Introduction: Drop in levels of physical activity is associated with occurrence of diseases that can lead to disability and death. Objective: To determine the level of physical activity and the presence of depression, as well their relationship with body mass index in patients. Methods: In the family medicine clinic, within the pilot study, in the first half of 2010 year, through the Interview with 141 patients, the following questionnaires were completed: International Physical Activity Questionnaire (IPAQ) and Patient Health Questionnaire (PHQ-9). The data were processed according to the instructions for questionnaires for PHQ-9 and IPAQ. The patients underwent measurements of blood pressure, sugar and cholesterol levels in blood and body mass index (BMI). Results: Of the total 141 respondents, more than half (61.70%) were aged 25 -54 years, median 44th years (±14.3). Nearly 3/4 of respondents (73.76%) had the PHQ-9 score value of ≤4, and slightly more than 1/4 of the respondents had the PHQ-9 score value of ≥5. The largest number of respondents (51.80%) over the week had moderate physical activity, with statistically significant difference (χ 2 = 566.7, p <0.01) compared to those who had vigorous (16.30%) and low (32.00%) physical activity. Over 2/3 of respondents (67.60%) with the PHQ-9 score ≥ 5 had high BMI and were obese and engaged in moderate physical activity (48.00%). The median sitting in minutes in the last week was greater in those with PHQ-9 score ≥5 (545 minutes) compared to those with PHQ-9 score ≤ 4. Discussion: Moderate physical activity is important in preventing depression and stress. Conclusion: Obligation of the family doctor is to promote physical activity in all age groups as an important factor for improving health and preventing disease.