Association of Maternal Report of Infant and Toddler Gastrointestinal Symptoms With Autism

Bresnahan, Michaeline; Hornig, Mady; Schultz, Andrew F.; Gunnes, Nina; Hirtz, Deborah; Lie, Kari Kveim; Magnus, Per; Reichborn‐Kjennerud, Ted; Roth, Christine; Schjølberg, Synnve; Stoltenberg, Camilla; Surén, Pål; Süsser, Ezra; Lipkin, W. Ian

doi:10.1001/jamapsychiatry.2014.3034

Cited by 119 publications

(102 citation statements)

References 39 publications

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“…Several lines of evidence support this idea. First , some individuals diagnosed with ASD present dysbiosis of the gut microbiota and gastrointestinal issues (Bresnahan et al, 2015; Mayer et al, 2014; Parracho et al, 2005). Second , maternal obesity leads to alterations in the offspring’s gut microbiome in humans and non-human primates (Galley et al, 2014; Ma et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, maternal obesity has been associated with alterations in the gut microbiome in offspring in both human and non-human primates (Galley et al, 2014; Ma et al, 2014). In addition, some individuals with neurodevelopmental disorders including ASD co-present with gastrointestinal problems and dysbiosis of the gut microbiota (Bresnahan et al, 2015; Mayer et al, 2014; Parracho et al., 2005). Given the large body of preclinical literature supporting the notion that a bidirectional communication system between the gut and the brain—known as the gut-brain axis—links gut and brain activities (Cryan and Dinan, 2012; Mayer et al, 2015), it has been speculated that changes in the gut microbiome may be relevant to the development of behavioral symptoms associated with ASD (Hsiao et al, 2013; Mayer et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring

Buffington

Prisco

Auchtung

et al. 2016

Cell

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900

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SUMMARY Maternal obesity during pregnancy has been associated with increased risk of neurodevelopmental disorders, including autism spectrum disorder (ASD), in offspring. Here we report that maternal high fat diet (MHFD) induces a shift in microbial ecology that negatively impacts offspring social behavior. Social deficits and gut microbiota dysbiosis in MHFD offspring are prevented by co-housing with offspring of mothers on a regular diet (MRD) and transferable to germ-free mice. In addition, social interaction induces synaptic potentiation (LTP) in the ventral tegmental area (VTA) of MRD, but not MHFD offspring. Moreover, MHFD offspring had fewer oxytocin immunoreactive neurons in the hypothalamus. Using metagenomics and precision microbiota reconstitution, we identified a single commensal strain that corrects oxytocin levels, LTP, and social deficits in MHFD offspring. Our findings causally link maternal diet, gut microbial imbalance, VTA plasticity and behavior, and suggest that probiotic treatment may relieve specific behavioral abnormalities associated with neurodevelopmental disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring

Buffington

Prisco

Auchtung

et al. 2016

Cell

933

900

View full text Add to dashboard Cite

show abstract

“…15 Studies by other investigators since then have confirmed an increase in gastrointestinal symptoms, including a recent study of infant symptom data collected prospectively before the children received an autism diagnosis. 16 The confirmation of an increased rate of gastrointestinal problems, especially constipation, led to network clinicians developing a best-practice pathway for the management of constipation in ASD. 17 These studies have also attempted to better identify clinical phenotypes.…”

Section: Discussionmentioning

confidence: 99%

The Autism Speaks Autism Treatment Network Registry Data: Opportunities for Investigators

et al. 2016

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OBJECTIVE: Patient registries can effectively collect data over a long period of time to provide a better understanding of the typical presentation of specific conditions. The autism spectrum disorders (ASDs) have experienced a marked increase in reported prevalence over the past 20 years for reasons that are not completely clear. The Autism Treatment Network (ATN) Registry was established to facilitate investigations into a variety of questions critical to expanding our understanding of ASDs. Here we describe the establishment of the registry, its components, some of its findings to date, and opportunities for further use of this data. METHODS:Participants are eligible for enrollment into the ATN registry if they are between the ages of 2.0 and 17.6 years at the time of enrollment and meet criteria for ASD as determined by clinical consensus on the basis of specific diagnostic measures (Autism

