Association of long non‐coding RNA MEG3 polymorphisms with oral squamous cell carcinoma risk

Hou, Yunwen; Zhang, Bo; Miao, Limin; Ji, Yefeng; Ye, Yu; Zhu, Lucheng; Ma, Hongxia; Yuan, Hua

doi:10.1111/odi.13103

Cited by 23 publications

(11 citation statements)

References 25 publications

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“…For example, in clinical therapy, surgical resection is an effective treatment for localized tumors, but the disease could still exhibit potential regional or distant metastasis, or high resistance toward conventional chemotherapy and radiotherapy. Therefore, researchers have focused on the potential molecular biologi-cal mechanisms of cancer development, such as genetic biomarkers which can be used as prognostic factors for cancer patients [4].…”

Section: Introductionmentioning

confidence: 99%

Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis

Dong¹,

Gao

et al. 2020

Disease Markers

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Purpose. Long noncoding RNAs (lncRNAs) have been widely studied, and single nucleotide polymorphisms (SNPs) in lncRNAs are considered to be genetic factors that influence cancer susceptibility. The lncRNA GAS5, MEG3, and PCAT-1 polymorphisms are shown to be possibly associated with cancer risk. The aim of this meta-analysis was to systematically evaluate this association. Methods. Studies were selected from PubMed, Web of Science, Embase, Google Scholar, Cochrane Library, the Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biomedical Literature Database (CBM) through inclusion and exclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the random-effects model or fixed-effects model to assess the association between lncRNA polymorphisms and cancer susceptibility. Metaregression and publication bias analyses were also conducted. All analyses were performed using the Stata 12.0 software. Results. Sixteen articles (covering 13750 cases and 17194 controls) were included in this meta-analysis. A significant association between SNP rs145204276 and gastric cancer risk was observed (del vs. ins: OR = 0:79, 95%CI = 0:72-0:86; del/del vs. ins/ins+del/ins: OR = 0:74, 95%CI = 0:59-0:91; del/ins vs. ins/ins: OR = 0:84, 95%CI = 0:67-1:05). For rs16901904, a decreased cancer risk was observed in three genetic models (C vs. T: OR = 0:79, 95%CI = 0:70-0:90; CC vs. CT+TT: OR = 0:49, 95%CI = 0:37-0:65; CC vs. TT: OR = 0:49, 95%CI = 0:37-0:66). No statistical significance was found in the metaregression analysis. For all of the included SNPs, no publication bias was found in all genotype models. Conclusions. The rs145204276 SNP in lncRNA GAS5 is likely to be associated with gastric cancer risk, whereas the rs16901904 SNP in lncRNA PCAT-1 bears association with a decreased cancer risk.

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Section: Introductionmentioning

confidence: 99%

Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis

Dong¹,

Gao

et al. 2020

Disease Markers

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“…Previous evidences showed that MEG3 was highly expressed in normal tissues such as brain, pituitary, placenta and adrenal gland, and its transcripts can be detected in several human organs including ovary, testes, spleen, pancreas, liver, and mammary gland [7]. However, the expression of MEG3 was lower in various human tumors compared with that in normal human tissues, including breast cancer [24]. MEG3…”

Section: Discussionmentioning

confidence: 99%

“…It is also reported that SNPs in MEG3 gene have an in uence on cancer risk. For example, Hou et al observed a statistically signi cant increased risk between MEG3 rs11160608 and oral squamous cell carcinoma (OSCC) [24]. And Bayarmaa et al found MEG3 polymorphisms were related to the chemotherapy response and toxicity of paclitaxel and cisplatin in breast cancer patients [32].…”

