Association of Serum Phosphate Levels and Anemia in Critically Ill Surgical Patients

Otero, Tiffany M. N.; Canales, Cecilia; Yeh, D. Dante; Johnson, Emily; Harrison, Tara M.; Belcher, Donna; Quraishi, Sadeq A.

doi:10.1177/0148607115626415

Cited by 4 publications

(4 citation statements)

References 39 publications

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“…However, these patients also had shorter durations of mechanical ventilation, which is contrary to the results from the study by Suzuki et al Excessive phosphate may simply be a surrogate for severe cell death in the setting of ongoing septic shock, but direct toxicity from hyperphosphatemia is also possible. Although the data in critically ill humans are limited, possible mechanisms include vascular inflammation, 16 reactive oxygen species caused by disrupted mitochondrial function, 17 anemia, 18 and exacerbation of ischemia and cardiovascular disease caused by a high calcium:phosphate product. [19][20][21] The current study does possess some limitations.…”

Section: Discussionmentioning

confidence: 99%

Impact of Serum Phosphate in Mechanically Ventilated Patients With Severe Sepsis and Septic Shock

Miller

Doepker

Springer

et al. 2018

J Intensive Care Med

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Time-weighted hyperphosphatemia may be associated with increased mortality in mechanically ventilated patients with severe sepsis or septic shock. However, time-weighted hypo- and hyperphosphatemia were associated with decreased duration of mechanical ventilation. Future studies should further describe the impact of hypo- and hyperphosphatemia on clinical outcomes among critically ill patients with severe sepsis or septic shock.

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Section: Discussionmentioning

confidence: 99%

Impact of Serum Phosphate in Mechanically Ventilated Patients With Severe Sepsis and Septic Shock

Miller

Doepker

Springer

et al. 2018

J Intensive Care Med

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“…Lack of erythropoietin synthesis, inhibition of erythropoietin in bone marrow by cytokine overproduction [ 137 , 138 ] and bone marrow reduced sensitivity to erythropoietin under inflammatory conditions [ 137 , 138 ] can explain patient anemia. Of note, angiotensin II is now considered a cytokine that regulates inflammation and fibrosis [ 139 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of a Metabolic Mixture on Gut Inflammation and Permeability in Elderly Patients with Chronic Kidney Disease: A Proof-of-Concept Study

et al. 2022

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Intestinal barrier dysfunction is a risk factor for the progression of Chronic Kidney Disease (CKD). In this proof-of-concept study, we tested the effects of a mixture of Essential Amino Acids (EAAs) and mitochondrial substrates on intestinal inflammation and permeability of CKD patients. Eight patients with stage 3b-4 CKD and 11 healthy controls after overnight fasting underwent fecal measures of calprotectin and zonulin levels (indicators of gut inflammation and permeability, respectively) and determinations of plasma amino acids. Only CKD patients were supplemented with the mixture (8 g/d diluted in water). Compared to controls, baseline fecal calprotectin, zonulin and plasma levels of some AA in CKD patients were significantly higher (p = 0.005; p = 0.001 and p = 0.02 to 0.003, respectively). After six months of supplementation, CKD baseline fecal levels of calprotectin and zonulin significantly (borderline for zonulin) decreased (p = 0.008 and p = 0.05, respectively). Plasma AA concentrations, including glutamine and alanine, were higher than at the baseline (p: 0.05 to 0.008). The supplementation of this mixture was associated with improved intestinal barrier dysfunction. Increased plasma AA levels might contribute to the improvement of gut barrier dysfunction.

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“…Septik şoktaki hastalarda hiperfosfatemi hücre ölümüne neden olabilir fakat hiperfosfateminin direkt toksisitesi daha da muhtemeldir [15] . Fakat YBÜ'de yatan hastalar için bu bilgi sınırlıdır, vasküler inflamasyon, mitokondrial disfonksiyon nedenli oluşan reaktif oksijen türleri, anemi, iskemi artışı ve yüksek kalsiyum nedenli kardiyovasküler hastalıkları içeren çeşitli nedenler fosfat üretimine neden olabilir [19][20][21][22] .…”

Section: Discussionunclassified

The Effects of Serum Phosphate on 28-day Mortality in Patients Hospitalized in the Intensive Care Unit, Treated with Mechanical Ventilator Therapy and Treated with CRRT for Septic Shock-Induced Acute Kidney Injury

Kaçar¹,

Uzundere²,

Kandemir³

et al. 2020

GKDA

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Fosfat sinyal iletimini, enerji üretimini ve mineral metabolizmasını içeren düzenleyici çoklu metabolik olayda yer alan esansiyel bir mineraldir. Biz bu çalışmada hastaların serum fosfat düzeylerinin fosfat referans değeri olarak verilen 2,5-4,5 mg/dL alt ve üst sınırlarından sapmasının 28 günlük mortalite üzerine etkisini araştırmayı planladık. Yöntem: Hastanemiz başhekimliğinden yazılı izin alındıktan sonra hasta dosyaları retrospektif olarak taranarak yoğun bakım ünitemizde yatan septik şok ilişkili akut böbrek hasarı nedenli sürekli renal replasman tedavisi gören ve 18 yaş üstü 53 adet hasta çalışmaya dahil edildi. Hastanemiz biokimya laboratuarındaki serum fosfat düzeyi referans arlığı 2,5-4,5 mg/dL olduğundan hastaların ortalama serum fosfat düzeylerinin alt sınır referans aralığı olan 2,5 mg/dL ve üst sınır referans aralığı olan 4,5 mg/dL'ye göre istatistiksel değişimleri hesaplandı.

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Association of Serum Phosphate Levels and Anemia in Critically Ill Surgical Patients

Cited by 4 publications

References 39 publications

Impact of Serum Phosphate in Mechanically Ventilated Patients With Severe Sepsis and Septic Shock

Impact of Serum Phosphate in Mechanically Ventilated Patients With Severe Sepsis and Septic Shock

Effects of a Metabolic Mixture on Gut Inflammation and Permeability in Elderly Patients with Chronic Kidney Disease: A Proof-of-Concept Study

The Effects of Serum Phosphate on 28-day Mortality in Patients Hospitalized in the Intensive Care Unit, Treated with Mechanical Ventilator Therapy and Treated with CRRT for Septic Shock-Induced Acute Kidney Injury

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