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“…Otizm tanısı konulmuş bebeklerde, gastrointestinal semptomların görülme prevalansının oldukça yüksek olduğu ve bu çocuklarda yaşamın ilk 3 yılında diyare, konstipasyon, besin allerjisi/intoleransı gibi gastrointestinal semptomların daha fazla görüldüğü rapor edilmiştir. 29 Gastrointestinal semptomlar ve otizm semptomları arasındaki ilişkinin; mitokondri fonksiyonlarında bozulma ve barsak inflamasyonu arasındaki bir etkileşimden kaynaklandığı düşü-nülmektedir. Mitokondri enzimlerinde bozulma veya taşınmasında meydana gelen hasarlar otizmli bireylerde oldukça sık görülmekle birlikte, mitokondriyal diğer hastalıklarda da gastrointestinal semptomlarla çoğunlukla karşılaşılmaktadır.…”

Section: Gastroi̇ntesti̇nal Semptomlar Ve Mi̇krobi̇yota İli̇şki̇si̇unclassified

A Current Approach to Microbiota: Autism and Microbiota

KILINÇ¹,

Söğüt²

2018

Turkiye Klinikleri J Health Sci

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Ö ÖZ ZE ET T Otizm; prevalansı gittikçe artan, ülkemizde ve dünya çapında çok sayıda bireyi etkileyen gelişimsel bir bozukluktur. Otizm, genetik ve çevresel etmenlere bağlı olarak ortaya çıkmaktadır. Fakat otizm etiyolojisinde rol oynayan asıl mekanizma tam olarak bilinememektedir. İntestinal mikrobiyotası, insan sağlığı için esansiyel olmakla birlikte; gastrointestinal sistem ve santral sinir sistemi arasındaki iletişim yoluyla birçok nöropsikiyatrik hastalıkta rol oynamaktadır. Güncel veriler, intestinal mikrobiyotanın otizm ile ilişkili olduğunu ortaya koymaktadır. İntestinal mikrobiyota, aynı zamanda çeşitli mekanizmalarla gastrointestinal fizyoloji, immün foksiyon ve hatta davranış-lar üzerinde etkili olabilmektedir. Aynı zamanda Clostridium, Desulfovibrio ve Sutterella üyeleri gibi bazı intestinal bakterilerin otizmli bireylerde davranış değişikliklerine neden olarak, otizm patogenezinde rol oynayabileceği saptanmıştır. Bu bakımdan, otizm semptomlarının oluşum ve gelişiminde intestinal mikrobiyotadaki bozuklukların sebep olup olmadığını anlamak için otizm ile intestinal mikrobiyotadaki bazı spesifik türlerle ve mevcut çeşitli mekanizmalarla olan ilişkisinin incelenmesi oldukça önemlidir. Bu çalışmada, intestinal mikrobiyotanın otizm semptomları üzerin-deki etkilerinin ve intestinal mikrobiyota ile immün sistem, barsak fonksiyonları ve davranışlar arasındaki mekanizmaların incelenmesi amaçlanmıştır. Ayrıca, intestinal mikrobiyotanın otizmde rol oynayabileceğini destekleyen çeşitli çalışmalarla bu mekanizmalar tartışılmıştır. Güncel bilgiler, çeşitli mekanizmalarla beyin ve davranışları etkileyen birçok hastalık için umut kaynağı olabilmekte ve intestinal mikrobiyotadaki değişikliklerle nörogelişimsel hastalıkların semptomlarının iyileşmesine katkıda bulunabilmektedir.A An na ah ht ta ar r K Ke el li im me el le er r: : Metagenom; otistik bozukluk A AB BS ST TR RA AC CT T The prevalence of autism is a developmental disorder affecting a large number of individuals in our increasingly country and world-wide. Autism is caused by genetic and environmental factors. But the actual mechanism that plays a role in the etiology of autism is not fully known. Intestinal microbiota is essential for human health and plays a role in many neuropsychiatric diseases through communication between gastrointestinal system and central nervous system. Current data suggest that intestinal microbiota is associated with autism. Intestinal microbiota can also influence gastrointestinal physiology, immunological function and even behavior through various mechanisms. It has also been found that some intestinal bacteria such as Clostridium, Desulfovibrio and Sutterella may play a role in the pathogenesis of autism by causing behavioral changes in autistic individuals. In this regard, in order to understand whether the occurrence and development of autism symptoms are caused by intestinal microbiological disorders, it is important to examine the relationship between autism and some specific species in the intestinal microbiota and present...

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Association of Maternal Report of Infant and Toddler Gastrointestinal Symptoms With Autism

Cited by 119 publications

References 39 publications

Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring

Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring

The Autism Speaks Autism Treatment Network Registry Data: Opportunities for Investigators

A Current Approach to Microbiota: Autism and Microbiota

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