Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies

Mun, Lee Su; Lum, See Wye; Sze, Genevieve Kong Yuiin; Yoong, Cheong Hock; Yung, Kwek Ching; Lok, Liong Kah; Gopinath, Divya

doi:10.3390/ijerph18147224

Cited by 25 publications

(43 citation statements)

References 59 publications

(281 reference statements)

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“…Evidence from our results suggested that bacteria from the Fusobacterium genus may be considered an oral carcinogenic bacteria. This generalization aligned with the observations reported in the recent reviews by Su Mun et al ( 2021 ) and Alon-Maimon et al ( 2022 ).…”

Section: Analysis Of Results and Discussionsupporting

confidence: 93%

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Systematic review and meta-analysis of oral squamous cell carcinoma associated oral microbiome

Peter

Withanage²,

Comnick³

et al. 2022

Front. Microbiol.

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The intersection between the human oral microbiome and oral health is an emerging area of study which has gained momentum over the last decade. This momentum has motivated a search for associations between the oral microbiome and oral cancer, in hopes of identifying possible biomarkers that facilitate earlier diagnosis and improved prognosis for patients with that disease. The present study examined the relationship between the microbiome in the human oral cavity and oral squamous cell carcinoma (OSCC). We searched the literature for case-control studies which focused on the relationship between the human oral microbiome and OSCC. We aggregated three types of data from these studies: bacteriome data at the genus level, predicted functional pathway data, and gene abundance data. From these data, we noted several microbial genera which may be associated with oral cancer status, including Fusobacterium. We also identified functional pathways which merit further investigation, including RNA degradation (ko03018) and primary immunodeficiency (ko05340). In addition, our analysis of gene abundance data identified the gene K06147 (ATP-binding cassette, subfamily B, bacterial) as being over abundant in OSCC samples. Our results are generalizations which identified some currents that we believe could guide further research. Our work faced several limitations related to the heterogeneity of the available data. Wide variation in methods for sample collection, methods for controlling for known behavioral risk factors, computing platform choice, and methods for case-control design all posed confounding factors in this work. We examined the current methods of data collection, data processing, and data reporting in order to offer suggestions toward the establishment of best practices within this field. We propose that these limitations should be addressed through the implementation of standardized data analytic practices that will conform to the rigor and reproducibility standards required of publicly funded research.

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Section: Analysis Of Results and Discussionsupporting

confidence: 93%

“…The need for such generalizations has been echoed in a recent systematic review by Su Mun et al ( 2021 ). This review provided a qualitative summary of the literature regarding OSCC-microbiome associations and noted the heterogeneity of both the methods and results found in this body of literature.…”

Section: Introductionmentioning

confidence: 99%

Systematic review and meta-analysis of oral squamous cell carcinoma associated oral microbiome

Peter

Withanage²,

Comnick³

et al. 2022

Front. Microbiol.

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“…And so, the association between oral cancers and the residing microbiome is an interesting new direction being explored. Dysbiosis has been linked by multiple studies to the development of oral squamous cell carcinoma (31,32). Based on that and the publications described in the previous paragraph, one can see the correlation between adequate hygiene practices, dysbiosis and the development of oral cancer -and thus the ever so relevant role that prevention may play in clinical practice.…”

Section: Oral Cancermentioning

confidence: 93%

Oral health in a context of public health: prevention-related issue

Berezovsky¹,

Bencko²

2021

Cent Eur J Public Health

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This publication analyses current literary knowledge on selected topics in the fields of oral health and pathology, with a particular emphasis on the potential roles of the oral microbiome and preventative approaches to oral afflictions. An important association with floral dysbiosis has been documented in important oral conditions, sometimes as a predisposing factor and at other times as a result thereof. However, much remains to be elucidated regarding the specific mechanisms at play, as well as their meaning in clinical practice. Continued research into the pathophysiology of certain oral diseases is of particular importance considering how widespread they are. A specific emphasis should be placed on understanding the exact mechanisms through which the microbiota facilitates health, and when disturbed, sickness. And perhaps of most importance is the implementation of knowledge already acquired on disease prevention if the burden of oral diseases worldwide is to decline in the future.

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“…Information on oral microbial dysbiosis in PNI-positive carcinomas is minimal. However, the association of gut microbiota composition with perineural invasion was discussed in colorectal carcinoma ( Kinross et al, 2017 ; Scott et al, 2019 ), and a systematic review of metagenomic studies on the oral microbiome in oral cancer indicate the need to test the correlation of perineural invasion with oral microbiome ( Su Mun et al, 2021 ).…”

Section: The Influence Of Other Epigenetic Factors On the Head And Ne...mentioning

confidence: 99%

Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma

et al. 2022

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Carcinomas of the oral cavity and oropharynx belong among the ten most common malignancies in the human population. The prognosis of head and neck squamous cell carcinoma (HNSCC) is determined by the degree of invasiveness of the primary tumor and by the extent of metastatic spread into regional and distant lymph nodes. Moreover, the level of the perineural invasion itself associates with tumor localization, invasion’s extent, and the presence of nodal metastases. Here, we summarize the current knowledge about different aspects of epigenetic changes, which can be associated with HNSCC while focusing on perineural invasion (PNI). We review epigenetic modifications of the genes involved in the PNI process in HNSCC from the omics perspective and specific epigenetic modifications in OSCC or other neurotropic cancers associated with perineural invasion. Moreover, we summarize DNA methylation status of tumor-suppressor genes, methylation and demethylation enzymes and histone post-translational modifications associated with PNI. The influence of other epigenetic factors on the HNSCC incidence and perineural invasion such as tobacco, alcohol and oral microbiome is overviewed and HPV infection is discussed as an epigenetic factor associated with OSCC and related perineural invasion. Understanding epigenetic regulations of axon growth that lead to tumorous spread or uncovering the molecular control of axon interaction with cancer tissue can help to discover new therapeutic targets for these tumors.

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Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies

Cited by 25 publications

References 59 publications

Systematic review and meta-analysis of oral squamous cell carcinoma associated oral microbiome

Systematic review and meta-analysis of oral squamous cell carcinoma associated oral microbiome

Oral health in a context of public health: prevention-related issue

Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma

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