Association of selected gene polymorphisms with thermotolerance traits in cattle – A review

Abstract

Thermal stress due to extreme changes in the thermal environment is a critical issue in cattle production. Many previous findings have shown Many evidences showed a decrease in feed intake, milk yield, growth rate, and reproductive efficiency of the cattle when subjected to thermal stress. Therefore, sSelecting thermo-tolerant animals are is therefore the main primary goal of the efficiency of breeding programs to reduce those adverse impacts. The recent advances in molecular genetics have provided significant breeding advantages that allow the identification of molecular markers in both beef and dairy cattle breeding, including the use of marker-assisted selection (MAS) as a tool in selecting superior thermo-tolerant animals.Single-nucleotide polymorphisms (SNPs), which can be detected by DNA sequencing, are desirable DNA markers for MAS due to their abundance in the genome's both coding and noncoding regions of the genomes. MTill date, many SNPs in some genes (e.g., HSP70, HSP90, HSF1, EIF2AK4, HSBP1, HSPB8, HSPB7, MYO1A, and ATP1A1) in various breeds of cattle have been analyzed to play have key roles in many cellular activities during thermal stress and protecting cells against stress, thereby beingmaking them potential candidate genes for molecular markers of thermotolerance. TIn this review , we highlighted the associations of SNPs within these genes with thermotolerance traits (e.g., blood biochemistry and physiological responses), which could imply suggesting their potential use as MAS in thermotolerant cattle breeding.

Genome-wide expression analysis reveals different heat shock responses in indigenous (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle

“…Many of the genes identified in the present study were found related the heat tolerance traits of cattle in the previous studies [ 45 – 47 ]. Polymorphisms in different heat shock proteins ( HSP90 , HSPA6, HSPB7 ) and heat shock factor 1 ( HSF1 ) were associated with the heat tolerance traits in cattle [ 45 , 48 , 49 ]).…”

Gene polymorphism in a population of Charolais beef cattle using DNA-markers

“…towards practical aspects of genomic selection, the analysis of polymorphism of specifi c genes and their complexes, as a foundation of MAS strategy, still remains very profi table and essential (Colombi et al, 2024). Especially in combination with the study of new functional genes, such as myostatin (Kostusiak et al, 2023), pyruvate kinase L/R (Du et al, 2022), heat shock proteins (HSPs) (Hariyono et al, 2022), adiponectin (Fonseca et al, 2015;Pandey et al, 2020).…”

Recent Advances in Dairy Animal Breeding and Reproduction: A Review

“…Molecular marker-assisted introgression (MAI) is a breeding technique that utilizes molecular markers to identify and select desirable traits in dairy animals. This technique involves the identification of molecular markers linked to specific traits of interest, such as milk production or disease resistance, and the use of these markers to select animals with the desired traits for breeding (Hariyono et al, 2022). Those markers are used to help livestock breeders choose individuals who express the introgressed gene.…”

“…Additionally, MAI has been used to introgress desirable traits from wild or exotic breeds into domesticated dairy animals, resulting in improved performance and adaptation to changing environmental conditions for example, the use of molecular markers has been shown to be effective in selecting thermo-tolerant animals in dairy cattle breeding, allowing for the selection of superior thermo-tolerant animals through marker-assisted selection (MAS) (Hariyono et al, 2022).…”