances in our understanding of the role of the TLR and NLR signaling pathways in the pathogenesis of GC, address the involvement of other recently identified PRRs in GC, and discuss the potential implications of PRRs in GC immunotherapy.

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Section: Inflammation In Gastric Cancermentioning

confidence: 99%

Pattern-Recognition Receptors and Gastric Cancer

2014

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“…Concretely, Yu et al 35 addressed that there was no association between a functional polymorphism IL-6 −174G>C and breast cancer risk, regardless of the distinct ethnicities. Likewise, Wang et al 36 showed that IL-6 −174G>C, −592G>C, and −597G>A polymorphisms were not associated with gastric cancer risk; subsequent subgroup analysis also did not explore any significant association in Asian or Caucasian population. Besides, no associations were found between IL-6 −174G>C and lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Association between interleukin-6 polymorphisms and urinary system cancer risk: evidence from a meta-analysis

Zhang¹,

Zhang²,

Zhou³

et al. 2016

OTT

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BackgroundInterleukin-6 (IL-6) is a multifunctional proinflammatory cytokine involved in cancer initiation and progression. Numerous studies have investigated the associations between IL-6 polymorphisms (IL-6 −174G>C, −592G>C, −597G>A) and risk of urinary system cancers, including prostate cancer, bladder cancer, and renal cell cancer. However, conclusions from these studies were controversial. Thus, we conducted the current meta-analysis to obtain the comprehensive profile regarding the association between IL-6 polymorphisms and urinary system cancer risk.MethodsAccording to inclusion and exclusion criteria, the associations of IL-6 polymorphisms with urinary system cancer were searched from database and analyzed using STATA 12.0 statistical software. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.ResultsA total of 20 previous publications consisting of 15,033 cases and 17,655 controls were involved in this meta-analysis. Significant association was observed in overall population regarding IL-6 −592G>C polymorphisms (G vs C: OR =0.1.30, 95% CI =1.13−2.52; GG vs CC: OR =1.81, 95% CI =1.31−2.52; GG vs GC + CC: OR =1.33, 95% CI =1.02−1.75; GG + GC vs CC: OR =1.41, 95% CI =1.09−1.83). In the stratified analyses by ethnicity, the significant associations were found among Asian (GG vs CC: OR =1.89, 95% CI =1.34−2.66; GG + GC vs CC: OR =1.43, 95% CI =1.09−1.87) and Black population (GC vs CC: OR =0.20, 95% CI =0.05−0.82) rather than Caucasian men. Likewise, there were noticeable associations in almost all the other subanalyses such as cancer types, control sources, genotyped methods, and sample sizes. However, no significant associations were identified between any of IL-6 −174G>C polymorphisms with urinary system cancer, except for Asian population (G vs C: OR =0.81, 95% CI =0.70−0.95; GG vs CC: OR =0.51, 95% CI =0.35−0.74; GC vs CC: OR =0.49, 95% CI =0.33−0.72; GG + GC vs CC: OR =0.50, 95% CI =0.35−0.72; respectively). In addition, no significant associations were detected between IL-6 −597G>A polymorphism and urinary system cancer, regardless of whole or subgroups.ConclusionThis meta-analysis presents a relatively comprehensive view of the associations between IL-6 polymorphism and urinary system cancer risk to explore the carcinogenic mechanisms, which will help shed light on the clinical diagnosis and therapy for urinary system cancer. However, further detailed studies are needed to verify our conclusion.

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“…25 IL6 (rs1800797) also play a role in the pathogenesis of several types of cancer, there were found a significant association between IL 6(rs1800797) variant with breast cancer 26 , non-hodgkin's lymphoma 27 , but not gastric cancer. 28 Association of distribution of IL6 (rs1800797) variant with several diseases are known to vary according to race or ethnicity. In the meta-analysis by Wang et al (2019) showed IL6 polymorphism (rs1800797) may be associated with an increased risk of liver diseases in the non-Asian population.…”

Section: Cont Table 3 Genotypes and Alleles Frequency Of Il6 (Rs1800797) In Healthy Control Among Different Populationsmentioning

confidence: 99%

The Interleukin-6 (rs1800797) Variant in Healthy Individuals at Medan City, North Sumatera Province

Sari¹,

Syarifah²,

Daulay³

et al. 2021

IJFMT

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The Interleukin-6/IL6 (rs1800797) variant play a role in several diseases pathogenesis. The frequency genotype of IL6 (rs1800797) varied based on different race, ethnicity, and underlying character in population. This study aimed to assess the frequency of genotype and allele of IL6 (rs1800797) in healthy individuals at Medan city, North Sumatera Province Province and this study can be used as a reference in determining of several diseases for further studies. Genotyping of IL6 (rs1800797) in the promoter region using polymerase chain reaction and restriction fragment length polymorphism method, analysis using FokI restriction enzyme. This study showed that the genotype frequency of GG, GA, and AA were 95.8 %, 4.2 %, and 0 %, respectively. The allele frequency of G and A were 97.9 % and 2.1 %, respectively. The results indicated that the homozygous wild-type (GG) of IL6 (rs1800797) was higher than the heterozygous mutant (GA) and there was absent of homozygous mutant (AA) in this population. The frequency of G allele also higher than A mutant allele.

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Association of IL-6 polymorphisms with gastric cancer risk: Evidences from a meta-analysis

Cited by 26 publications

References 37 publications

Pattern-Recognition Receptors and Gastric Cancer

Pattern-Recognition Receptors and Gastric Cancer

Association between interleukin-6 polymorphisms and urinary system cancer risk: evidence from a meta-analysis

The Interleukin-6 (rs1800797) Variant in Healthy Individuals at Medan City, North Sumatera Province

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