Association of resistin polymorphism, its serum levels and prevalence of stroke in Japanese type 2 diabetic patients

Abstract

Aims/Introduction: Resistin, an inflammatory cytokine, might be involved in the development of atherosclerosis. In a recent paper, we showed that resistin polymorphism might be a risk marker for stroke susceptibility in Japanese type 2 diabetic patients. We tested whether the serum resistin levels might be also a risk marker of stroke independently from RETN polymorphism.Materials and Methods: Type 2 diabetic outpatients from our hospitals were enrolled. Patients (n = 89) with a history of coronary heart disease and stroke, and randomly selected controls (n = 178) matched for sex and age, but without a history of coronary heart disease and stroke, were examined for polymorphism ‐420 (C>G) and cytokines levels.Results: Serum resistin levels were significantly higher in patients with cardiovascular diseases (CVD) than in those without CVD (P = 0.024), and were highest in patients with stroke among the CVD. In multiple logistic regression analysis, serum resistin levels was an independent risk marker of stroke even after adjusted by RETN polymorphism, age, sex, body mass index, HbA1c, systolic and diastolic blood pressure, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, creatinine, history of coronary heart disease, treatment of insulin, sulfonylurea and aspirin (odds ratio 1.33, 95% confidence interval [CI] 1.02–1.73, P = 0.039). The enrolled patients were divided by their serum resistin levels (high or low group) and their genotypes (CC, CG, GG at ‐420) into six groups. Patients with the GG genotype and high resistin levels showed the highest odds ratio, 5.69 (95% CI 1.24–26.1), compared with the group with CC and low levels.Conclusions: The results suggest that serum resistin levels might be a good marker of susceptibility to stroke as well as RETN polymorphism. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.00040.x, 2010)

Relevance Study on Cerebral Infarction and Resistin Gene Polymorphism in Chinese Han Population

“…Investigating Japanese residents over age 40, Osawa discovered not only a positive correlation between the serum resistin level and the occurrence of angiocardiopathy, but an increase in the rate of ischemic accidents induced by an increasing resistin level as well [ 18 ]. The results of Tsukahara and Osawa were also supported by other research, such as the finding of a higher risk for CI in patients with high resistin level and the GG gene type carriers of site rs1862513 announced by Nakashima [ 19 ]. Targeting CI patients, the resistin level influenced not only their disability rates but also their mortality [ 20 ].…”

Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction

“…At the same time, they also had increased levels of triglycerides and higher prevalence of MetS and obesity [ 61 ]. In both females and males, the G allele of the 420C/G of the resistin gene polymorphism appears to be associated [ 70 ] with higher risk for cardiovascular events [ 61 ], cerebrovascular disease, and stroke [ 69 , 71 ]: more severe stroke and higher in-hospital mortality in patients with acute ischemic stroke [ 72 ]. Similarly, subjects with allele 299A (allele +299 (G>A) alleles) exhibited high glucose levels at birth, and in diabetic patients, the resistin levels correlated with cerebrovascular disease especially in males [ 72 ].…”

Visfatin and resistin: Mediators of the pleiotropic effects of incretins?

“…We and others reported that serum resistin levels are increased in a genotype‐dependent manner based on the RETN polymorphism at –420 (C > G). We also showed that the genotyping of this polymorphism might be a good risk marker for stroke susceptibility in Japanese type 2 diabetic patients in a recent paper. However, there have been some conflicting reports that do not support a relationship between the blood resistin levels and susceptibility to cardiovascular diseases.…”

“…We showed in a previous paper that resistin polymorphism and serum resistin levels might be a risk marker for stroke susceptibility in Japanese type 2 diabetic patients. Resistin levels in blood might be regulated by genetic factors in Asians, but also resistin itself might affect the progression of atherosclerotic diseases. We and others reported that serum resistin levels are increased in a genotype‐dependent manner based on the RETN polymorphism at –420 (C > G).…”