Association of N-terminal pro B-type natriuretic peptide and sex hormone-binding globulin in non-obese peri- and postmenopausal women

Matsui, Shinji; Saijo, Ayako; Kaji, Takashi; Yamamoto, Shozo; Uemura, Hirokazu; Matsuzaki, Takashi; Irahara, Minoru

doi:10.1016/j.cca.2009.11.025

Cited by 7 publications

(12 citation statements)

References 26 publications

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“…The change in circulating testosterone level during the menopausal transition is controversial [6,18,19]. We previously showed that levels of free and bioavailable testosterone in postmenopausal women were significantly lower than those in pre-and perimenopausal women [20]. Furthermore, in early and late postmenopause, we showed that adiponectin levels were negatively correlated with free and bioavailable testosterone.…”

Section: Discussionmentioning

confidence: 85%

Association of circulating adiponectin with testosterone in women during the menopausal transition

et al. 2012

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Section: Discussionmentioning

confidence: 85%

Association of circulating adiponectin with testosterone in women during the menopausal transition

et al. 2012

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“…On the other hand, recent experimental(13,14) and cross-sectional human data(8,15) suggest that androgens may exert an inhibitory effect on the NP system, thus accounting for the lower NP levels in men and potentially explaining the lack of cardiovascular protection in men compared with women. (8) However, prior clinical studies of the influence of androgens on NPs were limited to studying women(8,16) or children,(15) and did not fully characterize both endogenous (menstrual phase) and exogenous (hormone therapy) variations. Further, previous investigations did not include measures of insulin resistance, which is a potential confounder since hyperinsulinemia is known to be associated with both sex hormones (hyperandrogenemia) and lowered NP concentrations.…”

Section: Introductionmentioning

confidence: 99%

Influence of Sex and Hormone Status on Circulating Natriuretic Peptides

Lam

Cheng

Choong

et al. 2011

Journal of the American College of Cardiology

151

113

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Objectives To assess the relationship between sex hormones and natriuretic peptide levels in community-based adults Background Women have higher circulating natriuretic peptide concentrations than men, but the mechanisms for these sex-related differences and the impact of hormone therapy are unclear. Experimental studies suggest that androgens may suppress natriuretic peptide secretion. Methods We measured plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP), total testosterone, and sex hormone binding globulin (SHBG) in 4,056 men and women (mean age 40±9 years) from the Framingham Heart Study Third Generation cohort. Sex/hormone status was grouped as: 1) men, 2) postmenopausal women not receiving hormone replacement therapy, 3) premenopausal women not receiving hormonal contraceptives, 4) postmenopausal women receiving hormone replacement therapy and 5) premenopausal women receiving hormonal contraceptives. Results Circulating NT-proBNP was associated with sex/hormone status (overall P<0.0001). Men had lower NT-proBNP than women of all menopause or hormone groups, and women receiving hormonal contraceptives had higher NT-proBNP than women who were not receiving hormone therapy (all P<0.0001). These relationships remained significant after adjusting for age, body mass index, and cardiovascular risk factors. Across sex/hormone status groups, FT decreased and SHBG increased in tandem with increasing NT-proBNP. In sex-specific analyses, NT-proBNP decreased across increasing quartiles of free testosterone in men (P for trend<0.01) and in women (P for trend<0.0001). Adjustment for FT markedly attenuated the association between sex/hormone status and NT-proBNP concentrations. Conclusions These findings suggest that lower circulating androgens and the potentiating effect of exogenous female hormone therapy contribute to the higher circulating NT-proBNP concentrations in women.

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“…Natriuretic peptides have proangiogenic, antihypertrophic and vasodilatory effects on the cardiovascular system and are also counter-regulators of RAAS and the adrenergic systems. 7, 8, 13, 16 Increased NT-proBNP may indicate cardioprotective actions 8, 13, 16 against the deleterious effects of estrogen loss on the hearts of early menopausal women. Other sex hormones such as testosterone and progesterones could also contribute to cardioprotective mechanisms 43 in the hearts of postmenopausal females.…”

Section: Discussionmentioning

confidence: 99%

“…Some factors that affect NT-proBNP such as age, 13 smoking, 14 ethnicity 15 and body mass index (BMI) 8, 11, 13, 16, 17 could also affect menopausal age. 18–21 Women have greater NT-proBNP than men 8, 13 and menopause, a consequence of aging 22 occurs specifically in women.…”

Section: Introductionmentioning

confidence: 99%

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Association of menopause age and N-terminal pro brain natriuretic peptide

et al. 2015

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Objective Menopausal age could affect the risk of developing cardiovascular disease (CVD). The purpose of this study was to investigate the associations of early menopause (menopause occurring before 45 years of age) and menopausal age with NT-pro brain natriuretic peptide (NT-proBNP), a potential risk marker of CVD and heart failure (HF). Methods Our cross-sectional study included 2275 postmenopausal women, aged 45–85 years, without clinical CVD (2000–2002), from the Multi-Ethnic Study of Atherosclerosis. Participants were classified as having or not having early menopause. NT-proBNP was log-transformed. Multivariable linear regression was used for analysis. Results There were 561 women with early menopause. The median NT-proBNP value was 79.0 (41.1–151.6) pg/ml for all participants with values of 83.4 (41.4–164.9) pg/ml and 78.0 (40.8–148.3) pg/ml for women with and without early menopause respectively. The mean (SD) age was 65 (10.1) and 65 (8.9) years for women with and without early menopause respectively. There were no significant interactions between menopausal age and ethnicity. In multivariable analysis, early menopause was associated with a 10.7% increase in NT-proBNP while each year increase in menopausal age was associated with a 0.7% decrease in NT-proBNP. Conclusion Early menopause is associated with greater NT-proBNP levels while each year increase in menopausal age is associated with lower NT-proBNP levels in postmenopausal women.

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Association of N-terminal pro B-type natriuretic peptide and sex hormone-binding globulin in non-obese peri- and postmenopausal women

Cited by 7 publications

References 26 publications

Association of circulating adiponectin with testosterone in women during the menopausal transition

Association of circulating adiponectin with testosterone in women during the menopausal transition

Influence of Sex and Hormone Status on Circulating Natriuretic Peptides

Association of menopause age and N-terminal pro brain natriuretic peptide

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