Association of serum lipoprotein(a) concentration with other cardiovascular risk factors in a chinese population

Abstract

The association between serum Lp(a) concentration, a risk factor for atherothrombotic disease, and other cardiovascular risk factors such as smoking, alcohol intake, hypertension, obesity, and indices of glycemic control is examined in a cohort of 313 elderly Chinese subjects (M = 160, mean age +/- SD = 68 +/- 11 year; F = 153, mean age +/- SD = 73 +/- 11). Although associations existed for the above risk factors and other serum lipid levels, there was no association with serum Lp(a) concentration in the overall population. Men with Lp(a) greater than or equal to 30 mg/dl had a higher mean age and blood pressure. A higher percentage of subjects with Lp(a) greater than or equal to 30 mg/dl had a family history of stroke, although the total number of those with a family history was too small to reach statistical significance. The lack of association with known modifiable cardiovascular risk factors is compatible with the conclusion that Lp(a) concentration is primarily under genetic control and therefore unlikely to be a modifiable risk factor.

Lipoprotein (a) level in the population in Taiwan: relationship to sociodemographic and atherosclerotic risk factors

“…The range of Lp(a) levels for this study population seemed similar to that for the Framingham offspring [7], and significantly lower than that for Japanese and black populations [23,24]. A limited number of studies have reported the median values of Lp(a) for other Chinese ethnic groups, ranging from 7.0 mg/dl for Chinese in Singapore to 25.0 mg/dl for Chinese in Hong Kong [3,12]. However, those measures were based on small sample sizes between 30 and 304.…”

“…However, most studies are hospital-based or employee-based [11] and limited data are available for Asian populations. Only a few studies on Chinese ethnic groups are available and have provided inconsistent data on Lp(a) due to small sample size [12,13].…”

Role of lipoprotein (A) as a Nonconventional Risk Factor in Patients of Acute Myocardial Infarction in Tertiary Centre of North India

“…Lp(a) excess accelerates the risk of premature CAD. Numerous studies in several continents within the past decade confirm and extend the previous evidence that Lp(a) is one of the top seven major risk factor for cardiovascular diseases [7][8][9][10][11][12][13][14][15][16][17] .…”

The Relationship Between Serum Lipoprotein(a) and Insulinemia in Healthy Nondiabetic Adult Men

“…Lp(a) concentrations were weakly correlated positively with BMI among 186 subjects with 1DDM (13). Furthermore, in several studies, Lp(a) concentrations and BMI or other indexes of upper body obesity were unrelated (41)(42)(43). These conflicting results could be related to the complex interactions between obesity, physical activity, insulinemia, and sex hormone levels.…”