Association of polymorphisms in microRNA-binding sites and colorectal cancer in an Iranian population

Interleukin-16 Gene Polymorphisms rs4778889, rs4072111, rs11556218, and Cancer Risk in Asian Populations: A Meta-Analysis

“…Recently, a variety of studies have highlighted some polymorphisms of the IL-16 gene with regard to susceptibility to a wide range of cancers (Gao et al, 2009a(Gao et al, , 2009bZhu et al, 2010;Azimzadeh et al, 2011Azimzadeh et al, , 2012Li et al, 2011). Three polymorphisms (rs4778889, rs4072111, rs11556218) were substantially explored.…”

Positive Association Between IL-16 rs11556218 T/G Polymorphism and Cancer Risk: a Meta-analysis

“…A total of 15 publications regarding IL-16 gene polymorphisms and cancer risk were identified. Nine publications were excluded after reading the full article in detail, because they were editorial comment, letter, case report, other polymorphism of IL-16, without sufficient data, repeated literatures and violated HWE (Thomas et al, 2008;Obara et al, 2010;Azimzadeh et al, 2012;Batai et al, 2012;Lin et al, 2012;Deng et al, 2012;Du, et al, 2012;Hughes et al, 2013;Zhang et al, 2013). The study of Gao et al (2009b) presented separate OR by colorectal and gastric two cancer types and each of them was considered as a separate study.…”

Variants of Interleukin-16 Associated with Gastric Cancer Risk

“…The IL-16 generally functions as an immunosuppressor and anti-inflammatory mediator, and has been implicated in autoimmune disease and progression of malignancies (Azimzadeh et al, 2012;Yellapa et al, 2012;Li et al, 2011;Gao et al, 2009a). Currently, there was only one study reported the association between IL-16 polymorphisms and risk of gastric cancer (Gao et al, 2009a), and this case-control study indicated that rs11556218T/G and rs4072111C/Tpolymorphisms of the IL-16 gene was significantly associated with the susceptibility to gastric cancer patients.…”