Association of influenza virus infection and inflammatory cytokines with acute myocardial infarction

Guan, Xue; Yang, Wei; Sun, Xi-juan; Wang, Lanfeng; Ma, Ben-Jiang; Li, Hongyuan; Zhou, Jin

doi:10.1007/s00011-012-0449-3

Cited by 59 publications

(59 citation statements)

References 37 publications

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“…However, other studies have shown an association among influenza, influenza vaccination and AMI. In a recent case-control study in China, serological evidence of influenza was found to significantly predict recent AMI 16. Other observational studies have found influenza vaccination to be protective against AMI, recurrent AMI and cardiac death 15 21.…”

Section: Discussionmentioning

confidence: 92%

Ischaemic heart disease, influenza and influenza vaccination: a prospective case control study

MacIntyre

Heywood

Kovoor

et al. 2013

Heart

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BackgroundAbundant, indirect epidemiological evidence indicates that influenza contributes to all-cause mortality and cardiovascular hospitalisations with studies showing increases in acute myocardial infarction (AMI) and death during the influenza season.ObjectiveTo investigate whether influenza is a significant and unrecognised underlying precipitant of AMI.DesignCase-control study.SettingTertiary referral hospital in Sydney, Australia, during 2008 to 2010.PatientsCases were inpatients with AMI and controls were outpatients without AMI at a hospital in Sydney, Australia.Main outcome measuresPrimary outcome was laboratory evidence of influenza. Secondary outcome was baseline self-reported acute respiratory tract infection.ResultsOf 559 participants, 34/275 (12.4%) cases and 19/284 (6.7%) controls had influenza (OR 1.97, 95% CI 1.09 to 3.54); half were vaccinated. None were recognised as having influenza during their clinical encounter. After adjustment, influenza infection was no longer a significant predictor of recent AMI. However, influenza vaccination was significantly protective (OR 0.55, 95% CI 0.35 to 0.85), with a vaccine effectiveness of 45% (95% CI 15% to 65%).ConclusionsRecent influenza infection was an unrecognised comorbidity in almost 10% of hospital patients. Influenza did not predict AMI, but vaccination was significantly protective but underused. The potential population health impact of influenza vaccination, particularly in the age group 50–64 years, who are at risk for AMI but not targeted for vaccination, should be further explored. Our data should inform vaccination policy and cardiologists should be aware of missed opportunities to vaccinate individuals with ischaemic heart disease against influenza.

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Section: Discussionmentioning

confidence: 92%

Ischaemic heart disease, influenza and influenza vaccination: a prospective case control study

MacIntyre

Heywood

Kovoor

et al. 2013

Heart

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“…18 The mechanism through which IV infection leads to AMI is unclear. To explore the mechanism of atherosclerosis, Guan et al 19 conducted a case–control study to examine inflammatory cytokines to assess the association between previous IV infection and AMI, and they found that inflammatory cytokines may participate in the development of atherosclerosis and trigger the occurrence of AMI. A self-controlled case series analysis indicated that influenza infection can act as a trigger for AMI.…”

Section: Discussionmentioning

confidence: 99%

A Matched Influenza Vaccine Strain Was Effective in Reducing the Risk of Acute Myocardial Infarction in Elderly Persons

et al. 2016

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The aim of this study was to explore whether matched or mismatched strains of influenza vaccines (IVs) are beneficial at reducing the risk of acute myocardial infarction (AMI) in elderly persons.Data were obtained from the Longitudinal Health Database 2005 (LHID 2005) which is maintained by the National Health Insurance Research Institute in Taiwan. The analytical data included individuals who were vaccinated with mismatched vaccines during the October 2007 to December 2007 season and individuals vaccinated with matched strains during the October 2008 to December 2008 season. All participants were 65 years of age and older. In this analysis, individuals were considered to be exposed if their records showed that they were vaccinated against influenza, and they were considered to be nonexposed if they were not vaccinated during these seasons. A Cox hazard model was used to estimate AMI hazard ratio.This study enrolled 93,051 exposed and 109,007 unexposed individuals. The AMI hazards ratios (HRs) for the men and women exposed to mismatched vaccine (in 2007) were 0.990 (95% confidence interval [CI], 0.745–1.316) and 1.102 (95% CI: 0.803–1.513), respectively. Men exposed to matched vaccines (in 2008) had significant HRs (HR: 0.681; 95% CI: 0.509–0.912) while the HRs in the women were barely significant (HR: 0.737; 95% CI: 0.527–1.029).AMI risk could be particularly reduced in men if the IV matches well with the circulating strains in elderly people 65 years of age and older.

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“…2), which may destabilize atherosclerotic plaques, leading to coronary artery occlusion (13). There are some reports to support the concept that systemic inflammation itself alters the probability of a cardiovascular event (6,7,14). On the other hand, the present patient exhibited components of cardio-renal syndrome (CRS) types 4 and 5 as the cause of multiple organ failure, as he had both chronic kidney disease due to diabetic nephropathy and systemic disorder-induced severe heart failure and diabetes mellitus (15).…”

Section: Discussionmentioning

confidence: 99%

A Fatal Case of Acute Myocardial Infarction following the Improvement of Influenza A(H1N1)pdm2009-related Acute Myocarditis

et al. 2014

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A 52-year-old Indian man was hospitalized due to dyspnea and a high fever caused by influenza A(H1N1) pdm2009. Elevated cardiac enzymes, a chest X-ray showing bilateral infiltrative shadows, cardiomegaly and pleural effusion and echocardiography indicating diffuse hypokinesis of the left ventricle suggested cardiac failure due to acute myocarditis. Owing to the administration of combined modality therapy, including steroids and intravenous γ-globulin, the patient's clinical symptoms of influenza completely resolved. However, he suddenly complained of epigastric pain due to acute myocardial infarction and died. This report is an educational case, the results of which suggest that greater attention should be paid to the potential for myocardial infarction even after an influenza virus infection is found to improve.

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Association of influenza virus infection and inflammatory cytokines with acute myocardial infarction

Abstract: Objective

Cited by 59 publications

References 37 publications

Ischaemic heart disease, influenza and influenza vaccination: a prospective case control study

Ischaemic heart disease, influenza and influenza vaccination: a prospective case control study

A Matched Influenza Vaccine Strain Was Effective in Reducing the Risk of Acute Myocardial Infarction in Elderly Persons

A Fatal Case of Acute Myocardial Infarction following the Improvement of Influenza A(H1N1)pdm2009-related Acute Myocarditis

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