Association of miR-146a rs2910164 with childhood IgA nephropathy

Lin, Junhong; Huang, Yu‐Huei; Zhang, Xuelin; Chen, Junbin; Sheng, Haihui

doi:10.1007/s00467-014-2818-3

Cited by 23 publications

(16 citation statements)

References 37 publications

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“…There were 406 articles matching the searching strategy, and additional 5 articles [ 20 , 23 , 25 , 28 , 31 ] were included by scanning the references of original papers. After step by step of screening the titles, abstracts and full-texts of the articles, as shown in Fig 1 , 21 articles were recognized appropriate for this meta-analysis, including 24 studies for rs2910164, 11 studies more than the previous meta-analysis published in 2014 [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis of MicroRNA-146a rs2910164 G>C Polymorphism Association with Autoimmune Diseases Susceptibility, an Update Based on 24 Studies

Zhou

et al. 2015

PLoS ONE

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BackgroundPublished data showed that the susceptibility of autoimmune diseases (ADs) was associated with the polymorphism rs2910164 in microRNA-146a (miR-146a). However, the results remain controversial so far. Two meta-analyses published in 2013 and 2014 came to opposite conclusions. In order to derive a more precise estimation of the relationship, we performed this meta-analysis.MethodsWe searched the PubMed, OvidSP and CNKI databases (published prior to September 8th, 2014) and extracted data from eligible studies. The procedure of meta-analysis was performed by using the Stata 12.0 software. Random effect model or fixed effect model were chosen respectively, according to the between study heterogeneities.ResultsA total of 24 case-control studies, 11 more than previous meta-analysis on this topic, were involved. We took stratified analyses by different ethnicities and different types of diseases in different genetic models. In Caucasian subgroup, significant increased risks of GC genotype and GC+CC genotype with ADs susceptibility were found in heterozygote model (GC vs GG, OR = 1.38, 95% CI 1.04–1.83, p = 0.024) and dominant model (GC+CC vs GG, OR = 1.37, 95% CI 1.01–1.85, p = 0.041), respectively. Meanwhile, in other disease subgroup, significant increased risks of C allele, CC genotype and GC+CC genotype were found in allele model (C vs G, OR = 1.16, 95% CI 1.04–1.31, p = 0.010), homozygote model (CC vs GG, OR = 1.42, 95% CI 1.10–1.84, p = 0.006) and dominant model (GC+CC vs GG, OR = 1.25, 95% CI 1.04–1.51, p = 0.020), respectively.ConclusionsMiR-146a rs2910164 G>C polymorphism was associated with the susceptibility of ADs.

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Section: Resultsmentioning

confidence: 99%

Meta-Analysis of MicroRNA-146a rs2910164 G>C Polymorphism Association with Autoimmune Diseases Susceptibility, an Update Based on 24 Studies

Zhou

et al. 2015

PLoS ONE

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“…Up to one third of human genes are under the control of miRNAs [11], but the study of the relationship between miRNAs and the development of IDD is limited [12,13]. A growing body of evidence suggests that single nucleotide polymorphisms (SNPs) in pre-miRNA genes may interfere with the mature processing or the degradation of miRNA by compromising the secondary structure and causing a reduction of the amount of mature miRNA, which attenuates or abolishes the inhibition of the target genes [14][15][16]. Furthermore, functional SNPs located in pre-miRNA may be associated with altered susceptibility to numerous diseases, including cancer, reproductive disorders and degenerative diseases [17,18].…”

Section: Introductionmentioning

confidence: 99%

MiR-125a Rs12976445 Polymorphism is Associated with the Apoptosis Status of Nucleus Pulposus Cells and the Risk of Intervertebral Disc Degeneration

