Association of pericoronary fat volume with atherosclerotic plaque burden in the underlying coronary artery: A segment analysis

The Association of Pericardial Fat with Coronary Artery Plaque Index at MR Imaging: The Multi-Ethnic Study of Atherosclerosis (MESA)

“…The same report indicated that pericardial fat volume was not signifi cantly different between patients with noncalcifi ed plaque, patients with mixed plaque types, and those with calcifi ed plaque. However, the results from recent studies ( 9,10 ) indicate that the amount of epicardial fat is associated strongly with the presence of plaque overall and primarily with the presence of noncalcifi ed plaque. In these studies, the predominant method used to assess coronary atherosclerosis thickness in the univariate model only ( P , .05), but this relationship was not signifi cant in women.…”

The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells

“…We found a close relationship between PVAT mass and insulin sensitivity [11]. Thus PVAT represents a novel and important fat compartment for the regulation of insulin sensitivity and vascular function independently of other fat compartments [12][13][14][15][16][17].…”

Molecular Biology of Atherosclerosis

“…Furthermore, perivascular fat was much more proinflammatory than fat from other sources and showed greatly increased release of TNF-␣, MCP-1 (CCL2), and MIP-1␣ (CCL3) upon high-fat feeding (1135). These findings provide new impetus for controlling weight gain and other factors that may increase deposition of coronary perivascular fat, recently shown to be strongly associated with atherosclerotic plaques in humans (1114,1161,1750).…”