Associations of Serum Uric Acid with Clustering of Cardiovascular Risk Factors and a 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Jiangsu Adults, China

Abstract

Purpose The relationship between serum uric acid (SUA) and Chinese characteristic 10-year atherosclerotic cardiovascular disease (ASCVD) risk score has not been well evaluated in Chinese populations. Aims of this cross-sectional study were to describe the correlation between SUA level and clustering of prevalent cardiovascular risk factors (CRFs) including overweight, central obesity, hypertension, diabetes and dyslipidemia, as well as the Chinese 10-year ASCVD risk score in adults from Jiangsu Province located in Eastern China. Patients and Methods A total of 7700 adults from 12 cities in Jiangsu Province were selected through multi-stage stratified cluster random sampling method in 2015. Face-to-face interviews, physical examinations and laboratory examinations were carried out to collect the information of the participants. Multivariate logistic analysis was used to analyze the relationship between SUA quartiles and various CVD risk factors. The nonlinear analysis was conducted to evaluate the relationship between SUA levels and the China-PAR 10-year ASCVD risk scores. Results The prevalence of hyperuricemia was 13.3% in all of the participants. By adjusting potential confounders, significant correlations were found between the SUA level and the overweight, central obesity, hypertension and dyslipidemia in both males and females. The clustering of CRFs was different across SUA quantiles ( χ 2 =607.685, P <0.001). After Gamma trend test ( P < 0.001) and ordered logistic regression analysis, it was found out that with the increase of SUA quantiles, prevalent CRFs gradually gathered in both males and females. Furthermore, sex-specific difference was identified between SUA and 10-year ASCVD risk scores. Conclusion The accumulation of CRFs increased with elevated SUA levels, whereas it was different between genders in the relationship between SUA and 10-year ASCVD risk scores. Tailored strategies should be taken when it came to males and females in managing SUA.

Association Between Serum Uric Acid Levels and Traditional Cardiovascular Risk Factors in Xiamen Residents of China: A Real-World Study

“…In Shanghai population, the prevalence of hyperuricemia was 17.2% (22.2% in men and 10.8% in women) in 2015 ( 18 ). In Jiangsu adults, the prevalence of hyperuricemia was 13.3% (16.9% in men and 10.3% in women) in 2015 ( 19 ). According to our real-world study, the prevalence of hyperuricemia was 32.6% (34.0% in men and 31.6% in women) among Xiamen population ( Table 1 ), which was higher than that in eastern Chinese population in 2015 and in Chinese adults in 2018–2019 ( 17 – 19 ).…”

“…In Jiangsu adults, the prevalence of hyperuricemia was 13.3% (16.9% in men and 10.3% in women) in 2015 ( 19 ). According to our real-world study, the prevalence of hyperuricemia was 32.6% (34.0% in men and 31.6% in women) among Xiamen population ( Table 1 ), which was higher than that in eastern Chinese population in 2015 and in Chinese adults in 2018–2019 ( 17 – 19 ). Changes in lifestyle, eating habits and environmental factors are attributed to the development of hyperuricemia ( 20 ).…”

Associations of serum uric acid with cardiovascular disease risk factors: a retrospective cohort study in southeastern China

“…3 Numerous epidemiological studies have suggested strong associations between serum uric acid (SUA) and CVD risk factors, [4][5][6][7] including hypertension, obesity, diabetes and dyslipidaemia. [8][9][10][11] In animalbased studies, elevated SUA levels have been found to affect cardiovascular and metabolic functions via multiple pathways, such as oxidative stress and endothelial dysfunction, and insulin resistance. 6 12-15 However, ambiguity remains regarding the associations between SUA and CVD risk factors.…”

Association of Hyperuricemia with 10-Year Atherosclerotic Cardiovascular Disease Risk among Chinese Adults and Elders

“…Currently, some studies have used cardiovascular risk scores to explore the relationship between hyperuricemia and CVDs risks in Chinese adults and elders. However, most of these studies are based on population samples from some specific regions or cities, and there are few representative samples covering various regions and ethnic groups in China [ 26 , 27 , 28 , 29 ]. Secondly, most of the cardiovascular risk scores used in these studies are on the basis of foreign population cohorts, while lacking studies to verify the applicability of these risk scores to Chinese populations [ 30 , 31 ].…”