Association of KIBRA rs17070145 polymorphism and episodic memory in individuals with severe TBI

Posttraumatic Brain Injury Cognitive Performance Is Moderated by Variation Within ANKK1 and DRD2 Genes

“…This study was not powered to examine genotypic associations by race in post-TBI cognitive outcomes, and future studies are needed to examine more racially-diverse populations. While this study is limited by its overall sample size, it is one of the larger studies examining genetic factors in cognitive recovery post-TBI, similar to our previous studies 72 . Due to the loss to follow-up in this study, future studies will need to validate these findings in larger groups at 12 months, and to validate the observed genetic effects for consistency across recovery.…”

Acute CSF interleukin-6 trajectories after TBI: Associations with neuroinflammation, polytrauma, and outcome

“…Many studies have shown that genetic variation is associated with outcomes and conditions following TBI (Hoh et al, 2010;Weaver et al, 2012;Wagner et al, 2012;Garringer et al, 2013;Diamond et al, 2014;Failla et al, 2014). Of note, an IL-6 polymorphism (À174 G/C) has been reported as associated with mortality after severe TBI (Dalla Libera et al, 2011) and the development of Alzheimer's disease in non-TBI populations (Qi et al, 2012).…”

KIBRA gene variants are associated with synchronization within the default-mode and executive control networks

“…Although 7/9 independent cohorts did not reveal any significant differences between genotypes (Nacmias et al, 2008;Papassotiropoulos et al, 2006;Preuschhof et al, 2010;Schaper et al, 2008;Wagner et al, 2012;Zhang et al, 2009a), one study on European Americans reported poorer performance in executive function in T-allele carriers, an effect that was modulated by recent tobacco use (Zhang et al, 2009a). Moreover, although there was no main effect of the KIBRA polymorphism on executive function, one study revealed that T-allele carriers with arterial hypertension performed significantly poorer on tests of executive function than non-T-allele carriers (Wersching et al, 2011).…”

“…However, a beneficial effect of the T-allele was not shown in 7/22 cohorts (Bates et al, 2009;Burgess et al, 2011;Jacobsen et al, 2009;Need et al, 2008;Wersching et al, 2011). Moreover, two previous studies even reported a deleterious effect of the T-allele on episodic memory (Nacmias et al, 2008;Wagner et al, 2012). Although the inconsistencies across studies may be related to the differences in age, ethnicity, disease status, and memory tests used in these previous studies, a meta-analysis of 8000 subjects suggested that the KIBRA polymorphism only plays a modest role in episodic memory (Burgess et al, 2011).…”

“…Most of these studies showed a beneficial effect of the T-allele on episodic memory (Almeida et al, 2008;Bates et al, 2009;Kauppi et al, 2011;Papassotiropoulos et al, 2006;Preuschhof et al, 2010;Schaper et al, 2008;Vassos et al, 2010;Yasuda et al, 2010), although non-significant (Bates et al, 2009;Burgess et al, 2011;Jacobsen et al, 2009;Need et al, 2008;Wersching et al, 2011) and deleterious effects (Nacmias et al, 2008;Wagner et al, 2012) have also been demonstrated. As for executive functions (Table S2), a non-significant association has commonly been reported (Nacmias et al, 2008;Papassotiropoulos et al, 2006;Preuschhof et al, 2010;Schaper et al, 2008;Wagner et al, 2012;Zhang et al, 2009a); however, two studies found a significant association (Wersching et al, 2011;Zhang et al, 2009a). The KIBRA C-allele homozygote is frequently associated with an increased risk for AD (Burgess et al, 2011;Corneveaux et al, 2010), although negative and contradictory findings (Rodriguez-Rodriguez et al, 2009) have also been reported (Table S3).…”