Association of inflammatory markers with angiographic severity and extent of coronary artery disease

Drakopoulou, Maria; Toutouzas, Konstantinos; Stefanadi, Elli; Tsiamis, Eleftherios; Tousoulis, Dimitris; Stefanadis, Christodoulos

doi:10.1016/j.atherosclerosis.2009.01.041

Cited by 80 publications

(59 citation statements)

References 45 publications

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“…NLR is a CBC index, which shows inflammatory status. In the light of recent data and studies, WBC count and index as NLR are independent predictors of short and term mortality in patients with AMI (7,10,(14)(15)(16)(17). NLR is an independent predictor of cardiac mortality in stable CAD patients (9) and predictor of mortality in patients undergoing percutaneous coronary intervention (6).…”

Section: Discussionmentioning

confidence: 99%

“…Inflammation might explain the higher NLR values in patients with complex CAD. It has been reported that elevated inflammatory markers (14,15), RDW (22) and WBC counts (5,23) are associated with the extent and severity of CAD. However, we did not measure other inflammatory markers in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…The low-grade inflammation with (2, 14, 15) inflammatory marker and oxygen radicals released by aggregated and activated neutrophils can be shown in circulation especially in coronary sinus (14)(15)(16). NLR is a CBC index, which shows inflammatory status.…”

Section: Discussionmentioning

confidence: 99%

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Relation of neutrophil -to- lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study

Sönmez

Ertaş²,

Bacaksız³

et al. 2013

Anadolu Kardiyol Derg

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Objective: The neutrophil -to-lymphocyte ratio (NLR) is a new predictor for cardiovascular risk and mortality. The SYNTAX score is an angiographic tool used in grading the complexity of coronary artery disease (CAD). However, its relation with CAD severity and complexity is not yet known. We hypothesized that NLR would be associated with a greater complexity of CAD as assessed using the SYNTAX score. Methods: This cross-sectional observational study included 106 patients who had undergone coronary angiography for stable angina pectoris and 69 patients who had normal coronary angiogram. Baseline NLR was measured by dividing neutrophil count to lymphocyte count. The patients were classified two groups as CAD (-) (n=69) and CAD (+) (n=106), then patients in CAD (+) group were divided into 3 groups according to SYNTAX scores (SYNTAX score 1-22, 23-32, >32) as pointed in European Society of Cardiology (ESC) revascularization guideline. Statistical analysis was performed using the Mann-Whitney U and Kruskal-Wallis tests, and multiple logistic regression analysis was used to identify the independent predictors of complexity of CAD-SYNTAX score. Results: Patients with CAD had a significantly higher value of NLR [1.6 median (1.2-3.3 IQR) vs. 2.3 median (1.8-3.0 IQR) p<0.001]. The group with high SYNTAX scores (>32) more frequently had diabetes mellitus (DM), hypercholesterolemia (HL), were of older age, and also had significantly elevated NLR values [2.4 (1.3-2.6), 2.6 (2.3-3.9), 2.0 (1.5-2.6) p=0.006]. In univariate analysis, age, DM, HL, creatinine, neutrophil count and NLR were predictors of high SYNTAX score. In the multiple logistic regression analysis, only NLR [odds ratio (OR)=2.1, 95% confidence interval (CI) 1.2-3.8, p=0.09], was identified as independent predictor of a high SYNTAX score. Conclusion: NLR is a strong clinical laboratory value that is associated with presence and complexity of CAD. (Anadolu Kardiyol Derg 2013; 13: 662-7) Key words: Neutrophil -to-lymphocyte ratio, complexity, coronary artery disease, regression analysis, sensitivity, specificity Original Investigation Özgün Araşt›rma 662ÖZET Amaç: Nötrofil lenfosit oranı (NLO) kardiovasküler risk ve mortalite için yeni bir öngördürücüdür. SYNTAX skoru koroner arter hastalığı (KAH) karmaşıklığını derecelendirmede anjiyografik bir yöntemdir. NLO ile KAH varlığı ve karmaşıklığı arasındaki ilişki henüz ortaya konmamıştır. Biz SYNTAX skorunu kullanarak NLO ile KAH varlığı ve karmaşıklığı arasında daha güçlü bir ilişki olabileceği tezini öne sürdük. Yöntemler: Bu enine kesit gözlemsel çalışmaya 106 koroner anjiyografisi yapılmış stabil angina pectoris hastası ve 69 normal koronere sahip hastalar dahil edildi. Bazal NLO nötrofil sayısının lenfosit sayısına oranı olarak hesaplandı. Hastalar KAH olan ve olmayan şeklinde iki gruba ayrıldı. KAH grubu SYNTAX skoruna göre Avrupa Kardiyoloji Cemiyeti miyokardiyal girişim kılavuzuna dayanarak 3 gruba ayrıldı (23)(24)(25)(26)(27)(28)(29)(30)(31)(32) >32). İstatistiksel analiz Mann-Whitney U ve Kruskal-Wal...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Relation of neutrophil -to- lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study