Section: Discussionmentioning

confidence: 99%

LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study

Zheng

Wang

et al. 2020

Preprint

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Abstract Background: LncRNA MEG3 expressed abnormally in various cancers including breast cancer, but no studies reported the correlation between MEG3 SNPs and breast cancer susceptibility among Chinese women. Methods: This study is aimed to explore the association between three SNPs of MEG3 (rs3087918, rs7158663, rs11160608) and breast cancer. The study is a population-based case-control study including 434 breast cancer patients and 700 healthy controls. Genotyping was performed using Sequenom MassArray technique. Function prediction of rs3087918 were based on RNAfold and lncRNASNP2 databases. Results: Pooled analysis indicated that rs3087918 was related to a decreased risk of breast cancer [GG vs. TT: OR(95%) = 0.67(0.45-0.99), P = 0.042; GG vs. TT + TG: OR(95%) = 0.69(0.48-0.99), P = 0.046], especially for women aged <=49 [GG vs. TT: OR(95%) = 0.40(0.22-0.73), P = 0.02]. Comparison between case groups showed genotype GG and TG/GG of rs3087918 were associated with her-2 receptor expression [GG vs. TT: OR(95%) = 2.37(1.24-4.63), P = 0.010; TG + GG vs. TT: OR(95%) = 1.50(1.01-2.24), P = 0.045]. We didn’t find statistical significance for rs11160608, rs7158663 and breast cancer. Structure prediction based on RNAfold found rs3087918 may influence the secondary structure of MEG3. The results based on lncRNASNP2 indicated that rs3087918 may gain the targets of hsa-miR-1203 to MEG3, while loss the target of hsa-miR-139-3p and hsa-miR-5091 to MEG3. Conclusions: MEG3 rs3087918 was associated with a decreased risk of breast cancer. MEG3 haplotype TCG may increase the risk of breast cancer.

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“…As the most common type of genetic Previous evidences showed that MEG3 was highly expressed in normal tissues such as brain, pituitary, placenta and adrenal gland, and its transcripts can be detected in several human organs including ovary, testes, spleen, pancreas, liver, and mammary gland [4]. However, the expression of MEG3 was lower in various human tumors compared with that in normal human tissues, including breast cancer [15]. MEG3 was recognized as a tumor suppressor deponed on recent researches.…”

Section: Discussionmentioning

confidence: 99%

LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study

Zheng

Wang

et al. 2020

Preprint

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Background LncRNA MEG3 expressed abnormally in various cancers including breast cancer, but no studies reported the correlation between MEG3 SNPs and breast cancer susceptibility. Methods This study is aimed to explore the association between three SNPs of MEG3 (rs3087918, rs7158663, rs11160608) and breast cancer. The study is a population-based case-control study including 434 breast cancer patients and 700 healthy controls. Genotyping was performed using Sequence MassArray technique. Function prediction of rs3087918 were based on RNAfold and lncRNASNP2 databases. Results Pooled analysis indicated that rs3087918 was related to a decreased risk of breast cancer (GG vs. TT: P = 0.042; GG vs. TT + TG: P = 0.046), especially for women aged 49 and above (GG vs. TT: P = 0.02). Comparison between case groups showed genotype GG and TG/GG of rs3087918 were correlated with her-2 receptor expression (GG vs. TT: P = 0.010; TG + GG vs. TT: P = 0.045). We didn’t find statistical significance for rs11160608, rs7158663 and breast cancer. Structure prediction based on RNAfold found rs3087918 may influence the secondary structure of MEG3. The results based on lncRNASNP2 indicated rs3087918 may gain the targets of hsa-miR-1203 to MEG3, while loss the target of hsa-miR-139-3p and hsa-miR-5091 to MEG3. Conclusions MEG3 rs3087918 was associated with a decreased risk of breast cancer. MEG3 haplotype TCG (SNP sequence: rs3087918, rs11160608, rs7158663) may increase the risk of breast cancer. And the protest effect of rs3087918 on breast cancer may owe to its effect on the structure and function of MEG3.

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Association of long non‐coding RNA MEG3 polymorphisms with oral squamous cell carcinoma risk

Cited by 23 publications

References 25 publications

Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis

Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis

LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study

LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study

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