Association of Serum Uric Acid with cardio-metabolic risk factors and metabolic syndrome in seafarers working on tankers

Baygi, Fereshteh; Herttua, Kimmo; Sheidaei, Ali; Jensen, Olaf Chresten

doi:10.1186/s12889-020-08466-2

Cited by 10 publications

(10 citation statements)

References 45 publications

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“…Various studies (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) have reported a relationship between UA and MetS, supporting the findings of our study. Mahajan et al (7) reports that UA raises blood pressure levels through the stimulation of intracellular oxidative stress.…”

Section: Discussionsupporting

confidence: 91%

“…UA is formed by the liver, is excreted by kidneys with some production by the intestines (7). Hyperuricemia (above 7.0 mg/dL in men and 6.0 mg/dL in women) has been reported in previous studies (3)(4)(5)(6)(7) to be associated with many of the same biomarkers of MetS and diseases such as diabetes, CVD, and kidney disease. Many studies have suggested hyperuricemia is an established risk factor for MetS, (8-10) while others have not reported a relationship when comparing those with and without Diabetes Mellitus (DM) (11).…”

Section: Introductionmentioning

confidence: 80%

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Uric acid and metabolic syndrome: Findings from national health and nutrition examination survey

Bowden

Adair

Richardson³

2022

Front. Med.

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IntroductionHyperuricemia commonly associated with Gout has been proposed as an independent risk factor for Metabolic Syndrome (MetS).ObjectiveThe purpose of the study was to determine if there is a relationship between hyperuricemia and MetS.MethodsAn analysis of cross-sectional data was conducted using the 2013–2018 National Health and Nutrition Examination Survey (NHANES) datasets. Sample weights were assigned by NHANES researchers to each participant allowing researchers to generalize results to all non-institutionalized United States (US) civilians. The analysis included 6,432 individuals, which were representative of 94,729,059 US citizens.ResultsPearson’s correlations, chi-square tests, and logistic regression equations were calculated to determine the association between hyperuricemia and MetS. In an unadjusted regression analysis, individuals with hyperuricemia (above 7.0 mg/dL in males and 6.0 mg/dL in females) were 3.19 times more likely to have MetS compared to those with normal uric acid (UA) levels. When controlling for various confounding variables those with hyperuricemia were 1.89 and 1.34 times more likely to have MetS than those with normal UA levels in two additional logistic regression models.ConclusionIn this large cross-sectional study, hyperuricemia was found to be associated with MetS. Additional analyses that controlled for various risk factors previously identified as predictive of MetS still demonstrated hyperuricemia independently associated with MetS. The results of this study suggest a need to understand the metabolic pathways of UA more clearly to further explain the contribution to MetS. Additional research should include prospective clinical trials assessing the effects of UA and the control of UA on MetS and concomitant medical outcomes.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 80%

Uric acid and metabolic syndrome: Findings from national health and nutrition examination survey

Bowden

Adair

Richardson³

2022

Front. Med.

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“…We assessed the relationship between SUA and the cardiometabolic phenotype in the current study, and our ndings show increasing mean values of metabolic syndrome factors, including LDL and cholesterol, in a dose-response manner corresponding to the SUA tertiles. These results are similar to the ndings of the studies carried out previously in various countries [16][17][18]. According to our ndings, the prevalence rates of MHO and MUHL were higher in the second and third tertiles compared to the rst tertile, which had the lowest SUA.…”

Section: Discussionsupporting

confidence: 92%

The Association Between Serum Uric Acid and the Cardiometabolic Phenotype Among Healthcare Workers in Azar Cohort Study