Feng

Zang

et al. 2016

Cell Physiol Biochem

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Background: Spinal degenerative diseases are a major health problem and social burden worldwide. Intervertebral disc degeneration (IDD) is the pathological basis of spinal degenerative diseases and is characterized by loss of nucleus pulposus cells due to excessive apoptosis caused by various factors. MicroRNAs (miRNAs) have been reported to be functionally involved in the control of apoptosis. Methods: computational analysis and luciferase assay were used to identify the target of miR-125a, and cell culture, transfection were used to confirm such relationship. Sequencing was used to determine the genotype of each participant. Results: We confirmed the previous report that the presence of the minor allele (T) of rs12976445 polymorphism significantly downregulated the expression level of miR-125a in nucleus pulposus cells, leading to less efficient inhibition of its target gene. We also validated TP53INP1 as a target of miR-125a in nucleus pulposus cells using a dual luciferase reporter system, and the transfection of miR-125a significantly reduced the expression of TP53INP1. The expression level of TP53INP1 was significantly lower in nucleus pulposus cells genotyped as CT or TT than in those genotyped as CC, and the apoptosis rate was consistently lower in the CC group than in the nucleus pulposus cells collected from individuals carrying at least one minor allele of rs12976445 polymorphism. To study the association between rs12976445 polymorphism and the risk of IDD, we enrolled 242 patients diagnosed with IDD and 278 normal controls, and significant differences were noted regarding the genotype distribution of rs12976445 between the IDD and the control groups (OR = 2.69, 95% C.I. = 1.88-3.83, p < 0.0001). In summary, rs12976445 polymorphism is significantly associated with the risk of IDD in the Chinese population. Conclusion: The present study indicated that miR-125a is a promising potential target for patients with IDD in clinical practice.

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“…Three functional SNPs in miRNA‐146a (rs57095329, rs2910164 and rs2431697) affected miRNA‐146a expression and are involved in many diseases by targeting FAS . The three SNPs were found to play an important role in various diseases, such as susceptibility to BD , cancers , juvenile idiopathic arthritis‐enthesitis‐related arthritis (JIA‐ERA) , ischaemic stroke , IgA nephropathy (IgAN) , CAD and drug‐resistant epilepsy (DRE) , while the severity of temporal lobe epilepsy (TLE) was not assessed .…”

Section: Mirna‐137mentioning

confidence: 99%

“…Three functional SNPs in miRNA-146a (rs57095329, rs2910164 and rs2431697) affected miRNA-146a expression and are involved in many diseases by targeting FAS (39,76). The three SNPs were found to play an important role in various diseases, such as susceptibility to BD (24,30), cancers (29), juvenile idiopathic arthritis-enthesitis-related arthritis (JIA-ERA) (31), ischaemic stroke (32), IgA nephropathy (IgAN) (33,84), CAD (34) and drug-resistant epilepsy (DRE) (41), while the severity of temporal lobe epilepsy (TLE) was not assessed (85). The rs2910164 polymorphism, which is located in the stem region of the miR-146a precursor and regulates the expression of mature miRNA-146a, is characterized by a change from G to C, resulting in low expression of miRNA-146a and abnormal target mRNA binding (86,87).…”

Section: Snps Of Mirna-146amentioning

confidence: 99%

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Associations ofmicroRNAsingle nucleotide polymorphisms and disease risk and pathophysiology

2017

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Single nucleotide polymorphisms (SNPs) are genetic variations that contribute to human phenotypes associated with various diseases. SNPs are involved in the regulation of a broad range of physiological and pathological processes, such as cellular senescence, apoptosis, inflammation, and immune response, by upregulating the expression of classical inflammation markers. Recent studies have suggested that SNPs located in gene-encoding microRNAs (miRNAs) affect various aspects of diseases by regulating the expression or activity of miRNAs. In the last few years, miRNA polymorphisms that increase and/or reduce the risk of developing many diseases, such as cancers, autoimmune diseases, and cardiovascular diseases, have attracted increasing attention not only because of their involvement in the pathophysiology of diseases but also because they can be used as prognostic biomarkers for a variety of diseases. In this review, we summarize the relationships between miRNA SNPs and the pathophysiology and risk of diseases.

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Association of miR-146a rs2910164 with childhood IgA nephropathy

Abstract: These results indicated that rs2910164 may affect the susceptibility and severity of pediatric IgAN. Further studies are needed to validate these findings.

Cited by 23 publications

References 37 publications

Meta-Analysis of MicroRNA-146a rs2910164 G>C Polymorphism Association with Autoimmune Diseases Susceptibility, an Update Based on 24 Studies

Meta-Analysis of MicroRNA-146a rs2910164 G>C Polymorphism Association with Autoimmune Diseases Susceptibility, an Update Based on 24 Studies

MiR-125a Rs12976445 Polymorphism is Associated with the Apoptosis Status of Nucleus Pulposus Cells and the Risk of Intervertebral Disc Degeneration

Associations ofmicroRNAsingle nucleotide polymorphisms and disease risk and pathophysiology

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