Association of serum selenium with thyroxin in severely iodine-deficient young children from the Amhara region of Ethiopia

Gashu, Dawd; Stoecker, Barbara J.; Adish, Abdulaziz; Haki, Gulelat Desse; Bougma, Karim; Aboud, Frances E.; Marquis, Grace S

doi:10.1038/ejcn.2016.27

Cited by 26 publications

(37 citation statements)

References 30 publications

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“…Today's World. 2017 Feb; 6 (2): 21-26 agreement with a recent study that low selenium level associated with higher concentration of plasma T4 (13,21). In several studies in Iran (12,22,23), Turkey (24,25) and Poland (26), goitrous patients had significant lower Selenium levels than nongoitrous ones.…”

Section: J Biol Today's World 2017 Feb; 6 (2): 21-26 Figure 1 Spesupporting

confidence: 74%

“…The result of another study in central part of our country revealed that the prevalence of Selenium deficiency in goitrous children was 75.0% and their serum selenium level was 66.86±21.82 (12). In study from Ethiopia, highly selenium deficiency was found in children from the western part of the country but the children in eastern part had little or no selenium deficiency (13). Similar to these studies, the frequency of selenium deficiency and toxicity in china was highly variable in populations of just 20 km apart (14).…”

Section: J Biol Today's World 2017 Feb; 6 (2): 21-26 Figure 1 Spementioning

confidence: 99%

“…Since the selenium level of the population is determined mainly by the food they consume. These variable distributions attributed to the selenium level in the soil, which varies by the geochemical characteristic (13). Based on several studies, there is a complex association between trace element selenium and thyroid hormone metabolism (15)(16)(17).…”

Section: J Biol Today's World 2017 Feb; 6 (2): 21-26 Figure 1 Spementioning

confidence: 99%

See 2 more Smart Citations

Assessment of the Selenium Status in Hypothyroid Children from North East of Iran

Khorasani¹,

Mirhafez²,

Niroumand³

2017

J.JBTW

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Section: J Biol Today's World 2017 Feb; 6 (2): 21-26 Figure 1 Spesupporting

confidence: 74%

Section: J Biol Today's World 2017 Feb; 6 (2): 21-26 Figure 1 Spementioning

confidence: 99%

Section: J Biol Today's World 2017 Feb; 6 (2): 21-26 Figure 1 Spementioning

confidence: 99%

See 1 more Smart Citation

Assessment of the Selenium Status in Hypothyroid Children from North East of Iran

Khorasani¹,

Mirhafez²,

Niroumand³

2017

J.JBTW

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“…Gashu et al . [53] reported Se deficiency risk in school children in the Amhara region of Ethiopia to be 58% (n = 349).…”

Section: Discussionmentioning

confidence: 99%

Variation in the mineral element concentration of Moringa oleifera Lam. and M. stenopetala (Bak. f.) Cuf.: Role in human nutrition

et al. 2017

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BackgroundMoringa oleifera (MO) and M. stenopetala (MS) (family Moringaceae; order Brassicales) are multipurpose tree/shrub species. They thrive under marginal environmental conditions and produce nutritious edible parts. The aim of this study was to determine the mineral composition of different parts of MO and MS growing in their natural environments and their potential role in alleviating human mineral micronutrient deficiencies (MND) in sub-Saharan Africa.MethodsEdible parts of MO (n = 146) and MS (n = 50), co-occurring cereals/vegetables and soils (n = 95) underneath their canopy were sampled from localities in southern Ethiopia and Kenya. The concentrations of seven mineral elements, namely, calcium (Ca), copper (Cu), iodine (I), iron (Fe), magnesium (Mg), selenium (Se), and zinc (Zn) in edible parts and soils were determined using inductively coupled plasma-mass spectrometry.ResultsIn Ethiopian crops, MS leaves contained the highest median concentrations of all elements except Cu and Zn, which were greater in Enset (a.k.a., false banana). In Kenya, Mo flowers and MS leaves had the highest median Se concentration of 1.56 mg kg-1 and 3.96 mg kg-1, respectively. The median concentration of Se in MS leaves was 7-fold, 10-fold, 23-fold, 117-fold and 147-fold more than that in brassica leaves, amaranth leaves, baobab fruits, sorghum grain and maize grain, respectively. The median Se concentration was 78-fold and 98-fold greater in MO seeds than in sorghum and maize grain, respectively. There was a strong relationship between soil total Se and potassium dihydrogen phosphate (KH2PO4)-extractable Se, and Se concentration in the leaves of MO and MS.ConclusionThis study confirms previous studies that Moringa is a good source of several of the measured mineral nutrients, and it includes the first wide assessment of Se and I concentrations in edible parts of MO and MS grown in various localities. Increasing the consumption of MO and MS, especially the leaves as a fresh vegetable or in powdered form, could reduce the prevalence of MNDs, most notably Se deficiency.

