Association of Serum Klotho with Loss of Bone Mineral Density and Fracture Risk in Older Adults

Chalhoub, Didier; Marques, Elisa A.; Meirelles, Osorio; Semba, Richard D.; Ferrucci, Luigi; Satterfield, Suzanne; Nevitt, Michael C.; Cauley, Jane A.; Harris, Tamara B.

doi:10.1111/jgs.14661

Cited by 30 publications

(15 citation statements)

References 19 publications

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“…Nevertheless, more research is needed because until now, only a few cross-sectional studies have investigated the association of FGF23 with BMD in apparently healthy participants, providing controversial results [ 59 , 60 , 61 , 62 ]. Furthermore, until now, only a few epidemiological studies [ 60 , 63 , 64 ] have investigated the associations between circulating α-klotho and bone health and showed conflicting results.…”

Section: Discussionmentioning

confidence: 99%

Vegan Diet and Bone Health—Results from the Cross-Sectional RBVD Study

et al. 2021

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Scientific evidence suggests that a vegan diet might be associated with impaired bone health. Therefore, a cross-sectional study (n = 36 vegans, n = 36 omnivores) was used to investigate the associations of veganism with calcaneal quantitative ultrasound (QUS) measurements, along with the investigation of differences in the concentrations of nutrition- and bone-related biomarkers between vegans and omnivores. This study revealed lower levels in the QUS parameters in vegans compared to omnivores, e.g., broadband ultrasound attenuation (vegans: 111.8 ± 10.7 dB/MHz, omnivores: 118.0 ± 10.8 dB/MHz, p = 0.02). Vegans had lower levels of vitamin A, B2, lysine, zinc, selenoprotein P, n-3 fatty acids, urinary iodine, and calcium levels, while the concentrations of vitamin K1, folate, and glutamine were higher in vegans compared to omnivores. Applying a reduced rank regression, 12 out of the 28 biomarkers were identified to contribute most to bone health, i.e., lysine, urinary iodine, thyroid-stimulating hormone, selenoprotein P, vitamin A, leucine, α-klotho, n-3 fatty acids, urinary calcium/magnesium, vitamin B6, and FGF23. All QUS parameters increased across the tertiles of the pattern score. The study provides evidence of lower bone health in vegans compared to omnivores, additionally revealing a combination of nutrition-related biomarkers, which may contribute to bone health. Further studies are needed to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Vegan Diet and Bone Health—Results from the Cross-Sectional RBVD Study

et al. 2021

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“…In the CKD patients, Klotho protein did not correlate with bone density. Chalhoub et al showed no correlation between Klotho, BMD and the risk of bone fracture [31]. Yaghoubi et al showed no significant correlation between FGF23, BMI and lipid profile [32].…”

Section: Discussionmentioning

confidence: 99%

Association Between Plasma Concentration of Klotho Protein, Osteocalcin, Leptin, Adiponectin, and Bone Mineral Density in Patients with Chronic Kidney Disease

et al. 2018

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Patients with early-stage chronic kidney disease (CKD) are susceptible to changes in metabolic processes. Partial loss of kidney function leads to homoeostatic disturbances in bone and fatty tissue. The aim of this study was to investigate the association between plasma concentrations of Klotho protein, FGF23, leptin, adiponectin, osteocalcin, and bone mineral density (BMD) in patients with CKD in the pre-dialysis period. The study involved 52 patients with CKD and 23 patients with no kidney disease. In both groups, BMD, body mass index and serum or plasma concentrations of lipids, glucose, creatinine, calcium, phosphorus, parathormone, leptin, adiponectin, osteocalcin, Klotho, and FGF23 were measured. The group with CKD had statistically significant higher concentrations of leptin (p<0.001), parathormone (p<0.001), and osteocalcin (p<0.001) in comparison with the control group. Patients with CKD also had statistically significant lower BMD in the femoral neck in comparison with the control group. Osteocalcin correlated negatively with BMD. The results of our study suggest that elevated osteocalcin is the most sensitive marker of decreased bone mass in patients with CKD. Osteocalcin correlated negatively with BMD and GFR. The loss of bone mass in CKD patients was greatest in the femoral neck.

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“…Finally, given the central role of klotho in calcium/ phosphate balance and in bone remodelling, the regular intake of calcium and cholecalciferol in 20 osteoporotic patients and the lack of a control group could have added further bias to our analysis, although no significant association was recorded between serum klotho concentration and the odds of having osteoporosis in the SSc cohort. Moreover, a recent work by Chalhoub et al failed to assign sufficient relevance to soluble klotho as a biomarker of bone resorption and fracture risk (25). …”

Section: Original Papermentioning

confidence: 99%

The role of klotho in systemic sclerosis

Talotta¹,

Bongiovanni²,

Letizia³

et al. 2017

Reumatismo

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The aim was to evaluate the role of klotho in the pathogenesis of systemic sclerosis (SSc), through the measurement of its serum concentration in SSc patients compared to healthy controls, and to assess the association with cutaneous and visceral involvement. Blood samples obtained from both SSc patients and healthy controls were analysed by an ELISA assay for the detection of human klotho. SSc patients were globally evaluated for disease activity and assessed through the modified Rodnan’s Skin Score, Medsger’s scale, pulmonary function tests, 2D-echocardiography, nailfold capillaroscopy and laboratory tests. Our cohort consisted of 69 SSc patients (61 females, mean age 64.5±12.5 years, median disease duration 9.0 (IQR 8) years) and 77 healthy controls (28 females, mean age 49.7±10.2 years). In the group of SSc patients, 19 (27.5%) suffered from a diffuse form of SSc. All patients were receiving IV prostanoids, and some of them were concomitantly treated with immunosuppressive drugs (prednisone, hydroxychloroquine, mofetil mycophenolate, methotrexate, cyclosporin A and azathioprine). The median serum concentration of klotho was significantly lower in patients compared to controls (0.23 ng/mL vs 0.60 ng/mL; p<0.001). However, Spearman’s test showed no significant association between klotho serum levels and disease activity, concerning either clinical, laboratory or instrumental findings. Our data show a significant deficit of klotho in SSc patients although any significant association was detected between klotho serum concentration and the clinical, laboratory or instrumental features of the disease. However, due to the limits of the study, further investigations are required.

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Association of Serum Klotho with Loss of Bone Mineral Density and Fracture Risk in Older Adults

Cited by 30 publications

References 19 publications

Vegan Diet and Bone Health—Results from the Cross-Sectional RBVD Study

Vegan Diet and Bone Health—Results from the Cross-Sectional RBVD Study

Association Between Plasma Concentration of Klotho Protein, Osteocalcin, Leptin, Adiponectin, and Bone Mineral Density in Patients with Chronic Kidney Disease

The role of klotho in systemic sclerosis

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