Association of retinal biomarkers and choroidal vascularity index on optical coherence tomography using binarization method in retinitis pigmentosa

Çetin, Ebru; Parca, Osman; Akkaya, Hasan Samed; Pekel, Gökhan

doi:10.1007/s00417-019-04516-7

Cited by 11 publications

(10 citation statements)

References 33 publications

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“…The choroidal vascularity index (CVI), defined as the proportion of the luminal area (LA) to the total choroidal area (TCA) (9,10), has been documented to be a more stable and reliable parameter to monitor choroidal vasculature in retinal diseases such as age-related macular degeneration, Vogt-Koyanagi-Harada disease, and in primary open-angle glaucoma (POAG) (11)(12)(13)(14)(15)(16) than the subfoveal choroidal thickness (SFCT). However, no studies have investigated the choroidal vascular changes by using the CVI parameter in eyes with MG.…”

Section: Introductionmentioning

confidence: 99%

Associations Between the Choroidal Vascularity Index and Malignant Glaucoma After Trabeculectomy for Primary Angle Closure Glaucoma

et al. 2021

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Purpose: To compare the choroidal vasculature characteristics by using the choroidal vascularity index (CVI) in eyes with malignant glaucoma (MG), fellow eyes with non-MG, and eyes with uncomplicated primary angle-closure glaucoma (PACG) after trabeculectomy by spectral-domain optical coherence tomography (SD-OCT).Methods: This case–control study included 53 patients diagnosed with MG after trabeculectomy. Eyes with MG (n = 53) and the fellow eyes with non-MG (n = 50) were included. Eyes with PACG without MG after trabeculectomy (n = 60) were also enrolled as controls. The choroidal parameters, including CVI and the subfoveal choroidal thickness (SFCT), were measured by using SD-OCT images.Results: Eyes with MG and the fellow eyes showed a significantly lower CVI than eyes with PACG controls (p < 0.001). After adjusting for age, sex, axial length (AL), and intraocular pressure (IOP), eyes with the greater CVI [odds ratio (OR), 0.44] were significantly related to MG. The area under the receiver operating characteristic curve of the CVI was greater than that of the SFCT in the diagnosis of MG (0.911 vs. 0.840, p = 0.034).Conclusion: Eyes with MG showed a significantly lower macular CVI than eyes with PACG controls. A higher macular CVI was an associated factor of eyes with MG. The CVI serves as a more stable and sensitive indicator for MG than the SFCT in this group of patients with PACG.

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Section: Introductionmentioning

confidence: 99%

Associations Between the Choroidal Vascularity Index and Malignant Glaucoma After Trabeculectomy for Primary Angle Closure Glaucoma

et al. 2021

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“…In some studies, CT measurements at locations other than the macula or subfoveal CT have been attempted in various diseases ( 23 , 79 , 82 , 89 , 104 , 108 ). In others, CT was measured both at the macula and outside the macular region ( 26 , 32 , 77 , 81 ). These studies showed that variations in CT outside the macula can be different from those within it ( 81 , 97 – 101 ).…”

Section: Discussionmentioning

confidence: 99%

“…In others, CT was measured both at the macula and outside the macular region ( 26 , 32 , 77 , 81 ). These studies showed that variations in CT outside the macula can be different from those within it ( 81 , 97 – 101 ). Another approach was to calculate the ratio of different CT measurements ( 32 , 33 , 75 ).…”

Section: Discussionmentioning

confidence: 99%

“…Kang et al ( 80 ) found that the mean peripapillary CT in patients with BRVO and normal-tension glaucoma was significantly lower in eyes with focal laminar cribrosa defects than in those without it. In a recent study, Cetin et al ( 81 ) extended the measurement of peripapillary CT in patients with retinitis pigmentosa. Balci and Turan-Vural measured peripapillary CT in eyes with ocular sarcoidosis and glaucoma ( 82 ).…”

Section: Choroidal Thickness Measurement Beyond the Maculamentioning

confidence: 99%

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Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula

Kim

2021

Front. Med.

