Association of Muscle Strength With the Risk of Alzheimer Disease and the Rate of Cognitive Decline in Community-Dwelling Older Persons

Boyle, Patricia A.; Buchman, Aron S.; Wilson, Robert S.; Leurgans, Sue E.; Bennett, David A.

doi:10.1001/archneurol.2009.240

Cited by 331 publications

(310 citation statements)

References 46 publications

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“…In their systematic review, Clouston et al 33) reported finding an association between grip strength and cognitive function, with grip strength predicting the development of Alzheimer's disease 34) . However, they concluded that the associations between grip strength and cognitive function were not sufficiently strong to provide conclusive evidence for "common cause" aging.…”

Section: Validity As a Predictor Of Geriatric Concernsmentioning

confidence: 99%

Grip strength and healthy aging

Kozakai

2017

JPFSM

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Section: Validity As a Predictor Of Geriatric Concernsmentioning

confidence: 99%

Grip strength and healthy aging

Kozakai

2017

JPFSM

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“…After a literature search conducted in a quasi-systematic manner, 15 papers, including 14 prospective cohort studies [9][10][11][12][13][14][15][16][17][18][19][20]22,23) and one meta-analysis study 21) , were identified and are summarized in Table 1. Overall, most studies examined participants older than 70 years of age at baseline except two studies recruiting middle-aged participants 17,18) .…”

Section: Recent Findings Regarding the Associationmentioning

confidence: 99%

“…Overall, most studies examined participants older than 70 years of age at baseline except two studies recruiting middle-aged participants 17,18) . Baseline cognitive status was reported in 13 studies [9][10][11][12][13][14][15][16][19][20][21][22][23] . In these studies, participants were non-demented at baseline, but two studies included individuals with mild cognitive impairment (MCI) at baseline as a small part of the participants 11,21) .…”

Section: Recent Findings Regarding the Associationmentioning

confidence: 99%

Association between middle- to late-life physical performance and incident Alzheimer's disease: Recent findings and potential mechanisms

Narazaki

Nofuji

Kumagai

2017

JPFSM

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Dementia is recognized as one of the major formidable public health challenges in modern aging societies. Among the several subtypes of dementia, Alzheimer's disease (AD) is the most frequent, probably accounting for 40-50% of total dementia cases. Recent findings from prospective cohort studies suggest that impairment, found in certain physical performance measures, precedes the clinical diagnosis of AD. The main aim of this review paper is to provide a brief summary of recent findings regarding the associations between middle-to late-life physical performance measures and incident AD and total dementia including AD. This paper also aims to discuss the potential mechanisms underlying the prospective associations between physical performance and incident AD. The reviewed findings suggest that poor baseline status in physical performance measures, including gait performance, muscle strength, balance, aerobic performance, and composite physical performance, is associated with greater risk for the subsequent incidence of AD. Preclinical pathologies leading to AD and physical fitness are named as part of plausible factors underlying the prospective association between physical performance and incident AD. It is also speculated that the prospective association is mostly noncausal, where physical performance measures probably serve as "early markers" of the future incidence of AD. Further studies are expected to establish solid evidence of the prospective association, to clarify the whole picture of the mechanisms underlying the association, and to explore the practical application of physical performance measures in attempts to identify individuals at a higher risk of AD before or early in the disease.

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“…Worldwide we have an emergence of data supporting the use of physical activity throughout the lifespan to prolong wellbeing and reduce the risk of later-life disability and morbidity; yet few populations are embracing the international guidelines recommending 30 minutes of physical activity, every day of the week, that incorporate aerobic, strengthening, balance and flexibility components. [64][65][66] Many gerontologists claim that research on aging should not focus on increasing total lifespan, but rather on extending a healthy lifespan, defined as the total number of years a person remains in good health. Given the negative health outcomes associated with obesity, reductions in weight among older adults is an important key to prolonged health.…”

Section: Healthy Lifespan and Exercisementioning

confidence: 99%

“…Given the negative health outcomes associated with obesity, reductions in weight among older adults is an important key to prolonged health. For older adults, regular physical activity (including exercise), that is important in the prevention and management of various chronic diseases, can reduce physical decline and prolong functional capacity in the activities of daily living, and, in addition, reduce the risk of falls and cognitive decline [64][65][66] .…”

Section: Healthy Lifespan and Exercisementioning

confidence: 99%

Exercise, diet, and weight loss

Tanaka¹,

Shigematsu²,

Henwood³

et al. 2012

JPFSM

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Japan is one of the most rapidly aging countries in the world. "Healthy Japan 21" is a Japanese government initiative promoting lifestyle-related disease prevention, health promotion, and successful aging. Increasing physical activity participation among older Japanese, the least physically active of any age group, is especially important for preventing frailty and chronic disease, and the associated health care expenditure. Informed by the research we have to date, the following evidence-based conclusions can be drawn relative to exercise and physical activity for the obese population. A combination of aerobic exercise, resistance exercise and physical activities, in addition to proper diet (mostly caloric restriction: 1200 kcal for women and 1680 kcal for men for a certain period of time), is more effective than either form of intervention alone for reducing body weight, visceral fat, blood pressure, and many other negative health-related variables. Exercise habituation in conjunction with proper diet is also most effective for improving vital age. Incorporating and adhering to these lifestyle factors, coupled with adherence to other known health modifiers (reduced stress, improved sleep, etc) will help reduce individual and population obesity and improve national health.

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Association of Muscle Strength With the Risk of Alzheimer Disease and the Rate of Cognitive Decline in Community-Dwelling Older Persons

Cited by 331 publications

References 46 publications

Grip strength and healthy aging

Grip strength and healthy aging

Association between middle- to late-life physical performance and incident Alzheimer's disease: Recent findings and potential mechanisms

Exercise, diet, and weight loss

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