Association of rs670 variant of APOA-1 gene with cardiometabolic markers after consuming sesame, canola and sesame-canola oils in adults with and without type 2 diabetes mellitus

Ramezani‐Jolfaie, Nahid; Aghaei, Shiva; Yazd, Ehsan Farashahi; Mozaffari‐Khosravi, Hassan; Zimorovat, Alireza; Raeisi‐Dehkordi, Hamidreza; Moghtaderi, Fatemeh; Amiri, Mojgan; Ardakani, Seyed Ali Yasini; Salehi‐Abargouei, Amin

doi:10.1016/j.clnesp.2020.05.016

Cited by 7 publications

(4 citation statements)

References 30 publications

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“…29 The results of our parent project 30 on other health-related aspects have been reported elsewhere. 29,[31][32][33] Because the metabolic responses to dietary interventions may differ between healthy individuals and those with chronic diseases, we examined the effects of dietary CO, SO and SCO on body weight and composition, which were assessed as secondary outcomes in a large controlled clinical trial conducted in patients with T2DM. In addition, although sex-specific effects are well acknowledged in some area of research, 34 they are not sufficiently elucidated in nutrition research studies.…”

Section: Introductionmentioning

confidence: 99%

Effects of sesame, canola and sesame‐canola oils on body weight and composition in adults with type 2 diabetes mellitus: a randomized, triple‐blind, cross‐over clinical trial

et al. 2021

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BACKGROUND: Recent investigations have proposed that sesame and canola oils might affect body fat distribution. The present study aimed to examine the effects of sesame, canola and sesame-canola (a blend of sesame and canola oils) oils on body weight and composition in adults with type 2 diabetes mellitus in the context of a randomized, triple-blind, three-way, cross-over clinical trial.RESULTS: Eligible participants were randomized to replace their regular dietary oil with sesame oil (SO), canola oil (CO) and sesame-canola oil (SCO) (with 40% SO and 60% CO). Treatment periods lasted 9 weeks and were separated by 4-week washout periods. Body weight and composition were measured at the beginning, in the middle and at the end of each intervention phase. In total, 93 participants completed the study. After adjustment for confounders, within-period changes were observed following SO and CO intake for body weight (0.34 ± 0.16 kg and 0.33 ± 0.17 kg) and visceral fat (0.13 ± 0.06% and 0.13 ± 0.05%, P < 0.05), respectively. Body mass index was increased within SO intake (0.13 ± 0.05 kg m −2 , P = 0.031). All of the treatment oils resulted in reduced waist circumference and index of central obesity (P < 0.05). A significant difference in change values was observed for visceral fat between SCO (−0.14 ± 0.07%) and SO (0.12 ± 0.08%) treatment periods in females (P = 0.02).CONCLUSION: Sesame and canola oils might lead to a modest favorable body fat redistribution by reducing central adiposity, particularly in females; however, the changes were of little clinical importance.

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Section: Introductionmentioning

confidence: 99%

Effects of sesame, canola and sesame‐canola oils on body weight and composition in adults with type 2 diabetes mellitus: a randomized, triple‐blind, cross‐over clinical trial

et al. 2021

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“…48 Sesamin and episesamin have potent anti-dyslipidemic effects by blocking SREBP-1, SREBP-2, and HMG-CoA reductase and activating PPAR-α. 38 Sesame oil reduces oxidative damage and inhibits MAPK activation to modify cardiac RAS to alleviate LVH. 39 Through a rise in cyclic nucleotides (i.e., cAMP) and inhibition of MAPK phosphorylation, sesamol has significant antiplatelet action.…”

Section: Discussionmentioning

confidence: 99%

“…The result showed no significant differences in TC, triglycerides, LDL-C, HDL-C, apo A, apo B, or lipoprotein (a); however, significant differences were observed in LDL: HDL and TC:HDL ratios, blood pressure, as well as cardiovascular risk scores. 38 A study was conducted on a hypertensive animal model induced with cardiac hypertrophy using an injection of deoxycorticosterone and 1% sodium chloride. Sesame oil showed significant reduction in the size of cardiomyocytes, cardiac renin, angiotensin-converting enzyme, and angiotensin-II, and downregulated the expression of angiotensin receptor type-1, p38 MAPK, and JNK.…”

