Association of the −112A &gt; C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes

Fukuyama, Keiko; Ohara, Takeshi; Hirota, Yushi; Maeda, Kengo; Kuno, Shin-ichi; Zenibayashi, Masako; Teranishi, Tetsuya; Kouyama, Kunichi; Maeda, Eiichi; Sakamoto, Norihiro; Kasuga, Masato

doi:10.1016/j.bbrc.2005.11.140

Cited by 20 publications

(17 citation statements)

References 29 publications

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“…In the present data, FPG was transiently increased at day 3 after GC treatment initiation, and then it returned to the normal range after day 7. Serum IRI level was increased at day 3, and then somewhat returned to the lower level, but was still significantly higher at day 7 d o n d a y s 3 , 7 , 1 4 , 2 8 a n d a t (26). In addition, GC may stimulate liver production of nascent HDL (27) …”

Section: Several Reports Have Indicated That Fpg and Iri Levels Were mentioning

confidence: 96%

Prospective Short-Term Effects of Glucocorticoid Treatment on Glucose and Lipid Metabolism in Japanese

Kuroki¹,

Kaji

Kanda

et al. 2010

Intern. Med.

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Section: Several Reports Have Indicated That Fpg and Iri Levels Were mentioning

confidence: 96%

Prospective Short-Term Effects of Glucocorticoid Treatment on Glucose and Lipid Metabolism in Japanese

Kuroki¹,

Kaji

Kanda

et al. 2010

Intern. Med.

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“…Further, this SNP was previously indicated as contributing to hepatic lipid accumulation and altering insulin sensitivity in Japanese individuals with Type II diabetes mellitus (NIDDM) [18]. In our population, the lack of association of this SNP with any obesity-related phenotype could be due to the younger mean age of our patients respect to those investigated by Fukuyama et al [21] (32.1 years versus 56.6 years, resp.) and to different ethnic background of the studied groups.…”

Section: Resultsmentioning

confidence: 62%

Sequence Analysis of theUCP1Gene in a Severe Obese Population from Southern Italy

et al. 2011

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Brown adipose tissue, where Uncoupling Protein 1 (UCP1) activity uncouples mitochondrial respiration, is an important site of facultative energy expenditure. This tissue may normally function to prevent obesity. Our aim was to investigate by sequence analysis the presence of UCP1 gene variations that may be associated with obesity. We studied 100 severe obese adults (BMI > 40 kg/m2) and 100 normal-weight control subjects (BMI range = 19–24.9 kg/m2). We identified 7 variations in the promoter region, 4 in the intronic region and 4 in the exonic region. Globally, 72% of obese patients bore UCP1 polymorphisms. Among UCP1 variants, g.IVS4−208T>G SNP was associated with obesity (OR: 1.77; 95% CI = 1.26–2.50; P = .001). Further, obese patients bearing the g.−451C>T (CT+TT) or the g.940G>A (GA+AA) genotypes showed a higher BMI than not polymorphic obese patients (P = .008 and P = .043, resp.). In conclusion, UCP1 SNPs could represent “thrifty” factors that promote energy storage in prone subjects.

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“…Additionally, the adipocyte-derived MCP-1 plays a crucial role in initiating atherosclerosis by recruiting monocytes to the arterial wall [40][41][42][43]. However, divergent findings were reported in individuals with altered traditional cardiovascular risk factors, such as elevated plasma glucose [39].…”

Section: Discussionmentioning

confidence: 96%

Novel biomarkers of cardiometabolic risk are associated with plasma glucose within non-diabetic range. The Brazilian Longitudinal Study of Adult Health – ELSA-Brasil

Almeida-Pititto¹,

Ribeiro-Filho²,

Lotufo³

et al. 2015

Diabetes Research and Clinical Practice

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Association of the −112A > C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes

Cited by 20 publications

References 29 publications

Prospective Short-Term Effects of Glucocorticoid Treatment on Glucose and Lipid Metabolism in Japanese

Prospective Short-Term Effects of Glucocorticoid Treatment on Glucose and Lipid Metabolism in Japanese

Sequence Analysis of theUCP1Gene in a Severe Obese Population from Southern Italy

Novel biomarkers of cardiometabolic risk are associated with plasma glucose within non-diabetic range. The Brazilian Longitudinal Study of Adult Health – ELSA-Brasil

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