Association of the carriage of IL-1B rs1143634 and rs16944 polymorphisms and BDNF rs6265 polymorphism with temporal lobe epilepsy

Panina, Yu. S.; Дмитренко, Д. В.; Шнайдер, Н. А.; Егорова, Э.В.; Usoltseva, A. А.

doi:10.14412/2074-2711-2019-2-46-51

Cited by 2 publications

(2 citation statements)

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“…in a genetic association study of 194 adult patients [40]. IL-1beta rs1143634 was significantly associated with risk of temporal lobe epilepsy in a study of 287 adult patients (OR 2.0, CI 1.3-3.1) [41].…”

Section: Discussionmentioning

confidence: 98%

“…For example, ADK rs11001109 was found to be significantly associated with pharmacoresistant epilepsy (OR 1.7, CI 1.1–2.7) in a genetic association study of 194 adult patients [40]. IL‐1beta rs1143634 was significantly associated with risk of temporal lobe epilepsy in a study of 287 adult patients (OR 2.0, CI 1.3–3.1) [41]. The presence of C677T polymorphism of the MTHFR gene was associated with an increased risk of epilepsy [42, 43].…”

Section: Discussionmentioning

confidence: 99%

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Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review

Misra

Quinn

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et al. 2023

Euro J of Neurology

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Background and purpose:The genetics of late seizure or epilepsy secondary to traumatic brain injury (TBI) or stroke are poorly understood. We undertook a systematic review to test the association of single-nucleotide polymorphisms (SNPs) with the risk of posttraumatic epilepsy (PTE) and post-stroke epilepsy (PSE). Methods:We followed methods from our prespecified protocol on PROSPERO to identify indexed articles for this systematic review. We collated the association statistics from the included articles to assess the association of SNPs with the risk of epilepsy amongst TBI or stroke patients. We assessed study quality using the Q-Genie tool. We report odds ratios (OR) and hazard ratios with 95% confidence intervals (CIs). Results:The literature search yielded 420 articles. We included 16 studies in our systematic review, of which seven were of poor quality. We examined published data on 127 SNPs from 32 genes identified in PTE and PSE patients. Eleven SNPs were associated with a significantly increased risk of PTE. Three SNPs, TRMP6 rs2274924, ALDH2 rs671, and CD40 -1C/T, were significantly associated with an increased risk of PSE, while two, AT1R rs12721273 and rs55707609, were significantly associated with reduced risk. The meta-analysis for the association of the APOE ɛ4 with PTE was nonsignificant (OR 1.8, CI 0.6-5.6). Conclusions:The current evidence on the association of genetic polymorphisms in epilepsy secondary to TBI or stroke is of low quality and lacks validation. A collaborative effort to pool genetic data linked to epileptogenesis in stroke and TBI patients is warranted.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review

Misra

Quinn

Falcone

et al. 2023

Euro J of Neurology

View full text Add to dashboard Cite

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Limbic Encephalitis Associated with COVID-19

et al. 2021

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Limbic encephalitis (LE) is an inflammatory disease of the brain, in which lesion is anatomically limited in structures of the limbic system. In some cases, LE can start with symptoms of limbic dysfunction with further involvement of other regions of the brain. Classic LE syndrome includes such symptoms as the development of personality disorders, depression, sleep disorders, epileptic seizures, hallucinations and cognitive disorders (short-term and long-term memory impairment). The information of clinical examination, electroencephalogram (EEG), magnetic resonance imaging (MRI) and cerebrospinal fluid studies (CSF) suggest the diagnosis of LE in most patients with Coronavirus Disease 2019 (COVID-19).

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Association of the carriage of IL-1B rs1143634 and rs16944 polymorphisms and BDNF rs6265 polymorphism with temporal lobe epilepsy

Cited by 2 publications

References 27 publications

Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review

Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review

Limbic Encephalitis Associated with COVID-19

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