Association of Parvovirus B19 Infection with Systemic Lupus Erythematosus: Role of Th1 Predominance

Immunologic Storm Simulating Systemic Lupus Erythematosus Following Parvovirus B19 Infection

“…infection [34], and IL12 is usually increased in SLE patients [31]. It is remarkable that in our case, although normal levels are maintained at the beginning, there is a drastic increase and maximum values are reached on the third determination.…”

“…While IL--6 is related with autoimmune processes and with arthralgia [31], IL--10 can indicate clinical manifestations similar to those typical of SLE [32,33]. IFNγ determinations are of great importance, as its presence can indicate the persistence of PVB19 infection.…”

The effects of co-infection with human parvovirus B19 and Plasmodium falciparum on type and degree of anaemia in Ghanaian children

“…In addition, some case studies have also reported of B19V induced severe anaemia following malaria infection and successful treatment with antimalarials [46][47][48][49][50] . Though it is primarily known to cause erythematous rash, foetal hydrops and other involvements in various haematological disorders, B19V is also involved in other conditions [34,[51][52][53][54][55][56][57] . B19V in many occasions have been reported as a bystander or contributor to many conditions such as hepatitis, myocarditis, arthritis among others [58][59][60][61][62][63][64][65][66][67] .…”

Human Parvovirus B19-Induced Acute Glomerulonephritis: A Case Report

“…In general, molecular mimicry seems to be one reason for viral-induced autoantigen production. 20 Park et al 21 have demonstrated that Th1-associated cytokines play a crucial role in the pathogenesis and development of SLE after HPVB19 infection. Hession et al 22 contend that the relative antinuclear antibody titers may be a prognostic indicator as to which patients will develop chronic HPVB19-induced SLE, as opposed to mere transient symptoms.…”