Sönmez

Ertaş²,

Bacaksız³

et al. 2013

Anadolu Kardiyol Derg

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“…Most noticeable is the greater macrophage and T lymphocyte infiltration into the atherosclerotic plaque, as well as larger necrotic cores compared with nondiabetic specimens 22. With increased severity comes an associated increased risk of coronary artery disease, myocardial infarction, stroke, or peripheral artery disease 23, 24. Atherosclerotic cardiovascular disease (CVD) remains the principal cause of death and disability in people with DM, especially in people with T2D 25.…”

Section: Diabetes and Cardiovascular Diseasementioning

confidence: 99%

Recent novel approaches to limit oxidative stress and inflammation in diabetic complications

et al. 2018

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Diabetes is considered a major burden on the healthcare system of Western and non‐Western societies with the disease reaching epidemic proportions globally. Diabetic patients are highly susceptible to developing micro‐ and macrovascular complications, which contribute significantly to morbidity and mortality rates. Over the past decade, a plethora of research has demonstrated that oxidative stress and inflammation are intricately linked and significant drivers of these diabetic complications. Thus, the focus now has been towards specific mechanism‐based strategies that can target both oxidative stress and inflammatory pathways to improve the outcome of disease burden. This review will focus on the mechanisms that drive these diabetic complications and the feasibility of emerging new therapies to combat oxidative stress and inflammation in the diabetic milieu.

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“…Inflammation plus oxidative stress has been implicated in the hemorheology and pathophysiology of many cardiovascular, brain-vascular, peripheral artery and other non-hematological and hematological chronic diseases [10,[42][43][44][45].…”

Section: Introductionmentioning

confidence: 99%

Medical significance of simultaneous application of red blood cell distribution width (RDW) and neopterin as diagnostic/prognostic biomarkers in clinical practice

Zvetkova

Fuchs²

2017

Pteridines

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In our individual and collaborative studies, we have played a part in pioneering investigations on the usefulness of biomarkers -red blood cell distribution width (RDW) and neopterin. This mini review includes historical data on the topic and is related to the first contributions in this field, as well as to the possibilities for further improvement and simultaneous application of RDW and neopterin measurements in the prevention, prognosis and treatment of a great number of socially important disease conditions (arterial, cardiovascular, brain vascular, peripheral artery diseases, inflammations, autoimmune states, cancers and leukemias, addictions, etc.). When comparing the results obtained with the immunobiochemical biomarker neopterin with RDW, they are reported to be very similar as independent predictors of the same pathological states in the human body although their biomedical origins are very different. Both the parameters were until now successfully, but only separately used in medical practice. The combined use of these two biomarkers can shed some more light on their interrelationships and provide some clues as to how the interaction between immune system activation and red blood cells biology are intertwined.

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Association of inflammatory markers with angiographic severity and extent of coronary artery disease

Cited by 80 publications

References 45 publications

Relation of neutrophil -to- lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study

Relation of neutrophil -to- lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study

Recent novel approaches to limit oxidative stress and inflammation in diabetic complications

Medical significance of simultaneous application of red blood cell distribution width (RDW) and neopterin as diagnostic/prognostic biomarkers in clinical practice

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