Section: Cardiovascular Diseases and Sesame Oilmentioning

confidence: 99%

A Comprehensive Review on Applicability and Bioactivity of Rogan-I-Kunjad (Sesamum indicum L-Oil): Unani Prospective

Naseem,

Khan,

Uddin

et al. 2023

ANAMS

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Sesame oil has a long history of usage as a food and medicine. It is the most used oil as a medicine or as a base oil for preparations of many compound drugs in the Unani system of medicine. It has a wide range of biological activities as mentioned in Unani classical text; this review highlights its pharmacological activities and their possible mode of action. Searched many Unani classical literature online and offline and simultaneously did parallel search on databases like PubMed, and Science Direct, and extraction of data related to sesame oil, sesame seeds with its pharmacological activities, mode of action, then interpretation and summarization of all related data. Sesame oil possesses many biological activities like anti-inflammatory, antihyperlipidemic, antiatherosclerotic, hepatoprotective, antiasthmatic, analgesic, emollient, antipruritic, and wound healing effects, which were scientifically demonstrated as mentioned in Unani literature. Sesame oil has a hopeful effect on modulating diseases with no significant toxic effect; so, there is a need to identify its safety and efficacy on human subjects to develop a new potential drug.

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“…Although, it is reported that MUFAs beneficially affect Apo A‐1, but no significant effect of CO on this marker was indicated (Negele et al, 2015). It should be noted that some genetic polymorphisms might interact with dietary oils in their effect on cardiometabolic markers (Ramezani‐Jolfaie et al, 2020a; Ramezani‐Jolfaie et al, 2020b).…”

Section: Discussionmentioning

confidence: 99%

The effect of sesame, canola, and sesame‐canola oils on cardiometabolic risk factors in overweight adults: a three‐way randomized triple‐blind crossover clinical trial

Moghtaderi

Amiri

Raeisi‐Dehkordi

et al. 2022

Phytotherapy Research

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Limited data exist on the cardiometabolic effects of sesame oil compared with canola oil. In the present study, 77 overweight adults were randomized to replace their regularly consumed oils with canola (CO), sesame (SO), and sesame‐canola oils (SCO, 40% SO, and 60% CO) in three 9‐week phases. Blood pressure, visceral adiposity index, serum apo‐proteins (APOs) and lipid profile, glycemic control markers, kidney markers, liver enzymes, and cardiovascular disease risk scores were assessed at baseline and endline. After adjustment for confounders, SO significantly reduced serum alkaline aminotransferase (ALT) compared to CO (p ≤ 0.05) in all participants, increased serum urea compared to SCO in males, and decreased serum alkaline phosphatase compared to other oils in males, and improved serum high‐density lipoprotein cholesterol (HDL‐C) and triglycerides (TG) compared to SCO, and eGFR compared with CO in females (p ≤ 0.05). Canola oil significantly improved serum Apo A1 and APO B/A ratio compared with SO, in males (p ≤ 0.05). Sesame‐canola oil significantly reduced serum urea compared to other oils in all participants (p ≤ 0.05). Sesame oil and SCO might beneficially affect serum ALT and urea, respectively. Intervention oils might have different cardiometabolic effects in each gender. Further studies are needed to confirm our results (Trial registration code: IRCT2016091312571N6).

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Association of rs670 variant of APOA-1 gene with cardiometabolic markers after consuming sesame, canola and sesame-canola oils in adults with and without type 2 diabetes mellitus

Cited by 7 publications

References 30 publications

Effects of sesame, canola and sesame‐canola oils on body weight and composition in adults with type 2 diabetes mellitus: a randomized, triple‐blind, cross‐over clinical trial

Effects of sesame, canola and sesame‐canola oils on body weight and composition in adults with type 2 diabetes mellitus: a randomized, triple‐blind, cross‐over clinical trial

A Comprehensive Review on Applicability and Bioactivity of Rogan-I-Kunjad (Sesamum indicum L-Oil): Unani Prospective

The effect of sesame, canola, and sesame‐canola oils on cardiometabolic risk factors in overweight adults: a three‐way randomized triple‐blind crossover clinical trial

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