Association of Serum Antioxidant Capacity with Coronary Artery Disease in Middle-aged Men.

Abstract

SUMMARYThe possible involvement of oxidative damage in the progression of atherosclerosis has been suggested. There is some evidence that antioxidant therapy may be beneficial for the prevention of coronary heart disease. In this study, we investigated the relationship between coronary artery disease (CAD) and serum antioxidative status by measuring the total antioxidant status (TAS). Other relevant antioxidants, such as retinol, α, γ-tocopherol, ascorbic acid, α, β-carotenoids, erythrocyte glutathione peroxidase (GSH-Px) and oxidative products, were also determined in 31 male CAD patients with angiographically defined CAD and 66 male controls, aged 40-70 years, in a case-control study. The TAS levels, ratio and the concentrations of retinol, albumin, total protein and HDL cholesterol were significantly lower in the CAD patients than in the controls (p<0.01), and α-tocopherol andα/γ-tocopherol were significantly higher in the CAD patients than in the controls. The TAS level correlated positively withγ-GTP, GPT, GOT and uric acid (p<0.01). A multiple regression analysis in the CAD patients revealed that the TAS levels correlated most negatively with the number of diseased vessels. The concentrations of carotenoids and GSH-Px, as well as the α/γ-tocopherol ratio were also significantly associated. Although conditional logistic regression analysis suggested low levels of HDL-cholesterol to be a significant coronary risk factor (OR=5.1, 95% CI=1.09-24.3), the TAS level showed no significant independent contribution to CAD. This study demonstrated an association of antioxidant parameters with the atherosclerosis progression, however, it did not confirm antioxidants as an independent risk factor for CAD event. (Jpn Heart J 2001; 42: 677-690)

Carotid intima-media thickness and paraoxonase activity in patients with ankylosing spondylitis

“…As mentioned previously, the PON1 ezyme exhibits signi cant anti-oxidant properties and plays an important role in preventing LDL oxidation. Taken together, these observations mean that the PON1 enzyme acts primarily as an antioxidant, especially preventing LDL oxidation, and hence seems to play a preventative role in atherogenesis [30,31].…”

Relationship between total antioxidant capacity and the severity of coronary artery disease

“…Also, the slight decrease in TOS and OSI was observed in the three-VD category but this difference was not statistically significant (6.7±3. 4 in the pathogenesis of atherosclerosis. 16 There are encouraging correlation between DNA oxidation and TAC in smokers, however plasma TAC in smokers imprecisely higher than nonsmokers.…”

“…2,3 Oxidants were increased and antioxidants were decreased, and because of these, oxidative/antioxidative balance shifted to oxidative side in patients with coronary artery disease (CAD). 4 Antioxidants have been hypothesized to inhibit lipid peroxidation and therefore may play a protective role in the development of cardiovascular disease by preventing the formation of early atherosclerotic lesions. 5 Plasma concentrations of antioxidants can be measured separately in laboratory, but these measurements are time-consuming, labor-intensive, and costly.…”

Synergistic Effect of Galantamine Carried on a Novel Nano-Drug Delivery System on Induced Lung Disorders in Alzheimer’s Disease

“…[32] Increase in TGF-β levels could be used as a reliable biomarker for pulmonary disorders especially fibrosis. [33,34,35] TGF-β1 is the major profibrotic growth factor which stimulates fibroblast collagen production and deposition. As a result of previous studies, TGF-β1 is believed to be a high mediator of fibrotic, and remodeling responses in the lung and other organs, and these responses are believed to be mediated by the ability of TGF-β1 to activate fibrogenic and apoptotic "injury" pathways.…”

“…[3,14,15] There is an inverse association between TAC and the number of damaged vessels in brain or other tissues. [35] Also, reports by [15] stated that the oxidant production due to chronic inflammation, as evidenced by the increased (oxidative stress index) OSI levels and decreased level of TAC might contribute to persistent lung injury. As oxidative stress is a significant element in AD pathogenesis thus attenuated protection against ROS production in elder patients might trigger and add to the onset of AD and its progression.…”