Association of macrovascular complications of type 2 diabetes mellitus with serum magnesium levels

Agrawal, Pushpa; Arora, Sarika; Singh, Bhawna; Manamalli, A.; Dolia, Pragna B.

doi:10.1016/j.dsx.2010.12.003

Cited by 33 publications

(27 citation statements)

References 17 publications

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“…We did not find any significant difference for either serum or urinary Mg between uncomplicated T2D patients and T2D patients with either DN and DR or DPN. An early study also reported that there was no significant difference for serum Mg among three groups [10]: uncomplicated T2D ( n = 30, serum Mg: 1.67±0.084), T2D with coronary atherosclerosis ( n = 30, 1.60±0.072), and with peripheral vascular disease ( n = 30, 1.71±0.085). However, there were also reports that showed the low level of serum Mg in T2D with food ulcer [20] and retinopathy [30] compared to uncomplicated T2D patients.…”

Section: Discussionmentioning

confidence: 94%

“…For instance, Sharma et al have demonstrated the during of diabetes with serum Mg were inversely related [30]. In addition, mean serum Mg level was found to be lower among those with known diabetes than those with new diabetes, which also suggests the length of diabetes may affect the serum Mg [10].…”

Section: Discussionmentioning

confidence: 99%

“…Mg, one of the important components of many foods such as grains, nuts, and green leafy vegetables, is the fourth most abundant cation in our body and plays a key role in many fundamental biological processes, including energy metabolism. Mg has received considerable attention for its potential in improving insulin sensitivity and preventing diabetes and its cardiovascular complications [10]–[13]. However, results are inconsistent among the studies [14], [15].…”

Section: Introductionmentioning

confidence: 99%

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Associations of Serum and Urinary Magnesium with the Pre-Diabetes, Diabetes and Diabetic Complications in the Chinese Northeast Population

Yao

et al. 2013

PLoS ONE

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The effect of magnesium (Mg) deficiency on the prevalence of diabetes and diabetic complications has received a great attention. The present study investigated the association of Mg level in the serum or urine of the patients, lived in the Northeast areas of China, with either pre-diabetes or diabetes with and without complications. From January 2010 to October 2011, patients with type 1 diabetes (T1D, n = 25), type 2 diabetes (T2D, n = 137), impaired fasting glucose (IFG, n = 12) or impaired glucose tolerance (IGT, n = 15), and age/gender matched control (n = 50) were enrolled in the First Hospital of Jilin University. In T2D group, there were 24, 34, and 50 patients with nephropathy, retinopathy or peripheral neuropathy. Serum Mg levels in the patients with IGT, IFG, T2D, and T1D were significantly lower than that of control. The urinary Mg levels were significantly increased only in T2D and T1D patients compared to control. There was no difference for these two changes among T2D with and without complications; In addition, there was a significantly positive correlation of serum Mg levels with serum Ca levels only in T2D patients, and also a significantly positive correlation of urinary Mg levels with urinary Ca levels in control, IGT patients, and T2D patients. Simvastatin treatment in T2D patients selectively reduced serum Ca levels and urinary Mg levels. These results suggest that the potential impact of Mg deficiency on metabolic syndrome, diabetes and diabetic complications needs to be received special attention.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations of Serum and Urinary Magnesium with the Pre-Diabetes, Diabetes and Diabetic Complications in the Chinese Northeast Population

Yao

et al. 2013

PLoS ONE

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“…, the effect of Mg supplementation on CVD risk factors was not evaluated. Various observational studies also suggest a beneficial role of Mg in reducing the risk of CVD .…”

Section: Introductionmentioning

confidence: 99%

Effect of magnesium supplementation on type 2 diabetes associated cardiovascular risk factors: a systematic review and meta‐analysis

Verma

Garg

2017

J Human Nutrition Diet

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“…Diabetes and its complications make up a major public health problem all over the world and are a main cause of morbidity and mortality (WHO 1999). In actual fact, diabetes has reached epidemic proportions all over the world (Agrawal et al, 2011). Uncontrolled diabetes is resulted in increased risk of microvascular and macrovascular complications (Nathan et al, 2009;Nazimek-Siewniak et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Guideline adherence and control of diabetes mellitus with or without co-morbidities in various wards of a tertiary hospital in Malaysia

et al. 2014

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To assess the adherence of physicians involved in the management of diabetes mellitus with or without co-morbidities with reference to Clinical Practice Guideline 2009 given by Ministry of Health Malaysia in the tertiary care hospital, Pinang General Hospital Malaysia. Cross-sectional study was done at tertiary care hospital, Penang, Malaysia. The total 51 physicians and 1020 patients prescriptions written by same physicians were taken from the record of the Penang General Hospital (20 prescriptions for each enrolled physician). All 1020 patients were suffering from diabetes mellitus with or without co-morbidities. These patients were recruited from the different wards of the Penang General Hospital. Depending on the recommendations of CPG 2009 the prescriptions of patients were divided into adherent and non-adherent prescriptions. The overall good level of physician adherence was seen with respect to the recommendations of CPG 2009 in all prescriptions. A statistically significant negative association (?= 0.094, p-value=0.003) was observed between diabetes mellitus control and co-morbidities. CPG adherent had statistically weak negative association (?= -0.081, p-value=0.010) with patients having co-morbidities. No statistically significant association was observed between CPG adherence and any other co-morbidity. The study explored the several features of prescription pattern of physicians involved in the management of diabetes mellitus with or without co-morbidities and recognized the need for improvement in their prescription pattern for treating the diabetes mellitus.DOI: http://dx.doi.org/10.3329/icpj.v3i8.19405 International Current Pharmaceutical Journal, July 2014, 3(8): 309-312

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Association of macrovascular complications of type 2 diabetes mellitus with serum magnesium levels

Cited by 33 publications

References 17 publications

Associations of Serum and Urinary Magnesium with the Pre-Diabetes, Diabetes and Diabetic Complications in the Chinese Northeast Population

Associations of Serum and Urinary Magnesium with the Pre-Diabetes, Diabetes and Diabetic Complications in the Chinese Northeast Population

Effect of magnesium supplementation on type 2 diabetes associated cardiovascular risk factors: a systematic review and meta‐analysis

Guideline adherence and control of diabetes mellitus with or without co-morbidities in various wards of a tertiary hospital in Malaysia

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