Association of Leptin Gene Polymorphism with Growth Rate in Lohi Sheep

Saleem, Ali Haider; Javed, Khalid; Babar, Masroor Ellahi; Hussain, Tanveer; Ali, Asad; Ali, Amir R.; Ahmad, Nisar; Farooq, Muhammad; Dawood, Muhammad

doi:10.17582/journal.pjz/2018.50.3.1029.1033

Cited by 9 publications

(10 citation statements)

References 11 publications

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“…It also detected two mutation sites (G447C and T498C) in GHRL-2, one mutation site (C105T) in GHRL-6, these were slightly different with previous research conclusion. Ali et al (2018) reported that the "W" heterozygous genotype of Leptin Gene showed higher daily gain than other genotypes in Lohi Sheep. we will further study the function of GHRL gene, in particular, make clear that whether 3 SNP loci (T498C, G447C, C105T) were associated with goat growth and development performance or not.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism Analysis of GHRL Gene in Goat

Bai¹

2019

PJZ

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Section: Discussionmentioning

confidence: 99%

Polymorphism Analysis of GHRL Gene in Goat

Bai¹

2019

PJZ

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“…Generally, the BC genotype and B allele were improved growth traits than other genotypes and alleles in Makooei sheep and the estimated effects suggest that most of the impact of LEP is realized after weaning. Further the research of Saleem et al (2018)…”

Section: Assosiation Leptin Gene Polymorphism With Growthmentioning

confidence: 96%

Single nucleiotide polymorphisms on exon 3 of leptin gene and their association with growth in Padjadjaran sheep

Rahmat

Hilmia

Bandiati

2020

J. Indonesian Trop. Anim. Agric.

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The diversity of leptin genes in cattle has an impact to the physiological function of the leptin hormone as anti-obesity. This study was aimed to determine polymorphisms of the Leptin gene based on Single Nucleotide Polymorphism on exon 3rd and their effect to body weight, of Padjadjaran sheep. DNA samples were obtained from the blood of 26 Padjadjaran rams 1 years. Data of leptin gene diversity were analyzed from the results of PCR product sequencing by Sanger Methode of 696 bp leptin exon 3. Point mutations (SNPs) on nucleotide sequence were analyzed using Bioedit and MEGA 7 Program. Growth parameters which were measured i.e. monthly body weight gain until one year of age. The association of leptin gene polymorphism with body weight was find out by unpaired T test. The results showed there were SNPs in Leptin gene in exon 3 of Padjadjaran sheep, namely g.170 G> A and g. 332.A> G. Both of these mutations are non-synonymous mutations because there were altered amino acids from Arginine to Glutamine. Genotyping was done based on the two mutations above and got two alleles G and A, each of which has an allele frequency of 0.75 and 0.25, with the frequency of each genotype, AG and GG was 0.5. There was not association between SNPs on leptin gene with body weight from birth to 12 months of age.

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“…Leptin hormone, encoded by LEP gene, has significant importance in regulating various functions of growth, process and growth traits such as weaning weight, six-months body weight and nine-month body weight, etc. In addition to its functions, Saleem et al (2018) stated this role in regulation of feed intake, metabolic process and meat quality traits in cattle, buffalo, goat and sheep.…”

Section: Gene Expression Analysismentioning

confidence: 99%

Evaluation of Growth Performance, Blood Metabolites and Gene Expression Analysis in Egyptian Sheep Breeds, in Relation to Age

Ashour¹,

Gad²,

Fayed³

et al. 2020

jwpr

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The growth performance of lambs attributes the economic viability of animals. Faster growth allows lambs to reach maturity in early age. Therefore, the aim of this study was to compare growth performance, blood metabolites and expression of IGF-1, GH, and Leptin genes in three different Egyptian sheep breeds across age. Thirty Egyptian sheep males from three breeds (Ossimi, Rahmani and Barki) were divided into three ages categorize (7-9, 10-12, and 13-16 months). The results showed that there was a significant increase in sheep's live body weights toward advanced ages till the second age category for all breeds, the highest values of linear body measurements were observed in Ossimi breed. There was a non-significant inverse effect of advanced age on blood glucose and total lipids levels in all sheep breeds. There wasn't any significant effect of interaction between age and breed on plasma total protein concentrations. According to age categories, Barki breed showed a significant up-regulation of GH compared to the Ossimi breed in 7-9 months age category. However, Barki breed showed a significant downregulation of IGF-1compared to the Ossimi breed in 7-9 months. Meanwhile, Leptin expression showed significant differences in Ossimi breed between 10-12 months age category and two other age categories. We concluded that measuring of physical body measurements, blood metabolites and GH, IGF-1 and Leptin genes in early ages is a good and accurate indicator for growth performance in Egyptian sheep breeds.

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Association of Leptin Gene Polymorphism with Growth Rate in Lohi Sheep

Cited by 9 publications

References 11 publications

Polymorphism Analysis of GHRL Gene in Goat

Polymorphism Analysis of GHRL Gene in Goat

Single nucleiotide polymorphisms on exon 3 of leptin gene and their association with growth in Padjadjaran sheep

Evaluation of Growth Performance, Blood Metabolites and Gene Expression Analysis in Egyptian Sheep Breeds, in Relation to Age

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