Association of polymorphic variants of FTO and MC4R genes with obesity in a Tatar population

Abstract

Obesity is a chronic relapsing disease that leads to numerous ailments and requires lifelong treat ment. Genetic predisposition is one of the mostly discussed aspects of obesity development, and genome wide association studies have provided evidence that several variants of the FTO and MC4R genes are signif icantly associated with obesity. In this study the association of FTO (rs9939609, rs7202116, and rs9930506) and MC4R (rs12970134 and rs17782313) genes' SNPs with obesity in Tatar women has been analyzed. In the investigation 340 women with obesity (Body Mass Index (BMI) ≥ 30 kg/m 2 ) and 330 women from a control group (BMI up to 24.9 kg/m 2 ) took part. The FTO rs9939609 (p = 0.0002) and rs9930506 (p = 0.0005) SNPs were shown to be associated with obesity risk following an additive model, while the MC4R rs12970134 (p = 0.0076) and rs1778231 (p = 0.021) SNPs were associated by a recessive model. We also showed an association of quantitative parameters (age, weight, and BMI) with two the FTO rs9939609 and rs9930506 SNPs and the association of age and the MC4R rs12970134 SNP. Our study demonstrates the role of genetic variability in FTO and MC4R genes in obesity development in Tatar women from Russia.

Interactions with the MC4R rs17782313 variant, mental stress and energy intake and the risk of obesity in Genome Epidemiology Study

“…In several populations, the MAF of MC4R rs17782313 varies from 24 % to 26 %; Therefore, the MAF of MC4R rs17782313 in Koreans (25 %) was comparable to studies in other ethnicities [ 11 , 14 , 16 ]. Those previous studies found that the MC4R rs17782313 C allele was a risk allele for obesity.…”

“…Those previous studies found that the MC4R rs17782313 C allele was a risk allele for obesity. The MC4R rs17782313 CC genotype has a strong positive association with BMI which has been clearly demonstrated in European and Tatar populations in which subjects with the rs17782313 variant had higher BMIs [ 11 , 14 ]. These results suggest that the MC4R minor allele is a risk factor for obesity across ethnicities.…”

“…Among these genes, some single-nucleotide polymorphisms (SNPs) near MC4R (rs17782313, rs571312, rs17700144, and rs2331841) are strongly associated with obesity in adults, adolescents, and children, indicating that subjects with minor alleles of these SNPs typically exhibit higher BMIs than those with the major allele [ 3 , 11 – 13 ]. An association between MC4R rs17782313 and obesity has been reported in a European population [ 11 , 14 ]. There was also a strong association between MC4R rs17782313 polymorphisms in subjects either heterozygous or homozygous for the C allele (CT or CC as opposed to TT) and higher body mass index (BMI) in Tatar women and Chinese people [ 14 , 15 ].…”

“…An association between MC4R rs17782313 and obesity has been reported in a European population [ 11 , 14 ]. There was also a strong association between MC4R rs17782313 polymorphisms in subjects either heterozygous or homozygous for the C allele (CT or CC as opposed to TT) and higher body mass index (BMI) in Tatar women and Chinese people [ 14 , 15 ]. In Korea, the MC4R variant rs17782313 was associated with BMI in a replication gene association study and a GWAS [ 16 , 17 ] and BMI increased with C allele (minor allele) of MC4R rs17782313 by 0.22 kg/m 2 BMI [ 17 ].…”

Searching for Factors Raising the Incidence of Metabolic Syndrome Among 45-60-Year-Old Women

“…Other studies of the same population revealed association between the MC4R C allele and food energy intake, which was regarded as a factor directly related to an elevated risk of obesity [ 49 ]. Higher BMI scores were observed in Chinese people and Tatar women, regardless of whether they were homo- or heterozygotes of the C allele of the MC4R rs17782313 polymorphism (unlike carriers of the T allele) [ 50 , 51 ]. The study of Guan et al did not provide evidence for the relationships between NAFLD and the tested gene polymorphisms [ 46 ].…”