Association of serum fetuin-A levels with heart valve calcification and other biomarkers of inflammation among persons with acute coronary syndrome

Abstract

Association of serum fetuin-A levels with heart valve calci cation and other biomarkers of in ammation among persons with acute coronary syndrome Abstract Purpose: Fetuin-A is a multifunctional hepatic secretory protein that inhibits dystrophic vascular and valvular calci cation. Our aim was to evaluate the relationship among fetuin-A levels, heart valve calci cation and other biomarkers of in ammation in patients with acute coronary syndrome (ACS).Methods: e associations among serum fetuin-A concentrations, mitral annular (MAC) and aortic valve calci cation and other biomarkers of in ammation (hs-CRP, ferritin, -brinogen, white blood cell count (WBC), erythrocyte sedimentation rate (ESR), albumin levels) were evaluated in ACS patients and healthy controls. e study included 95 patients (mean age 61.8±12.10 years) and 81 healthy controls (mean age 48.33±9.19 years).Results: Fetuin-A levels were signi cantly lower in patients with ACS than in healthy controls (0.76 ± 0.23 and 1.10 ± 0.45 g/L, respectively; p<0.001). Fetuin-A was lower in patients with mitral annular calci cation (p=0.007) and aortic (p=0.001) valve calci cation. In patients with ACS, there was a negative correlation among serum urea (r=-0.377; p<0.001) and creatinine (r=-0.232; p=0.024) levels and fetuin-A, and a negative correlation among WBC (r=-0.156; p=0,132), ESR (r=-0.214; p=0.037), hs-CRP (r=-0.220; p=0.032) levels and fetuin-A. A positive correlation was seen between albumin and fetuin-A (r=0.362; p<0.001). Multivariate logistic regression analysis revealed that fetuin-A was the variable that had a signi cant e ect on ACS (p = 0.020 OR = .015; (95% CI )(0.000-0.520).Conclusion: Fetuin-A levels decrease in patients with acute coronary syndromes, independent of heart valve calci cation. Fetuin-A may therefore act as a negative acute phase protein a er myocardial infarction.

Serum Fetuin-A Levels in Patients with Cardiovascular Disease: A Meta-Analysis

“…Moreover, Mori et al have shown that lower serum levels of FA are correlated with the disease [34]. Lower serum levels of FA could promote inflammatory processes and the production of cardiotoxic TNF, resulting in left ventricle remodeling and acute coronary syndrome relapse [24]. Based on the above facts, we can conclude that lower serum levels of FA play an important role in the development of CVDs because of the function of FA in systemic calcification and inflammatory process.…”

Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions

“…Furthermore, decreased serum fetuin-A and albumin levels are associated with the development of coronary artery disease and heart valve calcification505152535455565758. Therefore, the risk factors of atherosclerosis and heart valve calcification are identical to those promoting the formation of CPB in the human blood.…”

Fetuin‐A, a new vascular biomarker of cognitive decline in older adults

“…Fetuin‐A is a negative acute‐phase reactant capable of attenuating inflammatory responses to injury and infection . At higher concentrations, fetuin‐A suppresses the release of tumour necrosis factor (TNF) from lipopolysaccharide (LPS)‐stimulated macrophages, and plasma levels of fetuin‐A are negatively correlated with levels of CRP in dialysis patients and in patients with acute coronary syndrome . Of importance to the present study, peripheral administration of fetuin‐A has been shown to protect against early brain ischaemic injury in a rodent model, possibly by attenuating the brain inflammatory response .…”