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“…Neurocognitive and motor impairments observed in konzo, a motor neuron disease associated with cassava cyanogenic exposure in nutritionally challenged African children, may possibly be driven by the combined effects of cyanide toxicity and selenium deficiency (Bumoko et al, 2015). Selenium and a number of other trace elements may also influence goiter development and general thyroid metabolism (Kishosha et al, 2011;Maouche et al, 2015;El-Fadeli et al, 2016;Gashu et al, 2016). Liver function may be compromised in nickel-plating workers (El-Shafei, 2011).…”

Section: Health Outcomesmentioning

confidence: 99%

Environmental Health Research in Africa: Important Progress and Promising Opportunities

Joubert

Mantooth²,

McAllister

2020

Front. Genet.

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The World Health Organization in 2016 estimated that over 20% of the global disease burden and deaths were attributed to modifiable environmental factors. However, data clearly characterizing the impact of environmental exposures and health endpoints in African populations is limited. To describe recent progress and identify important research gaps, we reviewed literature on environmental health research in African populations over the last decade, as well as research incorporating both genomic and environmental factors. We queried PubMed for peer-reviewed research articles, reviews, or books examining environmental exposures and health outcomes in human populations in Africa. Searches utilized medical subheading (MeSH) terms for environmental exposure categories listed in the March 2018 US National Report on Human Exposure to Environmental Chemicals, which includes chemicals with worldwide distributions. Our search strategy retrieved 540 relevant publications, with studies evaluating health impacts of ambient air pollution (n=105), indoor air pollution (n = 166), heavy metals (n = 130), pesticides (n = 95), dietary mold (n = 61), indoor mold (n = 9), per-and polyfluoroalkyl substances (PFASs, n = 0), electronic waste (n = 9), environmental phenols (n = 4), flame retardants (n = 8), and phthalates (n = 3), where publications could belong to more than one exposure category. Only 23 publications characterized both environmental and genomic risk factors. Cardiovascular and respiratory health endpoints impacted by air pollution were comparable to observations in other countries. Air pollution exposures unique to Africa and some other resource limited settings were dust and specific occupational exposures. Literature describing harmful health effects of metals, pesticides, and dietary mold represented a context unique to Africa. Studies of exposures to phthalates, PFASs, phenols, and flame retardants were very limited. These results underscore the need for further focus on current and emerging environmental and chemical health risks as well as better integration of genomic and environmental factors in African research studies. Environmental exposures with distinct routes of exposure, unique co-exposures and co-morbidities, combined with the extensive genomic diversity in Africa may lead to the identification of novel mechanisms underlying complex disease and promising potential for translation to global public health.

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Association of serum selenium with thyroxin in severely iodine-deficient young children from the Amhara region of Ethiopia

Abstract: Serum Se was negatively associated with T4 level in young children from the Amhara region of Ethiopia and may endanger the effectiveness of the salt iodization program.

Cited by 26 publications

References 30 publications

Assessment of the Selenium Status in Hypothyroid Children from North East of Iran

Assessment of the Selenium Status in Hypothyroid Children from North East of Iran

Variation in the mineral element concentration of Moringa oleifera Lam. and M. stenopetala (Bak. f.) Cuf.: Role in human nutrition

Environmental Health Research in Africa: Important Progress and Promising Opportunities

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