Association of Metabolic Syndrome with Hepatic Inflammation and Fibrosis Stage in Nonalcoholic Fatty Liver Disease

Moon, Joon Ho; Park, Sang Hoon; Yoo, Byoung Kwan; Park, Kwang Hyuk; Chung, Yong Woo; Kim, Kyoung Oh; Park, Cheol Hee; Hahn, Taeho; Yoo, Kyo-Sang; Kim, Jong Hyeok; Park, Choong Kee

doi:10.14309/00000434-200609001-00384

Cited by 8 publications

(18 citation statements)

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“…In the current study, patients with NAFLD and hepatic fibrosis had higher age, waist circumference, and BMI in comparison with the control. Similarly, Moon et al . and Angulo et al .…”

Section: Discussionmentioning

confidence: 63%

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Serum ferritin as a non‐invasive marker in the prediction of hepatic fibrosis among Egyptian patients with non‐alcoholic fatty liver disease

et al. 2017

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Background and AimMany studies have found a relationship between hepatic iron, serum ferritin, and non‐alcoholic fatty liver disease (NAFLD) or its progress. The aim of this study is to assess the value of serum ferritin as a non‐invasive marker in the prediction of hepatic fibrosis in NAFLD.MethodsThis study included 113 subjects who were classified into three groups. Group I included 30 healthy subjects as control with no clinical, radiological, and histological features of NAFLD. Group II included 31 NAFLD patients without hepatic fibrosis. Group III included 52 patients with hepatic fibrosis on top of NAFLD.ResultsSerum ferritin was determined using ferritin ELISA kit. Fibrosis 4 score was calculated. Liver biopsy was conducted for included patients. Significantly higher levels of serum ferritin were found in patients with hepatic fibrosis on top of NAFLD than controls. Receiver operating characteristic curve analysis revealed that an optimum cutoff level of 51.95 ng/mL was the best to predict fibrosis on top of NAFLD with diagnostic sensitivity and specificity of 65% and 60%, respectively, and area under the curve = 0.658.ConclusionHigher serum ferritin was found in patients with hepatic fibrosis on top of NAFLD. Serum ferritin was found to be a predictor of fibrosis on top of NAFLD with moderate sensitivity and specificity.

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“…In the current study, patients with NAFLD and hepatic fibrosis had higher age, waist circumference, and BMI in comparison with the control. Similarly, Moon et al . and Angulo et al .…”

Section: Discussionmentioning

confidence: 63%

“…With a recent progress in understanding iron metabolism, accumulating evidence suggests a link between altered iron metabolism and NAFLD. In the last decade, many studies have found a relationship between hepatic iron, serum ferritin, and NASH or its progress …”

Section: Introductionmentioning

confidence: 99%

Serum ferritin as a non‐invasive marker in the prediction of hepatic fibrosis among Egyptian patients with non‐alcoholic fatty liver disease

et al. 2017

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“…Recent advances in functional genomics, both conceptually and technologically, are providing us tremendous opportunities to decipher the interconnecting networks of genes, proteins, and metabolites (Kim et al, 2010a,b;Moon et al, 2006;Pogribny et al, 2007). These global approaches can be generally carried out at four major levels: genome, transcriptome, proteome, and metabolome.…”

Section: Use Of Analytical Approachesmentioning

confidence: 99%

“…We describe following available studies in this contect: (1) Iron is reported to enhance hepatic protection by immune reaction to protect from ischemia injury (Moon et al, 2006). We describe following available studies in this contect: (1) Iron is reported to enhance hepatic protection by immune reaction to protect from ischemia injury (Moon et al, 2006).…”

Section: Nutrition Elements In Nonalcoholic Liver Diseasementioning

confidence: 99%

Biochemical Mechanisms of Fatty Liver and Bioactive Foods

Sharma¹

2013

Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease

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“…This suggests the presence of systemic inflammation unrelated to iron overload. There are a few contradictory reports on the role of the iron burden in patients with NAFLD 21,22. It is not clear whether the elevated serum ferritin is a consequence of systemic inflammation or a marker of iron overload in patients with NAFLD.…”

mentioning

confidence: 99%

Body iron, serum ferritin, and nonalcoholic fatty liver disease

Shim

2012

Korean J Hepatol

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Association of Metabolic Syndrome with Hepatic Inflammation and Fibrosis Stage in Nonalcoholic Fatty Liver Disease

Cited by 8 publications

References 0 publications

Serum ferritin as a non‐invasive marker in the prediction of hepatic fibrosis among Egyptian patients with non‐alcoholic fatty liver disease

Serum ferritin as a non‐invasive marker in the prediction of hepatic fibrosis among Egyptian patients with non‐alcoholic fatty liver disease

Biochemical Mechanisms of Fatty Liver and Bioactive Foods

Body iron, serum ferritin, and nonalcoholic fatty liver disease

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