Somi

Frounchi

Ostadrahimi

et al. 2021

Preprint

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Background: As of now, it is unknown whether hyperuricemia can be considered as an independent risk factor or just as a marker to represent the correlation between uric acid and other metabolic syndrome (MetS) risk factors. To the best of the authors’ knowledge, no other work has been reported to study this relationship between serum uric acid (SUA) and cardiometabolic phenotypes. In this work, we intend to study the correlation between SUA and the cardiometabolic phenotype among healthcare workers in Azar cohort study. Method: In this cross-sectional study, anthropometric measurements, serum fasting blood sugar (FBS), triglyceride (TG), cholesterol, high lipoprotein density (HDL), liver enzymes, blood urea nitrogen (BUN), SUA, creatinine (Cr), and blood pressures of 1458 healthcare workers were evaluated. MetS was diagnosed based on ATP III. We classified the participants into four cardiometabolic phenotypes, i.e., metabolically-healthy lean (MHL), metabolically-unhealthy lean (MUHL), metabolically-healthy obese (MHO), and metabolically-unhealthy obese (MUHO).Results: MHL (32.6%) and MHO (66%) have the highest prevalence rate in the first and second SUA tertiles, respectively, which are statistically significant (P-value ≤0.001). We observed an ascending trend in the mean values of WC, TG, cholesterol, low HDL, FBS, BUN, Cr, SBP, DBP, BMI, and liver enzymes from the first SUA tertile to the third SUA tertile (P-value <0.05). Compared to the lowest SUA tertile, the odds of MHO and MUHO increased by 2.29 (95% CI 1.46-3.59) and 5.38 (95%CI 3.45-9.39), respectively. In contrast, no similar trend was observed regarding the association between MUHL and the SUA tertile.Conclusion: We proposed the use of the easily-measured SUA level as a marker for early diagnosis of at-risk MUHL and MHO individuals to administer proper interventions. Further prospective works are needed to identify the effects of SUA on the progression of MetS in various body size subgroups.

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“…One former research found weight, WC, BMI, FBS, TG, TC and LDL levels in high level SUA group were significantly higher than those in low level group. 34 Similarly, in a prospective study, BMI, TG and LDL levels significantly increased in hyperuricemia group. 35 Moreover, our findings indicated that SUA was associated with masses of CFRs.…”

Section: Discussionmentioning

confidence: 88%

Associations of Serum Uric Acid with Clustering of Cardiovascular Risk Factors and a 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Jiangsu Adults, China

Tian¹,

Wang²,

Xie³

et al. 2021

DMSO

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Purpose The relationship between serum uric acid (SUA) and Chinese characteristic 10-year atherosclerotic cardiovascular disease (ASCVD) risk score has not been well evaluated in Chinese populations. Aims of this cross-sectional study were to describe the correlation between SUA level and clustering of prevalent cardiovascular risk factors (CRFs) including overweight, central obesity, hypertension, diabetes and dyslipidemia, as well as the Chinese 10-year ASCVD risk score in adults from Jiangsu Province located in Eastern China. Patients and Methods A total of 7700 adults from 12 cities in Jiangsu Province were selected through multi-stage stratified cluster random sampling method in 2015. Face-to-face interviews, physical examinations and laboratory examinations were carried out to collect the information of the participants. Multivariate logistic analysis was used to analyze the relationship between SUA quartiles and various CVD risk factors. The nonlinear analysis was conducted to evaluate the relationship between SUA levels and the China-PAR 10-year ASCVD risk scores. Results The prevalence of hyperuricemia was 13.3% in all of the participants. By adjusting potential confounders, significant correlations were found between the SUA level and the overweight, central obesity, hypertension and dyslipidemia in both males and females. The clustering of CRFs was different across SUA quantiles ( χ 2 =607.685, P <0.001). After Gamma trend test ( P < 0.001) and ordered logistic regression analysis, it was found out that with the increase of SUA quantiles, prevalent CRFs gradually gathered in both males and females. Furthermore, sex-specific difference was identified between SUA and 10-year ASCVD risk scores. Conclusion The accumulation of CRFs increased with elevated SUA levels, whereas it was different between genders in the relationship between SUA and 10-year ASCVD risk scores. Tailored strategies should be taken when it came to males and females in managing SUA.

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Association of Serum Uric Acid with cardio-metabolic risk factors and metabolic syndrome in seafarers working on tankers

Cited by 10 publications

References 45 publications

Uric acid and metabolic syndrome: Findings from national health and nutrition examination survey

Uric acid and metabolic syndrome: Findings from national health and nutrition examination survey

The Association Between Serum Uric Acid and the Cardiometabolic Phenotype Among Healthcare Workers in Azar Cohort Study

Associations of Serum Uric Acid with Clustering of Cardiovascular Risk Factors and a 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Jiangsu Adults, China

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