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Enhanced depth imaging optical coherence tomography (EDI-OCT) and swept-source OCT (SS-OCT) have emerged as essential diagnostic tools in the study and management of various chorioretinal diseases. Evidence from early clinical studies using EDI-OCT and SS-OCT indicates that choroidal dysfunction plays a major role in the pathogenesis of chorioretinal diseases. Measurement of choroidal thickness (CT) has already become a major research and clinical method, and CT is considered as an indicator of choroidal status in a variety of ophthalmic diseases. Recently, CT measurement has also been proposed as a non-invasive marker for the early detection and monitoring of various systemic diseases. Among the several possible CT measurement locations, subfoveal CT has rapidly become a reliable parameter for measuring CT in healthy and diseased eyes. Moreover, recent advancements in OCT technology have enabled faster and wider imaging of the posterior part of the eye, allowing the various changes in CT as measured outside the macula to be shown accordingly. In this review, we first provide an overview of the results of clinical studies that have analyzed the healthy macular choroid and that in various chorioretinal diseases, and then summarize the current understanding of the choroid outside the macula. We also examine the CT profile as an index that encompasses both within and outside of the macula. Furthermore, we describe the clinical applications of ultrawide OCT, which enables visualization of the far periphery, and discuss the prospects for the development of more reliable choroidal parameters that can better reflect the choroid's characteristics.

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“…EZ disruption was also considered as positive if the EZ line was not visible. DRIL was defined as the inability to identify the boundaries between the ganglion cell-inner plexiform layer complex, inner nuclear layer, and outer plexiform layer within the 1000-μm diameter of fovea on the horizontal or vertical OCT images [ 14 , 15 ]. The presence of EZ disruption and DRIL was determined by agreement between two observers (DS and YH).…”

Section: Methodsmentioning

confidence: 99%

Use of ellipsoid zone width for predicting visual prognosis after cataract surgery in patients with retinitis pigmentosa

Sakai

Takagi

Hirami

et al. 2022

Eye

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Objective To predict the visual prognosis of cataract surgery in patients with retinitis pigmentosa by measuring ellipsoid zone (EZ) width using spectral-domain optical coherence tomography. Methods This retrospective study included patients with retinitis pigmentosa who underwent uncomplicated cataract surgery between December 2017 and June 2020. Preoperative best-corrected visual acuity (BCVA) and the best postoperative BCVA during follow-up were collected. EZ width was measured on preoperative cross-sectional optical coherence tomography images along the horizontal/vertical meridian through the fovea. Results Thirty-eight eyes of 38 patients (22 female; mean [±standard deviation] age, 62.1 ± 11.8 years) were included. The median preoperative logarithm of the minimum angle of resolution BCVA of 0.52 (range, 0.00–3.00) significantly improved to 0.07 (range, −0.18–3.00) after surgery (P < 0.001). On preoperative spectral-domain optical coherence tomography images, the median horizontal, vertical, and average EZ widths were 783 (range, 0–9837), 761 (range, 0–10 250), and 769 (range, 0–10 043) μm, respectively. Postoperative BCVA significantly correlated with the horizontal (r = −0.784, P < 0.001), vertical (r = −0.777, P < 0.001), and average EZ widths (r = −0.777, P < 0.001). The area under the receiver operating characteristic curve for the ability of the horizontal, vertical, and average EZ widths to discriminate eyes with and without postoperative BCVA ≤ 0.3 was 0.971, 0.960, and 0.963, respectively, with best cut-off values of 513, 608, and 515 μm, respectively. Conclusions EZ width measurement can help predict the visual prognosis of cataract surgery in patients with retinitis pigmentosa. A preferable visual acuity prognosis can be expected in patients with an EZ width of approximately 600 μm.

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Association of retinal biomarkers and choroidal vascularity index on optical coherence tomography using binarization method in retinitis pigmentosa

Cited by 11 publications

References 33 publications

Associations Between the Choroidal Vascularity Index and Malignant Glaucoma After Trabeculectomy for Primary Angle Closure Glaucoma

Associations Between the Choroidal Vascularity Index and Malignant Glaucoma After Trabeculectomy for Primary Angle Closure Glaucoma

Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula

Use of ellipsoid zone width for predicting visual prognosis after cataract surgery in patients with retinitis pigmentosa

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